Niranjan Nagarajan
@niranjantw.bsky.social
Computational Biologist and Microbiome Scientist at the National University of Singapore
Pinned
Citywide metagenomic surveillance of food centres reveals local microbial signatures and antibiotic resistance gene enrichment - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Citywide metagenomic surveillance of food centres reveals local microbial signatures and antibiotic resistance gene enrichment
nature.com
Published finally! Our study describing the use of metagenomics for AMR/pathogen surveillance in food-centres island-wide in Singapore is out in npj Antimicrobial & Resistance:
nature.com/articles/s44...
nature.com/articles/s44...
Reposted by Niranjan Nagarajan
Our new paper on high-throughput isolation of Bifidobacterium just got published! A very nice adventure starting with the supervision of @lamhaiha.bsky.social, a talented intern, and a nice collab with our BSight expert @isaacyueyuan.bsky.social! Stay tuned for more isolation and Bifido work! :)
Thrilled to share our high-throughput Bifidobacterium isolation work in Microbiology Spectrum! journals.asm.org/doi/10.1128/...
By integrating a single-cell dispenser into a culturomics workflow, we accelerated the isolation of individual bacterial cells, allowing robust strain-level resolution.
By integrating a single-cell dispenser into a culturomics workflow, we accelerated the isolation of individual bacterial cells, allowing robust strain-level resolution.
High-throughput single-cell isolation of Bifidobacterium strains from the human gut microbiome | Microbiology Spectrum
The field of high-throughput microbial culturomics is still in its early stages. Enhancing
our ability to isolate and phenotypically test bacterial strains from complex communities
is crucial for adva...
journals.asm.org
January 1, 2026 at 9:20 AM
Our new paper on high-throughput isolation of Bifidobacterium just got published! A very nice adventure starting with the supervision of @lamhaiha.bsky.social, a talented intern, and a nice collab with our BSight expert @isaacyueyuan.bsky.social! Stay tuned for more isolation and Bifido work! :)
Reposted by Niranjan Nagarajan
Excited to share my first-ever publication on high-throughput Bifidobacterium isolation! Special thanks to my co-author,
@isaacyueyuan.bsky.social, for this wonderful write-up. I would also want to thank @niranjantw.bsky.social and @jsgounot.bsky.social for their uwavering support and guidance.
@isaacyueyuan.bsky.social, for this wonderful write-up. I would also want to thank @niranjantw.bsky.social and @jsgounot.bsky.social for their uwavering support and guidance.
Thrilled to share our high-throughput Bifidobacterium isolation work in Microbiology Spectrum! journals.asm.org/doi/10.1128/...
By integrating a single-cell dispenser into a culturomics workflow, we accelerated the isolation of individual bacterial cells, allowing robust strain-level resolution.
By integrating a single-cell dispenser into a culturomics workflow, we accelerated the isolation of individual bacterial cells, allowing robust strain-level resolution.
High-throughput single-cell isolation of Bifidobacterium strains from the human gut microbiome | Microbiology Spectrum
The field of high-throughput microbial culturomics is still in its early stages. Enhancing
our ability to isolate and phenotypically test bacterial strains from complex communities
is crucial for adva...
journals.asm.org
January 3, 2026 at 4:15 AM
Excited to share my first-ever publication on high-throughput Bifidobacterium isolation! Special thanks to my co-author,
@isaacyueyuan.bsky.social, for this wonderful write-up. I would also want to thank @niranjantw.bsky.social and @jsgounot.bsky.social for their uwavering support and guidance.
@isaacyueyuan.bsky.social, for this wonderful write-up. I would also want to thank @niranjantw.bsky.social and @jsgounot.bsky.social for their uwavering support and guidance.
High-throughput isolation of probiotic species from the gut microbiome!
Great to have this work out early in the year:
journals.asm.org/eprint/KHNHX...
We report our experience with the B.SIGHT system from @cytena.bsky.social
Great to have this work out early in the year:
journals.asm.org/eprint/KHNHX...
We report our experience with the B.SIGHT system from @cytena.bsky.social
January 1, 2026 at 7:21 AM
High-throughput isolation of probiotic species from the gut microbiome!
Great to have this work out early in the year:
journals.asm.org/eprint/KHNHX...
We report our experience with the B.SIGHT system from @cytena.bsky.social
Great to have this work out early in the year:
journals.asm.org/eprint/KHNHX...
We report our experience with the B.SIGHT system from @cytena.bsky.social
Published finally! Our study describing the use of metagenomics for AMR/pathogen surveillance in food-centres island-wide in Singapore is out in npj Antimicrobial & Resistance:
nature.com/articles/s44...
nature.com/articles/s44...
Citywide metagenomic surveillance of food centres reveals local microbial signatures and antibiotic resistance gene enrichment - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Citywide metagenomic surveillance of food centres reveals local microbial signatures and antibiotic resistance gene enrichment
nature.com
September 6, 2025 at 2:31 AM
Published finally! Our study describing the use of metagenomics for AMR/pathogen surveillance in food-centres island-wide in Singapore is out in npj Antimicrobial & Resistance:
nature.com/articles/s44...
nature.com/articles/s44...
Skin #metatranscriptomics could be transformational in a way not seen in gut/oral studies as
1) Defined spatial sampling can provide in vivo relevant insights
2) Microbial mRNA is dominant, but human mRNA is also readily detected and quantified
www.nature.com/articles/s41...
1) Defined spatial sampling can provide in vivo relevant insights
2) Microbial mRNA is dominant, but human mRNA is also readily detected and quantified
www.nature.com/articles/s41...
Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - Nature Biotechnology
Skin metagenomic and metatranscriptomic analysis shows divergence between microbial abundance and activity.
www.nature.com
September 1, 2025 at 11:36 AM
Skin #metatranscriptomics could be transformational in a way not seen in gut/oral studies as
1) Defined spatial sampling can provide in vivo relevant insights
2) Microbial mRNA is dominant, but human mRNA is also readily detected and quantified
www.nature.com/articles/s41...
1) Defined spatial sampling can provide in vivo relevant insights
2) Microbial mRNA is dominant, but human mRNA is also readily detected and quantified
www.nature.com/articles/s41...
Our study developing a skin metatranscriptomics protocol is now out in @natbiotech.nature.com!
We finally have the ability to study microbial activity on skin and identify key functional genes playing a role in diseases.
Amazing team of Chia Minghao and Amanda Ng 👏
nature.com/articles/s41...
We finally have the ability to study microbial activity on skin and identify key functional genes playing a role in diseases.
Amazing team of Chia Minghao and Amanda Ng 👏
nature.com/articles/s41...
August 30, 2025 at 2:17 AM
Our study developing a skin metatranscriptomics protocol is now out in @natbiotech.nature.com!
We finally have the ability to study microbial activity on skin and identify key functional genes playing a role in diseases.
Amazing team of Chia Minghao and Amanda Ng 👏
nature.com/articles/s41...
We finally have the ability to study microbial activity on skin and identify key functional genes playing a role in diseases.
Amazing team of Chia Minghao and Amanda Ng 👏
nature.com/articles/s41...
Reposted by Niranjan Nagarajan
Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - @niranjantw.bsky.social @astar-gis.bsky.social go.nature.com/4fVg95j
Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - Nature Biotechnology
Skin metagenomic and metatranscriptomic analysis shows divergence between microbial abundance and activity.
go.nature.com
August 28, 2025 at 3:50 PM
Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - @niranjantw.bsky.social @astar-gis.bsky.social go.nature.com/4fVg95j
Our work on direct @nanoporetech.com sequencing of non-canonical bases in now out in @natcomms.nature.com!
Read all about it here: nature.com/articles/s41...
Great collab with Chew and Hirao lab
x.com/NiranjanTW/s...
Read all about it here: nature.com/articles/s41...
Great collab with Chew and Hirao lab
x.com/NiranjanTW/s...
Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning - Nature Communications
Perez, Kimoto, Rajakumar and colleagues present a fast and accurate DNA sequencing method that reads canonical and non-canonical bases using AI and nanopore technology. The approach enables an expande...
nature.com
August 22, 2025 at 9:32 AM
Our work on direct @nanoporetech.com sequencing of non-canonical bases in now out in @natcomms.nature.com!
Read all about it here: nature.com/articles/s41...
Great collab with Chew and Hirao lab
x.com/NiranjanTW/s...
Read all about it here: nature.com/articles/s41...
Great collab with Chew and Hirao lab
x.com/NiranjanTW/s...
Reposted by Niranjan Nagarajan
Find out how our researchers—Associate Director @niranjantw.bsky.social, GIS Innovation Fellow Chayaporn Suphavilai and Dr Karrie Ko—discovered a new variation of 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 𝘢𝘶𝘳𝘪𝘴 (𝘊.𝘢𝘶𝘳𝘪𝘴)—𝗰𝗹𝗮𝗱𝗲 𝗩𝗜—a drug-resistant yeast that kept infectious disease experts on high alert worldwide.
Full story below👇:
Full story below👇:
research.a-star.edu.sg
May 27, 2025 at 9:01 AM
Find out how our researchers—Associate Director @niranjantw.bsky.social, GIS Innovation Fellow Chayaporn Suphavilai and Dr Karrie Ko—discovered a new variation of 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 𝘢𝘶𝘳𝘪𝘴 (𝘊.𝘢𝘶𝘳𝘪𝘴)—𝗰𝗹𝗮𝗱𝗲 𝗩𝗜—a drug-resistant yeast that kept infectious disease experts on high alert worldwide.
Full story below👇:
Full story below👇:
Reposted by Niranjan Nagarajan
Studying low-biomass environments in microbiome research? The struggle is real when it comes to contamination! Even the tiniest sprinkle of external microbes can throw off your results, making traditional methods a no-go. Details in link below:
@niranjantw.bsky.social www.nature.com/articles/s41...
@niranjantw.bsky.social www.nature.com/articles/s41...
Guidelines for preventing and reporting contamination in low-biomass microbiome studies - Nature Microbiology
In this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize contaminants.
www.nature.com
June 24, 2025 at 4:07 AM
Studying low-biomass environments in microbiome research? The struggle is real when it comes to contamination! Even the tiniest sprinkle of external microbes can throw off your results, making traditional methods a no-go. Details in link below:
@niranjantw.bsky.social www.nature.com/articles/s41...
@niranjantw.bsky.social www.nature.com/articles/s41...
Reposted by Niranjan Nagarajan
Which skin microbiome type do you have 🤔 Check out our exciting work from the Asian Skin Microbiome Program offering new insights of skin microbiome population heterogeneity👇 #skinmicrobiome #microbiomescience
Super thrilled to share our labor of love from the Asian Skin Microbiome Program! We collected >3,500 skin samples, built metagenomic libraries w/ >70 billion reads and >10TB of data to study heterogeneity of the skin microbiome in the general population (200 adults, 18 sites) t.co/ZylbJMpvpw
Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites
The human skin microbiome is increasingly recognized to influence skin health, immune function and disease susceptibility. However, large-scale, multi-site metagenomic studies in the general populatio...
www.biorxiv.org
April 28, 2025 at 9:36 AM
Which skin microbiome type do you have 🤔 Check out our exciting work from the Asian Skin Microbiome Program offering new insights of skin microbiome population heterogeneity👇 #skinmicrobiome #microbiomescience
Super thrilled to share our labor of love from the Asian Skin Microbiome Program! We collected >3,500 skin samples, built metagenomic libraries w/ >70 billion reads and >10TB of data to study heterogeneity of the skin microbiome in the general population (200 adults, 18 sites) t.co/ZylbJMpvpw
Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites
The human skin microbiome is increasingly recognized to influence skin health, immune function and disease susceptibility. However, large-scale, multi-site metagenomic studies in the general populatio...
www.biorxiv.org
April 28, 2025 at 4:52 AM
Super thrilled to share our labor of love from the Asian Skin Microbiome Program! We collected >3,500 skin samples, built metagenomic libraries w/ >70 billion reads and >10TB of data to study heterogeneity of the skin microbiome in the general population (200 adults, 18 sites) t.co/ZylbJMpvpw
A bit late to joining the Bluesky party, but it's great to see all the amazing scientists who are on this platform! Looking forward to connecting with all of you here (on twitter as @niranjantw ... so keeping the handle consistent).
April 28, 2025 at 1:13 AM
A bit late to joining the Bluesky party, but it's great to see all the amazing scientists who are on this platform! Looking forward to connecting with all of you here (on twitter as @niranjantw ... so keeping the handle consistent).