Thomas Norman
@normanlab.bsky.social
Associate Member in csBio at Memorial Sloan Kettering. Perturb-seq, single-cell functional genomics, and techniques for perturbing the genome.
Pinned
New preprint on technologies to scale up CRISPR screens.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
My lab at MSKCC in New York is hiring for two positions. Join us at the frontier of functional genomics, studying fibroblast state transitions, combinatorial genetics, and ECM in disease. Please share with anyone who might be a good fit! (Mustache not required.)
February 4, 2026 at 3:22 PM
My lab at MSKCC in New York is hiring for two positions. Join us at the frontier of functional genomics, studying fibroblast state transitions, combinatorial genetics, and ECM in disease. Please share with anyone who might be a good fit! (Mustache not required.)
New preprint on technologies to scale up CRISPR screens.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
January 20, 2026 at 1:42 PM
New preprint on technologies to scale up CRISPR screens.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.
We also introduce an approach for cloning lentiviral libraries with billions of elements.
Reposted by Thomas Norman
💫PUBLISHED @natgenet.nature.com
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states - Nature Genetics
CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.
www.nature.com
August 27, 2025 at 1:26 PM
💫PUBLISHED @natgenet.nature.com
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
Reposted by Thomas Norman
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
August 27, 2025 at 3:09 PM
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.