Thomas Norman
@normanlab.bsky.social
Assistant Member in csBio at Memorial Sloan Kettering. Perturb-seq, single-cell functional genomics, and techniques for perturbing the genome.
Pinned
Thomas Norman
@normanlab.bsky.social
· Aug 6
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Reposted by Thomas Norman
💫PUBLISHED @natgenet.nature.com
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states - Nature Genetics
CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.
www.nature.com
August 27, 2025 at 1:26 PM
💫PUBLISHED @natgenet.nature.com
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.
By Kaden M. Southard, @normanlab.bsky.social and colleagues!
⬇️
www.nature.com/articles/s41...
Reposted by Thomas Norman
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
August 27, 2025 at 3:09 PM
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.