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OHSU-MMI @ohsummi.bsky.social · 25d

Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.

A group foto of the MMI department at the 2025 retreat

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Reposted by OHSU-MMI

Bella Rauch @rauchlab.bsky.social · Sep 8

Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!

🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...

#blackinImmuno #BlackinMicro #Sacnas

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Stand Up for Science! @standupforscience.bsky.social · Jul 18

The Trump admin is erasing critical federal data - including climate trends, water quality, wildfire risk, public health stats, and pollution monitoring.

When the data goes dark, the American lives are at risk.

This is how To Sabatoge A Nation👇

zurl.co/slECM

Trump’s Cuts Are Making Federal Data Disappear

Online tools that professionals use for everything from diagnosing diseases to calculating insurance payouts are going dark.

zurl.co

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OHSU-MMI @ohsummi.bsky.social · Jul 15

Congratulations to Bahareh Ajami and her lab @baharehajami.bsky.social ! Dr. Ajami and her team of 6 are studying one of the most promising theories in ALS immunology today. alsnorthwest.org/research-app...

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OHSU-MMI @ohsummi.bsky.social · Jul 2

Congratulations to @tafesselab.bsky.social for promotion to Full Professor with tenure!!! Well deserved!

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OHSU-MMI @ohsummi.bsky.social · Jun 30

Check out the mucosal Immunology podcast episode with MMI faculty member @rauchlab.bsky.social

Mucosal Immunology @mucosalimmunol.bsky.social · Jun 30

It’s #MucosalMonday and the June episode of the Mucosal Immunology Podcast is out with @rauchlab.bsky.social @marionbrunck.bsky.social, @ashu-mangalam.bsky.social, @kknoop.bsky.social and more! Subscribe and follow on your favorite podcast platform. open.spotify.com/episode/5H1k...

Inflammasomes and Tuft Cells

Mucosal Immunology Podcast · Episode

open.spotify.com

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Reposted by OHSU-MMI

tafesselab.bsky.social @tafesselab.bsky.social · Jun 10

It’s finally out!

Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊

Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social

pubmed.ncbi.nlm.nih.gov/40473211/

Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed

Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...

pubmed.ncbi.nlm.nih.gov

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Reposted by OHSU-MMI

tafesselab.bsky.social @tafesselab.bsky.social · Jun 4

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

www.biorxiv.org

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OHSU-MMI @ohsummi.bsky.social · May 23

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Kristin Michel @kmichel.bsky.social · May 22

Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...

In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature

An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...

www.nature.com

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OHSU-MMI @ohsummi.bsky.social · May 19

Congratulations to the Tafesse lab on their recent publication on the effects on timing in repeat vaccinations!

tafesselab.bsky.social @tafesselab.bsky.social · May 19

Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!

@ohsunews.bsky.social @ohsummi.bsky.social

www.nature.com/articles/s43...

Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine

Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...

www.nature.com

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OHSU-MMI @ohsummi.bsky.social · Apr 30

Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...

Analysis of Factors That Regulate HIV-1 Fusion in Reverse

Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...

pmc.ncbi.nlm.nih.gov

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Reposted by OHSU-MMI

Leigh Knodler @leighknodler.bsky.social · Apr 4

Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...

kermit the frog from the muppet show is standing in front of a red curtain .

ALT: kermit the frog from the muppet show is standing in front of a red curtain .

media.tenor.com

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Reposted by OHSU-MMI

Patrick S. Mitchell @psmitchej.bsky.social · Mar 28

Federal funding of biomedical research has been a remarkably successful partnership, with benefits that are so intertwined in our daily lives that they can be easy to take for granted.

So what will we lose if the U.S. continues to defund research?

theconversation.com/cuts-to-scie...

Cuts to science research funding cut American lives short − federal support is essential for medical breakthroughs

The National Institutes of Health has been integral to scientific progress in treating countless human diseases. Without its support, patients will ultimately pay the price.

theconversation.com

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OHSU-MMI @ohsummi.bsky.social · Mar 25

Thank you to Adair Borges @adairb.bsky.social for giving a great talk about her exciting science at @arcadiascience.com and for discussing careers in biotech with our trainees!

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OHSU-MMI @ohsummi.bsky.social · Mar 20

New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs:
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".

www.embopress.org/doi/full/10....

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal

imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

www.embopress.org

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OHSU-MMI @ohsummi.bsky.social · Mar 14

New publication out of the @rauchlab.bsky.social at OHSU MMI

Journal of Experimental Medicine @jem.org · Mar 13

First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/...

#InfectiousDisease

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Reposted by OHSU-MMI

Bella Rauch @rauchlab.bsky.social · Mar 4

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...

It was signed by over 450 OHSU researchers!

It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal

"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."

www.bizjournals.com

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Reposted by OHSU-MMI

Bella Rauch @rauchlab.bsky.social · Feb 28

Come join us! No excuses!!!

Brittany Barker @brittanysbarker.bsky.social · Feb 28

Only 1 week until the Stand Up For Science rally at the OR capitol! We'll be hearing from Rep. Andrea Salinas and at least 4 renowned scientists. Rally with me to defend science from censorship and cuts! Let's make this big! #sciencenotsilence #standupforscience2025 @standupforscience.bsky.social

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Reposted by OHSU-MMI

Lauren B. Rodda @laurenrodda.bsky.social · Feb 22

NIH funding freeze stalls $1.5 billion in medical research grant funding : Shots - Health News www.npr.org/sections/sho...

NIH funding freeze stalls applications on $1.5 billion in medical research funds

The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.

www.npr.org

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Reposted by OHSU-MMI

Bella Rauch @rauchlab.bsky.social · Feb 21

Join me in standing up for science on March 7. in Salem, Oregon!
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org

A flyer for the “stand up for science” event March 7, 2025, at the Oregon capitol (Salem)

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OHSU-MMI @ohsummi.bsky.social · Feb 12

Congratulations Ankit!!

Bella Rauch @rauchlab.bsky.social · Feb 12

Huge gratulations to Ankit @nkeet50.bsky.social , postdoc in the lab, for receiving the IRACDA fellowship, a fantastic mechanism that rewards scientific excellence and teaching potential.
My trainees are crushing it, 3/4 of them are self-funded! I wish that would rub off on my grant applications...😬

A portrait of Ankit Pandeya, IRACDA fellow

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OHSU-MMI @ohsummi.bsky.social · Feb 6

@laurenrodda.bsky.social and her trainee @georgecelis.bsky.social from our department, together with @joshuamoreau.bsky.social , Rashi Yadav and Abrar Samiea from @ohsuknight.bsky.social wrote a review on B-cells, check it out!

Nature Reviews Immunology @natrevimmunol.nature.com · Feb 6

NEW Review: B cells in non-lymphoid tissues
by Abrar Samiea @georgecelis.bsky.social Rashi Yadav @laurenrodda.bsky.social @joshuamoreau.bsky.social
Highlighting new insights into mechanisms of tissue B cell function and immunotherapeutic targets
#immunology #immunosky

B cells in non-lymphoid tissues - Nature Reviews Immunology

B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mechanisms of tissue B cell function as well as efforts to le...

www.nature.com

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Reposted by OHSU-MMI

Edelblum Lab @edelblumlab.bsky.social · Jan 6

If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky

WINGS | edelblumlab

Women Innovating in Gastrointestinal Science is a group of basic & translational GI researchers that provides a community to connect, empower and inspire female faculty.

www.edelblumlab.com

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OHSU-MMI @ohsummi.bsky.social · Dec 10

A big thank you to Kelsey Sivick, our invited seminar speaker from Arcus biosciences, for giving a riveting talk about the development of a TIGIT inhibitor and educating our trainees on careers in biotech!

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OHSU-MMI @ohsummi.bsky.social · Nov 25

Congratulations to the newly minted Dr. Huber, who successfully defended their thesis on MR1 regulation, done in the Harriff lab, last Friday!!

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