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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · 4d

Enjoyed a dive into membrane tension sensing in a firing synapse presented by @agatawitkowska.bsky.social at #GSM2025 @cim-imprs-gsm.bsky.social

Enjoyed the dive into mechanisms of membrane tension sensing in

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Zunlong Ke @zunlongke.bsky.social · 4d

Really cool story on a FRET biosensor by Bijun Tang @bijuntang.bsky.social and an amazing team, now published @science.org
I’m so proud of your PhD work at @slcuplants.bsky.social
Below is the lockdown time in 2020 when you spent long hours screening your FRET biosensor, now known as SalicS1!

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · 5d

Testing photobooth with @agatawitkowska.bsky.social at #GSM2025 @cim-imprs-gsm.bsky.social Thanks to the organisers and speakers for a fantastic meeting!

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Ben Engel @cellarchlab.com · 5d

What happens when the cell's powerhouse gets stressed out? 💪🥵 Great visualization in this #Mitochondria #TeamTomo study! Congrats @denkenny.bsky.social @ruferbus.bsky.social & crew 🧪 🧶🧬 🔬

Kenneth Ehses @denkenny.bsky.social · 6d

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Briggs Group @briggsgroup.bsky.social · 8d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Sep 8

Great opportunity!

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Dear scientific community,

I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.

my.corehr.com/pls/uoxrecru...

my.corehr.com/pls/uoxrecru...

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Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Sep 4

Fascinating! Congratulations!

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Brett Collins @brettcollins.bsky.social · Sep 3

🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social‬, ‪@rosemaryjcater.bsky.social‬. @kmichie.bsky.social‬. 1/n

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking

The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...

www.biorxiv.org

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Lorenz Lab @sonjalorenzlab.bsky.social · Sep 2

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Sep 2

Close to magic membrane perturbation experiments to understand the ER to Golgi export.

Noemi Jiménez-Rojo @noemijimenezrojo.bsky.social · Sep 2

Finally out! With our "PhotoCells" we can dynamically control membrane viscosity in living cells revealing how physical properties of membranes fine-tune cellular logistics.
Truly interdisciplinary and collaborative research, made possible thanks to all our fantastic collaborators. Congrats to all!

Johannes Morstein @morstein.bsky.social · Aug 14

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social

pubs.acs.org/doi/10.1021/...

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Alister Burt @alisterburt.bsky.social · Aug 30

Building things with extensibility in mind is a true catalyst for innovation - beautifully demonstrated, I'm excited to see where 2DTM for in situ structural biology goes from here! congratulations to Matthew, @joshdcryoem.bsky.social, Laina and @bronwynalucas.bsky.social on this amazing work 🥳

Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 25

Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof

CHIP protects lysosomes from CLN4 mutant-induced membrane damage

Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...

rdcu.be

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 21

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 21

Textbook worth study of intracellular lipid transport.

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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Johannes Morstein @morstein.bsky.social · Aug 14

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social

pubs.acs.org/doi/10.1021/...

Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking

The lipid composition of cellular membranes is highly dynamic and undergoes continuous remodeling, affecting the biophysical properties critical to biological function. Here, we introduce an optical a...

pubs.acs.org

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 7

It's a true superpower when things just work. Get a proper feel for it when setting up my group IT resources 😂

oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 7

Congrats Emily. Well deserved!

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Misha Kudryashev @mishakudryashev.bsky.social · Aug 4

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇

For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!

www.mdc-berlin.de/postdocs#t-g...

www.mdc-berlin.de

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Liz Miller @lizmillercu.bsky.social · Aug 4

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...

Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites

Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

www.biorxiv.org

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André Nadler @nadlerlab.bsky.social · Jan 31

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

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Brett Collins @brettcollins.bsky.social · Jul 31

www.biorxiv.org/content/10.1...

Hybrid endosomal coats containing different classes of sorting nexins

Endosomes are protein sorting stations where multiple coats form tubulovesicular carriers exporting proteins to the Golgi, the plasma membrane, or endo-lysosomal compartments. Distinct classes of sort...

www.biorxiv.org

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Briggs Group @briggsgroup.bsky.social · Apr 4

Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.

www.nature.com/articles/s41...

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