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Reposted by Chlanda lab

Jakob Meier-Credo @meiercredo.bsky.social · 25d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Reposted by Chlanda lab

Guenter Resch @nexperion.net · 21d

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026

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Reposted by Chlanda lab

Lars-Anders Carlson @lacarlson.bsky.social · 22d

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...

Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM

Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…

www.sciencedirect.com

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Reposted by Chlanda lab

Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

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oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 21

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

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Reposted by Chlanda lab

François Mayer @francoismayer.bsky.social · Jun 13

Awesome malaria study out now in Nature Microbiology:

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!

@freddyfrischknecht.bsky.social

www.nature.com/articles/s41...

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology

A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.

www.nature.com

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Reposted by Chlanda lab

Emily Bruce @brucelab.bsky.social · Jun 10

Really enjoyed writing about one of my favorite topics (influenza filaments). There is so much exciting new filament research now, it is clearly no longer 'the graveyard of postdocs' Bob Lamb called the topic during my PhD. www.embopress.org/doi/full/10....

Influenza filaments: a graveyard of postdocs no longer? | The EMBO Journal

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Chlanda lab @chlandalab.bsky.social · Jun 11

Very nice News&Views summary written by
‪@brucelab.bsky.social‬ about our work and work by Ed Partlow et al. (NIH) that influenza A virus filamentous morphology plays an important role in infection (www.nature.com/articles/s41...) can.
‪Thank you!
(www.embopress.org/doi/full/10....)

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Chlanda lab @chlandalab.bsky.social · Jun 11

We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!

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Chlanda lab @chlandalab.bsky.social · Jun 5

Very well deserved, congratulations, Tanmay!

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Reposted by Chlanda lab

Yi-Wei Chang @yiweichang.bsky.social · May 15

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

www.science.org

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Reposted by Chlanda lab

Harry Low’s Lab @lowlab.bsky.social · Apr 28

Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

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Florent Waltz @florentwaltz.bsky.social · Apr 25

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

Lorenz Lamm @lorenzlamm.bsky.social · Apr 25

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

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Reposted by Chlanda lab

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 23

A colder frontier in cryo-EM 🧪🔬

Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).

Read more: tinyurl.com/mwwcunkc

#LMBResearch

The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.

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Jan Philipp Kreysing @jpkreysing.bsky.social · Apr 11

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

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Sven Klumpe @svenklumpe.bsky.social · Apr 9

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

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Daniel Hurdiss @danielhurdiss.bsky.social · Mar 26

I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊

"A coronavirus assembly inhibitor that targets the viral membrane protein"

www.nature.com/articles/s41...

A huge congrats to everyone involved! 🎉

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Chlanda lab @chlandalab.bsky.social · Mar 22

Congratulations Florent, Ben, and the team! Beautiful work!

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bioRxivpreprint @biorxivpreprint.bsky.social · Mar 15

Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1

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Chlanda lab @chlandalab.bsky.social · Mar 5

Congratulations, Dominik and Briggs lab! Amazing work!

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Chlanda lab @chlandalab.bsky.social · Mar 5

This is a great opportunity to establish a virology research group at CIID, Heidelberg University!

Center for Integrative Infectious Diseases Research (CIID) @ciid-heidelberg.bsky.social · Mar 5

Applications are open for new Schaller Research Group Leader Positions in the field of Infectious Diseases at Heidelberg University. These generously funded positions of 5+2 years are a great opportunity for young virologists!

Find out more here:

www.klinikum.uni-heidelberg.de/fileadmin/in...

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Reposted by Chlanda lab

Heidelberg University Biochemistry Center @bzh-hd.bsky.social · Mar 2

🚨 We are hiring 🚨

We seek to fill a full-time teaching position starting September 1, 2025!

We look forward to your application (cover letter, CV, certificates, etc.) in a single PDF.

Deadline: March 14, 2025

@uniheidelberg.bsky.social
@bzh-hd.bsky.social

👇👇👇👇👇👇👇

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Chlanda lab @chlandalab.bsky.social · Feb 28

Very nice work showing fusion intermediates of SARS-CoV-2!

cryoEM papers @cryoempapers.bsky.social · Feb 28

Unveiling the Complete Spectrum of SARS-CoV-2 Fusion Stages by In Situ Cryo-ET www.biorxiv.org/content/10.1101/2025.02.25.640151v1 #cryoem

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Reposted by Chlanda lab

Jana Kroll @janakroll.bsky.social · Feb 12

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...

We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

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