Lightnews — Scholar-powered news

Reposted by Zunlong Ke

Gesa Hoffmann @gesahoffmann.bsky.social · 16h

It was wonderful to have Bijun with us @mpi-mp-potsdam.bsky.social & @incavirus.bsky.social to finally "use our microscope to its full potential" as our core-facility put it! 🔬

Congrats to all, esp. @bijuntang.bsky.social and @xanderjones.bsky.social ! Super happy to be a part of this great story!

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Jim Rowe @botanicaljim.bsky.social · 14h

I was tremendously lucky to be in @xanderjones.bsky.social's lab to watch @bijuntang.bsky.social move from technician to PhD to Postdoc and produce this magnum opus. #SalicS1 is the just reward for years of brilliance and hard work.Well done Bijun, Xander, Jing, and everyone involved! #SalicylicAcid

Sainsbury Laboratory Cambridge University (SLCU) @slcuplants.bsky.social · 1d

Salicylic acid biosensor, SalicS1, tracks the plant immune hormone salicylic acid in real time - revealing propagation of hormone surge during plant pathogen advance

Latest biosensor from @xanderjones.bsky.social team
In Science doi.org/10.1126/scie...
Summary www.slcu.cam.ac.uk/news/new-bio...

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Zunlong Ke @zunlongke.bsky.social · 18h

Really cool story on a FRET biosensor by Bijun Tang @bijuntang.bsky.social and an amazing team, now published @science.org
I’m so proud of your PhD work at @slcuplants.bsky.social
Below is the lockdown time in 2020 when you spent long hours screening your FRET biosensor, now known as SalicS1!

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Jason McLellan @mclellanlab.bsky.social · 2d

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Texas Science @texasscience.bsky.social · 2d

UT Austin has a new “genius grant” recipient!

Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation.

#TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social
cns.utexas.edu/news/accolad...

Virus Slayer Awarded ‘Genius Grant’ by MacArthur Foundation

The award recognizes Jason McLellan’s work to investigate how viruses infect our cells and to develop new treatments for infectious disease.

cns.utexas.edu

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Briggs Group @briggsgroup.bsky.social · 4d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Katie Downes @dr-downes.bsky.social · Jul 30

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

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Max Planck Institute of Biophysics @mpibp.bsky.social · Aug 18

We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...

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Jan-Hannes Schaefer @jhschaef.bsky.social · 5d

Helical Reconstruction of Amyloids in cryoSPARC?
We present guidelines, limitations & future perspectives for processing amyloids in cryoSPARC @structurabio.bsky.social.
Great collaboration of the Kelly Lab and @landerlab.bsky.social #cryoEM #amyloid www.biorxiv.org/content/10.1...

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Oli Clarke @olibclarke.bsky.social · 14d

Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup).

A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.

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Jan-Hannes Schaefer @jhschaef.bsky.social · Aug 1

Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN

CryoSift – An accessible and automated CNN-driven
tool for cryo-EM 2D class selection

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Johan Duchêne @johanduchene.bsky.social · 11d

⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?

Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk

Tested by @ycharos.bsky.social & @oga-community.bsky.social

OGA - Only Good Antibodies Community

onlygoodantibodies.co.uk

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Merja Joensuu @joensuulab.bsky.social · 9d

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

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Florian Schur @schurlab.bsky.social · 15d

Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin

doi.org/10.1126/scia...

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Lars-Anders Carlson @lacarlson.bsky.social · 15d

Cool people, cool machines - and the burning question: what barber grooms those beards to perfection?

Max Planck Institute of Biochemistry @mpibiochem.bsky.social · 15d

𝗖𝘂𝗿𝗶𝗼𝘂𝘀 𝗵𝗼𝘄 𝘄𝗲 𝘂𝘀𝗲 𝗵𝗶𝗴𝗵-𝘁𝗲𝗰𝗵 𝘁𝗼 𝗮𝗱𝘃𝗮𝗻𝗰𝗲 𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵?
Then join us at our Open Day and get exciting sneak peaks behind the scenes of one of Europe’s largest life science campuses in Martinsried.

Find out more (in German): mpi.lineupr.com/tdot/

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Da-Neng Wang @danengw.bsky.social · 16d

Congratulations, Yifan, for the Anatrace Award! Yifan’s work on the TRPV1 structure with David Julius helped launch the Resolution Revolution in cryo-EM. Not just in membrane proteins—hardly any area of biophysics today has remained untouched by the techniques Yifan pioneered.

Biophysical Society @biophysicalsoc.bsky.social · 16d

Yifan Cheng to Receive 2026 Anatrace Membrane Protein Award buff.ly/ooI1UDy

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Pacific Northwest Cryo-EM Center (PNCC) @pacificnwcryoem.bsky.social · 17d

#Training 👨‍🏫 🧑‍🏫
#CryoEM ❄️ 🔬
#Science 🧬 🦠
#Education 📚

Huge shoutout to our SPoCs for making this a grand success! 👏
Marzia Miletto
Marcelo Alexandre de Farias
Omar Davulcu

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Caitie McCafferty @computingcaitie.bsky.social · 17d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Misha Kudryashev @mishakudryashev.bsky.social · 18d

We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.

We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography

zenodo.org/records/1717...

Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles

zenodo.org

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Sjors Scheres @sjorsscheres.bsky.social · 19d

These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.

Oli Clarke @olibclarke.bsky.social · 27d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Arjen Jakobi @cryotud.bsky.social · Mar 31

CEMOVIS revisited! 🙂

bioRxiv Biophysics @biorxiv-biophys.bsky.social · Mar 31

In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS https://www.biorxiv.org/content/10.1101/2025.03.29.646093v1

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Sjors Scheres @sjorsscheres.bsky.social · Aug 12

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳

How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.

www.cell.com/structure/fu...

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

www.cell.com

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Elisa Fadda @elisafadda.bsky.social · Nov 22

I have been reading this super work ⬇️ with great interest and much enthusiasm as it discusses Ab recognition of viral glycosylation, but I don't understand how terminal GlcNAc can be a viral 'feature' as it corresponds to a stumpy human N-glycan... 1/3 #glycotime www.science.org/doi/10.1126/...

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses

Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

www.science.org

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Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · Jul 23

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

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Max Planck Institute of Biophysics @mpibp.bsky.social · Jul 25

AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...

Automated removal of corrupted tilts in cryo-electron tomography

Cryo-electron tomography (cryo-ET) enables the visualization of macromolecular structures in their near-native cellular environment. However, acquired…

www.sciencedirect.com

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Sjors Scheres @sjorsscheres.bsky.social · Aug 5

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...

www.biorxiv.org

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