Zunlong Ke
@zunlongke.bsky.social
Assistant Professor @UT Austin | Structural Virology | cryo-EM and cryo-ET | Postdoc with John Briggs @MRC_LMB @MPI_biochem | PhD with Elizabeth Wright @GeorgiaTech @Emory
Reposted by Zunlong Ke
Mechanism of membrane perforation in rotavirus cell entry www.biorxiv.org/content/10.64898/2026.01.21.700916v1 #cryoem
January 24, 2026 at 9:16 AM
Mechanism of membrane perforation in rotavirus cell entry www.biorxiv.org/content/10.64898/2026.01.21.700916v1 #cryoem
Reposted by Zunlong Ke
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...
#virology #teamtomo
www.nature.com/articles/s41...
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
www.nature.com
January 23, 2026 at 4:47 PM
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...
#virology #teamtomo
www.nature.com/articles/s41...
Reposted by Zunlong Ke
SHAPES being the key word, amirite @nanigrotjahn.bsky.social
github.com/GrotjahnLab/...
Should be an interesting #TeamTomo talk. Check it out! 🧪 🔬
github.com/GrotjahnLab/...
Should be an interesting #TeamTomo talk. Check it out! 🧪 🔬
WEBINAR: Dr. Danielle Grotjahn, Scripps Research discusses how #cryoET shapes our understanding of cellular architecture, and analyzing data to extract quantitative insights: 10 Feb, 5 PM CET | 11 Feb, 5 AM CET
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
January 23, 2026 at 12:45 PM
SHAPES being the key word, amirite @nanigrotjahn.bsky.social
github.com/GrotjahnLab/...
Should be an interesting #TeamTomo talk. Check it out! 🧪 🔬
github.com/GrotjahnLab/...
Should be an interesting #TeamTomo talk. Check it out! 🧪 🔬
Reposted by Zunlong Ke
WEBINAR: Dr. Danielle Grotjahn, Scripps Research discusses how #cryoET shapes our understanding of cellular architecture, and analyzing data to extract quantitative insights: 10 Feb, 5 PM CET | 11 Feb, 5 AM CET
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
January 23, 2026 at 11:21 AM
WEBINAR: Dr. Danielle Grotjahn, Scripps Research discusses how #cryoET shapes our understanding of cellular architecture, and analyzing data to extract quantitative insights: 10 Feb, 5 PM CET | 11 Feb, 5 AM CET
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Reposted by Zunlong Ke
Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoem
January 21, 2026 at 9:42 AM
Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoem
Reposted by Zunlong Ke
The ChimeraX DAQplugin computes DAQ scores showing the agreement between atomic models and cryoEM maps. Available from ChimeraX menu Tools / More Tools. cxtoolshed.rbvi.ucsf.edu/apps/chimera...
January 16, 2026 at 9:50 PM
The ChimeraX DAQplugin computes DAQ scores showing the agreement between atomic models and cryoEM maps. Available from ChimeraX menu Tools / More Tools. cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Reposted by Zunlong Ke
I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;
January 14, 2026 at 8:08 PM
I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;
Reposted by Zunlong Ke
Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 12, 2026 at 7:57 PM
Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Zunlong Ke
This figure captures how challenging the #cryoEM analysis was, but it doesn't capture the challenges we had to solve in molecular biology, biochemistry, purification, and functional testing. Every step was hard! So glad to see it available.
January 8, 2026 at 7:39 PM
This figure captures how challenging the #cryoEM analysis was, but it doesn't capture the challenges we had to solve in molecular biology, biochemistry, purification, and functional testing. Every step was hard! So glad to see it available.
Reposted by Zunlong Ke
NEW article by me!
We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before.
We're living through a golden age of vaccine development, but only if we continue to invest in them.
We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before.
We're living through a golden age of vaccine development, but only if we continue to invest in them.
The golden age of vaccine development - Works in Progress Magazine
The first vaccine was a lucky accident. Now we can design new vaccines in weeks, atom by atom.
worksinprogress.co
January 7, 2026 at 3:20 PM
NEW article by me!
We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before.
We're living through a golden age of vaccine development, but only if we continue to invest in them.
We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before.
We're living through a golden age of vaccine development, but only if we continue to invest in them.
Reposted by Zunlong Ke
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen pubmed.ncbi.nlm.nih.gov/41484092/ #cryoem
January 4, 2026 at 11:30 PM
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen pubmed.ncbi.nlm.nih.gov/41484092/ #cryoem
Reposted by Zunlong Ke
🌟 New Tool Alert!
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
MemPrO: A Predictive Tool for Membrane Protein Orientation
Membrane proteins play a vital role in numerous cellular processes, including ion transport, intercellular communication, and antibiotic resistance. Ensuring their accurate orientation within lipid bi...
pubs.acs.org
December 25, 2025 at 10:03 PM
🌟 New Tool Alert!
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
Reposted by Zunlong Ke
Tired of drawing cilia or centrioles for slides and papers? I feel you.
Check out CiliaBuilder for ChimeraX → cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Build custom 3D cilia & centriole models (tips + primary cilia included).
Check out CiliaBuilder for ChimeraX → cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Build custom 3D cilia & centriole models (tips + primary cilia included).
December 23, 2025 at 8:02 PM
Tired of drawing cilia or centrioles for slides and papers? I feel you.
Check out CiliaBuilder for ChimeraX → cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Build custom 3D cilia & centriole models (tips + primary cilia included).
Check out CiliaBuilder for ChimeraX → cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Build custom 3D cilia & centriole models (tips + primary cilia included).
Reposted by Zunlong Ke
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Reposted by Zunlong Ke
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
December 19, 2025 at 8:10 AM
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
Reposted by Zunlong Ke
Congratulations, Julia Mahamid!
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Und hier sind sie – die 10 Preisträger*innen des Gottfried Wilhelm #LeibnizPreis' 2026 – ausgezeichnet für ihre exzellenten Forschungsarbeiten und Errungenschaften in der Wissenschaft! 🏆👏
Die Verleihung der Preise feiern wir am 18. März in Berlin.
Einzelheiten & Kurzprofile: sohub.io/1uv1
Die Verleihung der Preise feiern wir am 18. März in Berlin.
Einzelheiten & Kurzprofile: sohub.io/1uv1
December 11, 2025 at 10:12 AM
Congratulations, Julia Mahamid!
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Reposted by Zunlong Ke
This week, check out a new #Primer on #cryogenic electron tomography (cryo-ET) used for visualizing 3D structures of cells with sub-nanometer resolution. 🔬🧫
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Correlative cryogenic light and electron tomography of eukaryotic cells - Nature Reviews Methods Primers
Cryogenic electron tomography provides unparalleled insights into cell biology and disease. When combined with light microscopy, it enables precise localization of regions of interest and direct corre...
www.nature.com
December 11, 2025 at 3:54 PM
This week, check out a new #Primer on #cryogenic electron tomography (cryo-ET) used for visualizing 3D structures of cells with sub-nanometer resolution. 🔬🧫
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Zunlong Ke
IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1
December 11, 2025 at 11:32 AM
IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1
Reposted by Zunlong Ke
Reposted by Zunlong Ke
Calling all postdocs! Applications are open for Dept. of Molecular Biosciences 3rd Trailblazers Postdoctoral Symposium @utaustin.bsky.social. Come to Austin, meet your peers, showcase your work. Application is easy and all expenses are paid! Spread the word!
tinyurl.com/yw7ffjn9
tinyurl.com/yw7ffjn9
Microsoft Forms
tinyurl.com
December 10, 2025 at 6:27 PM
Calling all postdocs! Applications are open for Dept. of Molecular Biosciences 3rd Trailblazers Postdoctoral Symposium @utaustin.bsky.social. Come to Austin, meet your peers, showcase your work. Application is easy and all expenses are paid! Spread the word!
tinyurl.com/yw7ffjn9
tinyurl.com/yw7ffjn9
Reposted by Zunlong Ke
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
$100 million prize goes to dynamic duo aiming to stop next pandemic before it starts
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
n.pr
November 22, 2025 at 8:03 PM
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
Reposted by Zunlong Ke
Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁♀️💎✨VIP section💅🪩🥂
Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.
s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.
s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
Prohibitin complexes associate with unique membrane microdomains in cells https://www.biorxiv.org/content/10.1101/2025.11.14.688579v1
November 17, 2025 at 12:22 AM
Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁♀️💎✨VIP section💅🪩🥂
Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.
s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.
s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
Reposted by Zunlong Ke
IFL Science: “Lupus Linked To Virus That Over 95 Percent Of Us Carry – And Now We Finally Know How”
"We think it applies to 100% of lupus”
cases."
www.iflscience.com/lupus-linked...
"We think it applies to 100% of lupus”
cases."
www.iflscience.com/lupus-linked...
Lupus Linked To Virus That Over 95 Percent Of Us Carry – And Now We Finally Know How
"We think it applies to 100% of lupus cases."
www.iflscience.com
November 14, 2025 at 12:09 AM
IFL Science: “Lupus Linked To Virus That Over 95 Percent Of Us Carry – And Now We Finally Know How”
"We think it applies to 100% of lupus”
cases."
www.iflscience.com/lupus-linked...
"We think it applies to 100% of lupus”
cases."
www.iflscience.com/lupus-linked...
Reposted by Zunlong Ke
MPI–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
MPI-WIS postdoc application
Max-Planck–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using recombinant pr...
forms.gle
November 13, 2025 at 4:31 PM
MPI–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Reposted by Zunlong Ke
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
Already among the most powerful artificial intelligence hubs in academia, the UT Center for Generative AI is keeping its foot on the gas. “It’s exciting to accelerate discovery and to create more opportunities for our researchers to push the boundaries of what’s possible.”
UT Doubles Size of One of World’s Most Powerful AI Computing Hubs
AUSTIN, Texas — The Center for Generative AI at The University of Texas at Austin, already among the most powerful artificial intelligence hubs in the
news.utexas.edu
November 10, 2025 at 10:54 PM
Excited for Adam Klivans and my other colleagues at UT working in the AI space!