Vanni Lab at UNIFR, Switzerland
@labvanni.bsky.social
Computational biophysics and other amenities...
"More thinking and less pipetting"
"More thinking and less pipetting"
Pinned
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Reposted by Vanni Lab at UNIFR, Switzerland
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vanni Lab at UNIFR, Switzerland
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Vanni Lab at UNIFR, Switzerland
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: [email protected]
October 22, 2025 at 2:55 PM
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: [email protected]
Reposted by Vanni Lab at UNIFR, Switzerland
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Vanni Lab at UNIFR, Switzerland
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Vanni Lab at UNIFR, Switzerland
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!
October 13, 2025 at 2:17 PM
Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!
Reposted by Vanni Lab at UNIFR, Switzerland
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Uni Bern: Assistant Professor with tenure-track for Quantitative Cell Biology
Start date of employment: anticipated for August 2027
ohws.prospective.ch
October 7, 2025 at 11:17 AM
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Reposted by Vanni Lab at UNIFR, Switzerland
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
September 10, 2025 at 4:56 AM
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Reposted by Vanni Lab at UNIFR, Switzerland
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
August 21, 2025 at 10:03 AM
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Reposted by Vanni Lab at UNIFR, Switzerland
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Open positions
GR-SCHUHMACHER
www.epfl.ch
August 12, 2025 at 9:32 AM
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
August 7, 2025 at 8:45 AM
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
July 23, 2025 at 11:40 AM
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Reposted by Vanni Lab at UNIFR, Switzerland
Hey there!✨I’m thrilled to share that our latest research, in collaboration with the Tontonoz Lab (UCLA), has just been published in Nature Metabolism. Our study explores the fascinating role of polyunsaturated fatty acids in fat storage. Check it out!
@labvanni.bsky.social
@natmetabolism.nature.com
@labvanni.bsky.social
@natmetabolism.nature.com
July 1, 2025 at 4:30 PM
Hey there!✨I’m thrilled to share that our latest research, in collaboration with the Tontonoz Lab (UCLA), has just been published in Nature Metabolism. Our study explores the fascinating role of polyunsaturated fatty acids in fat storage. Check it out!
@labvanni.bsky.social
@natmetabolism.nature.com
@labvanni.bsky.social
@natmetabolism.nature.com
Reposted by Vanni Lab at UNIFR, Switzerland
I am looking to hire a protein #biochemist, #biophysicist or structural biologist: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
Postdoctoral fellowship in protein biochemistry and biophysics - DTU Chemistry
Do you want to contribute to an exciting chemical biology project? This postdoctoral fellowship deals with the synthesis of probes aimed at studying cholesterol transport proteins in health and diseas...
efzu.fa.em2.oraclecloud.com
June 23, 2025 at 12:40 PM
I am looking to hire a protein #biochemist, #biophysicist or structural biologist: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
Reposted by Vanni Lab at UNIFR, Switzerland
Learn about #LipidDroplet #biology, their role in human disease and more at EMBO Workshop "Lipid Droplets: Cell-Biological Control of #Metabolism" in Sant Feliu de Guíxols, Spain, 21–26 September 2025
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Lipid Droplets: Cell-Biological Control of Metabolism
Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…
meetings.embo.org
June 4, 2025 at 6:14 AM
Learn about #LipidDroplet #biology, their role in human disease and more at EMBO Workshop "Lipid Droplets: Cell-Biological Control of #Metabolism" in Sant Feliu de Guíxols, Spain, 21–26 September 2025
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Reposted by Vanni Lab at UNIFR, Switzerland
Cette année le @cnrs.fr ouvre une Chaire de Professeur Junior "Méthodes de modélisation et simulations moléculaires" pour rejoindre à labo à Toulouse (@laascnrs.bsky.social), Palaiseau (LIX) ou Nancy (LORIA), vous avez jusqu'au 14 juillet pour candidater !
emploi.cnrs.fr/Offres/CPJ/C...
emploi.cnrs.fr/Offres/CPJ/C...
Portail Emploi CNRS - Offre d'emploi - Méthodes de modélisation et de simulation moléculaire H/F
emploi.cnrs.fr
May 26, 2025 at 11:47 AM
Cette année le @cnrs.fr ouvre une Chaire de Professeur Junior "Méthodes de modélisation et simulations moléculaires" pour rejoindre à labo à Toulouse (@laascnrs.bsky.social), Palaiseau (LIX) ou Nancy (LORIA), vous avez jusqu'au 14 juillet pour candidater !
emploi.cnrs.fr/Offres/CPJ/C...
emploi.cnrs.fr/Offres/CPJ/C...
Reposted by Vanni Lab at UNIFR, Switzerland
Excited to share the new work from the Carvalho lab @dunnschool.bsky.social! 🎉This was part of my PhD & a collaboration with the @labvanni.bsky.social & Ernst labs!
Big thanks to everyone involved! 🙌 @jcb.org
Read more: doi.org/10.1083/jcb.... (1/2)
Big thanks to everyone involved! 🙌 @jcb.org
Read more: doi.org/10.1083/jcb.... (1/2)
Pex30-like proteins function as adaptors at distinct ER membrane contact sites | Journal of Cell Biology | Rockefeller University Press
Membrane contact sites (MCSs) between the ER and other organelles, such as lipid droplets and peroxisomes, are essential for lipid homeostasis. This study
doi.org
May 23, 2025 at 2:40 PM
Excited to share the new work from the Carvalho lab @dunnschool.bsky.social! 🎉This was part of my PhD & a collaboration with the @labvanni.bsky.social & Ernst labs!
Big thanks to everyone involved! 🙌 @jcb.org
Read more: doi.org/10.1083/jcb.... (1/2)
Big thanks to everyone involved! 🙌 @jcb.org
Read more: doi.org/10.1083/jcb.... (1/2)
Indeed, Marc and Yuta are great!! Happy to have contributed to this story with superstar PhD @cristianrocharoa.bsky.social. For lovers of (polyunsaturated) lipids, mitochondria, fat and molecular mechanisms!
Check out the preprint of these two amazing scientists, fat-biologists, and superstar former postdocs Yuta and Marc (BlueSky-less users)!
Super excited to see this story out.
www.biorxiv.org/content/10.1...
Super excited to see this story out.
www.biorxiv.org/content/10.1...
A cold-inducible phospholipid—protein interaction in brown fat mitochondria optimizes thermogenic capacity
Cold stress elicits dynamic remodeling of the mitochondrial lipidome in brown adipose tissue (BAT), marked by an increase in arachidonoyl–phosphatidylethanolamine (AA–PE). However, the function of mem...
www.biorxiv.org
May 20, 2025 at 4:12 PM
Indeed, Marc and Yuta are great!! Happy to have contributed to this story with superstar PhD @cristianrocharoa.bsky.social. For lovers of (polyunsaturated) lipids, mitochondria, fat and molecular mechanisms!
Reposted by Vanni Lab at UNIFR, Switzerland
Check out two great preprints from the Tontonoz lab, linking LPCAT3-mediated phospholipid remodeling to dietary fat intake and cold response
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling
Complex genetic and dietary cues contribute to the development of obesity, but how these are integrated on a molecular level is incompletely understood. Here, we show that PPARγ supports hypertrophic ...
www.biorxiv.org
May 19, 2025 at 7:37 PM
Check out two great preprints from the Tontonoz lab, linking LPCAT3-mediated phospholipid remodeling to dietary fat intake and cold response
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vanni Lab at UNIFR, Switzerland
ICYMI: New online: Structural clues about bridge-mediated lipid transfer
Structural clues about bridge-mediated lipid transfer
Nature Structural & Molecular Biology, Published online: 15 May 2025; doi:10.1038/s41594-025-01552-2Some evolutionarily related proteins function as bridges at contact sites between intracellular membranes to allow bulk flow of phospholipids between them. A structural study provides key insight into how lipids are extracted from the donor bilayer and arranged in the transfer channel.
go.nature.com
May 16, 2025 at 10:23 AM
ICYMI: New online: Structural clues about bridge-mediated lipid transfer
Reposted by Vanni Lab at UNIFR, Switzerland
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
May 14, 2025 at 8:57 AM
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Reposted by Vanni Lab at UNIFR, Switzerland
PFAS surfactants self-assemble into vesicles. Exciting results based on Martini simulations from Bei Yan, highlighted in Nature:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
May 9, 2025 at 9:53 AM
PFAS surfactants self-assemble into vesicles. Exciting results based on Martini simulations from Bei Yan, highlighted in Nature:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Happy to share the latest from the lab, with @lizconibear.bsky.social lab. The title says it all: we identified poorly characterised TMEM170 proteins as lipid scramblases that physically associate in the ER with BLTP1/LPD-3/Csf1. We think this has key implications in lipid transport/homeostasis...
TMEM170 family proteins are lipid scramblases that physically associate with bridge lipid transporters BLTP1/Csf1 https://www.biorxiv.org/content/10.1101/2025.04.30.651444v1
May 2, 2025 at 2:50 PM
Happy to share the latest from the lab, with @lizconibear.bsky.social lab. The title says it all: we identified poorly characterised TMEM170 proteins as lipid scramblases that physically associate in the ER with BLTP1/LPD-3/Csf1. We think this has key implications in lipid transport/homeostasis...