Pablo Laborda
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pablolaborda.bsky.social
Pablo Laborda
@pablolaborda.bsky.social
320 followers 100 following 15 posts
Postdoctoral researcher at DTU | Ecology and evolution of antibiotic resistance and infection microbiology of Pseudomonas aeruginosa
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Reposted by Pablo Laborda
olayarendueles.bsky.social
The @imili-micro.bsky.social project is such a beautiful and necessary initiative!

I am really glad we could contribute.

Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text

- @cbitoulouse.bsky.social
November 20, 2025 at 1:26 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...
November 19, 2025 at 9:46 AM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-11:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...
November 19, 2025 at 8:49 AM
Reposted by Pablo Laborda
kentimmis.bsky.social
The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays.

www.semicrobiologia.org/revista-noti...
November 17, 2025 at 10:55 AM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5
@pablolaborda.bsky.social

How we can fight AMR

imili.org/new_gallerie...

@sbigot.bsky.social
November 11, 2025 at 12:23 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6
@pablolaborda.bsky.social, @crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...
November 11, 2025 at 12:27 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...
November 11, 2025 at 12:30 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...
November 11, 2025 at 12:46 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...
November 11, 2025 at 12:50 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:20 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:18 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:16 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1
@pablolaborda.bsky.social
imili.org/pdf/Antimicr...
November 7, 2025 at 4:10 PM
pablolaborda.bsky.social
New preprint out! 📣🚨

We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠

#Microsky
biorxiv-microbiol.bsky.social bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Oct 25
Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1
October 25, 2025 at 12:29 PM
Reposted by Pablo Laborda
pbernalt6ss.bsky.social
We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫
imili-micro.bsky.social International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · Sep 23
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
September 23, 2025 at 7:19 PM
Reposted by Pablo Laborda
imili-micro.bsky.social
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
September 23, 2025 at 6:45 PM
Reposted by Pablo Laborda
aliciapcv.bsky.social
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
rdcu.be
August 20, 2025 at 1:25 PM
Reposted by Pablo Laborda
jorgesastred.bsky.social
New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
www.biorxiv.org
August 13, 2025 at 6:26 AM
Reposted by Pablo Laborda
jerorb.bsky.social
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?

In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!

👇 Check out all the details in Paula’s thread!

Hint: 🐇 (most of the time)
July 22, 2025 at 3:05 PM
Reposted by Pablo Laborda
cserna.bsky.social
Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉

🧵 (1/14)

www.doi.org/10.1038/s414...
Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications
The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...
www.doi.org
July 17, 2025 at 12:13 PM
Reposted by Pablo Laborda
jerorb.bsky.social
🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
www.nature.com
July 2, 2025 at 11:08 AM
Reposted by Pablo Laborda
cnb-csic.bsky.social
Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT
June 4, 2025 at 9:50 AM
Reposted by Pablo Laborda
hernando-amado.bsky.social
Aquí os cuentan mis compañeras Susana de Lucas y Jennifer Palencia, de Comunicación y Cultura Científica del @cnb-csic.bsky.social, nuestro último trabajo. Describimos una estrategia de base evolutiva para eliminar la resistencia a ciprofloxacino en aislados clínicos de P. aeruginosa. Felices! 🤩
cnb-csic.bsky.social Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · Jun 4
Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT
June 4, 2025 at 10:13 AM
pablolaborda.bsky.social
Check out this cool collaboration with @hernando-amado.bsky.social, just out in @natcomms.nature.com!
We show that ciprofloxacin resistance rapidly declines in clinical P. aeruginosa strains under drug-free conditions, suggesting that ciprofloxacin restriction periods could help in clinics 🦠🧫
June 4, 2025 at 9:38 AM
Reposted by Pablo Laborda
hernando-amado.bsky.social
Ceftazidime-avibactam (a last resort drug) use selects multidrug-resistance and prevents designing collateral sensitivity based therapies against P. aeruginosa (no robust patterns emerge). Happy to see it published! 🥳 @cnb-csic.bsky.social @idisba.bsky.social
www.nature.com/articles/s41...
Ceftazidime-avibactam use selects multidrug-resistance and prevents designing collateral sensitivity-based therapies against Pseudomonas aeruginosa - Nature Communications
Ceftazidime-avibactam is a β-lactam/β-lactamase inhibitor combination restricted for the treatment of multidrug-resistant infections of Pseudomonas aeruginosa non-susceptible to ceftazidime and resist...
www.nature.com
April 9, 2025 at 9:47 AM