@perbullough.bsky.social
Reposted
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic…
plos.io
November 21, 2025 at 8:55 AM
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Reposted
There's just over 2 weeks left to apply for a fully funded PhD studentship with us working on C. difficile vancomycin resistance. Two more studentships - linked in the thread below - close in early January
November 19, 2025 at 1:45 PM
There's just over 2 weeks left to apply for a fully funded PhD studentship with us working on C. difficile vancomycin resistance. Two more studentships - linked in the thread below - close in early January
Reposted
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute
Objectives To determine the overall rate of loss of workplace teaspoons and whether attrition and displacement are correlated with the relative value of the teaspoons or type of tearoom. Design Longitudinal cohort study. Setting Research institute ...
pmc.ncbi.nlm.nih.gov
November 20, 2025 at 3:44 AM
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
November 7, 2025 at 12:49 PM
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
Reposted
Nottingham university to close its Microbiology course ☹️
Nottingham to suspend music and modern foreign language degrees, warning international fee levy will wipe out income from domestic fee rise. Some nursing, theology, education, microbiology and agriculture degrees hit too www.timeshighereducation.com/news/notting... via @julietterowsell.bsky.social
Nottingham suspends music, language and nursing courses
University says financial uncertainties continue as government’s proposed student levy will ‘wipe out any benefits’ from rising tuition fees
www.timeshighereducation.com
November 6, 2025 at 5:23 PM
Nottingham university to close its Microbiology course ☹️
Reposted
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oQ8bxO
go.nature.com/4oQ8bxO
Powerful new antibiotic that can kill superbugs discovered in soil bacteria
Surprise discovery could pave the way for new treatments against drug-resistant infections.
go.nature.com
October 31, 2025 at 5:17 PM
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oQ8bxO
go.nature.com/4oQ8bxO
Reposted
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
October 22, 2025 at 4:41 PM
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Reposted
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum pubmed.ncbi.nlm.nih.gov/41099714/ #cryoem
October 18, 2025 at 12:46 AM
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum pubmed.ncbi.nlm.nih.gov/41099714/ #cryoem
Beautiful CryoEM work by our University of Sheffield colleagues @molmicrosheffield.bsky.social
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum
Abstract. Plasmodium falciparum is a eukaryotic pathogen responsible for the majority of malaria-related fatalities. Plasmodium belongs to the phylum Apico
academic.oup.com
October 17, 2025 at 9:53 AM
Beautiful CryoEM work by our University of Sheffield colleagues @molmicrosheffield.bsky.social
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Reposted
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
October 8, 2025 at 1:15 PM
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
Reposted
Antimicrobial resistance is projected to cause 39 million deaths worldwide over the next 25 years
go.nature.com/42x5KHD
go.nature.com/42x5KHD
The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts
Data reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.
go.nature.com
October 7, 2025 at 4:26 PM
Antimicrobial resistance is projected to cause 39 million deaths worldwide over the next 25 years
go.nature.com/42x5KHD
go.nature.com/42x5KHD
Reposted
Reposted
Long-standing institutions are ill-equipped to cope with modern financial and political challenges
go.nature.com/46xZrVl
go.nature.com/46xZrVl
How universities came to be — and why they are in trouble now
What and who universities are for has changed considerably since the Second World War, leaving long-standing institutions ill-equipped to cope with current financial and political challenges.
go.nature.com
September 25, 2025 at 8:55 AM
Long-standing institutions are ill-equipped to cope with modern financial and political challenges
go.nature.com/46xZrVl
go.nature.com/46xZrVl
Reposted
Things today's White House autism announcement did not do:
-Discuss strategies to increase supports and services for autistic people/families
-Highlight why autistic people and families deserve respect, not pity or fear
-Endorse one speck of autism research that is not dangerous pseudoscience
-Discuss strategies to increase supports and services for autistic people/families
-Highlight why autistic people and families deserve respect, not pity or fear
-Endorse one speck of autism research that is not dangerous pseudoscience
September 23, 2025 at 12:57 AM
Things today's White House autism announcement did not do:
-Discuss strategies to increase supports and services for autistic people/families
-Highlight why autistic people and families deserve respect, not pity or fear
-Endorse one speck of autism research that is not dangerous pseudoscience
-Discuss strategies to increase supports and services for autistic people/families
-Highlight why autistic people and families deserve respect, not pity or fear
-Endorse one speck of autism research that is not dangerous pseudoscience
Reposted
Half a million people die from Strep A each year globally.
Now, for the first time, Scientists have discovered how some children develop natural immunity to a bacterial infection, a vital breakthrough which could help develop vaccines.
Read more: sheffield.ac.uk/news/breakth...
Now, for the first time, Scientists have discovered how some children develop natural immunity to a bacterial infection, a vital breakthrough which could help develop vaccines.
Read more: sheffield.ac.uk/news/breakth...
Breakthrough raises hopes for Strep A vaccine that could save half a million lives globally
Scientists have discovered how some children develop natural immunity to a bacterial infection, a vital breakthrough which could help develop vaccines to save up to half a million lives globally each…
sheffield.ac.uk
August 8, 2025 at 1:30 PM
Half a million people die from Strep A each year globally.
Now, for the first time, Scientists have discovered how some children develop natural immunity to a bacterial infection, a vital breakthrough which could help develop vaccines.
Read more: sheffield.ac.uk/news/breakth...
Now, for the first time, Scientists have discovered how some children develop natural immunity to a bacterial infection, a vital breakthrough which could help develop vaccines.
Read more: sheffield.ac.uk/news/breakth...
Reposted
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
July 14, 2025 at 12:10 PM
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Reposted
Quantum mechanics is one of the most successful theories in science — and makes much of modern life possible
go.nature.com/4mjXRg3
go.nature.com/4mjXRg3
Physicists disagree wildly on what quantum mechanics says about reality, Nature survey shows
Nature - First major attempt to chart researchers’ views finds interpretations in conflict.
go.nature.com
August 2, 2025 at 1:36 PM
Quantum mechanics is one of the most successful theories in science — and makes much of modern life possible
go.nature.com/4mjXRg3
go.nature.com/4mjXRg3
Reposted
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
July 22, 2025 at 7:03 PM
Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
Reposted
LMB Director Jan Löwe welcomes UK Global Talent Fund announcement:
"Global talent has always driven LMB breakthroughs. We welcome efforts to remove barriers for researchers wishing to relocate - diverse minds fuel innovation and helps us stay globally competitive."
tinyurl.com/3wahmr27
#LMBinthenews
"Global talent has always driven LMB breakthroughs. We welcome efforts to remove barriers for researchers wishing to relocate - diverse minds fuel innovation and helps us stay globally competitive."
tinyurl.com/3wahmr27
#LMBinthenews
Leading lights of UK research spearhead search for world's best talent
12 leading universities and research institutions selected to deliver government’s £54 million fund to recruit world’s top researchers.
tinyurl.com
July 18, 2025 at 9:57 AM
LMB Director Jan Löwe welcomes UK Global Talent Fund announcement:
"Global talent has always driven LMB breakthroughs. We welcome efforts to remove barriers for researchers wishing to relocate - diverse minds fuel innovation and helps us stay globally competitive."
tinyurl.com/3wahmr27
#LMBinthenews
"Global talent has always driven LMB breakthroughs. We welcome efforts to remove barriers for researchers wishing to relocate - diverse minds fuel innovation and helps us stay globally competitive."
tinyurl.com/3wahmr27
#LMBinthenews
Reposted
One free-wheeling 1930s cafe nurtured mathematical ideas including the theory of the nuclear bomb
go.nature.com/3GQIqgg
go.nature.com/3GQIqgg
‘Controlled chaos’: how to create an environment that fosters genius
One free-wheeling 1930s cafe nurtured mathematical ideas including the theory of the nuclear bomb. That holds lessons for how to spur creative thought today.
go.nature.com
July 17, 2025 at 2:48 PM
One free-wheeling 1930s cafe nurtured mathematical ideas including the theory of the nuclear bomb
go.nature.com/3GQIqgg
go.nature.com/3GQIqgg
Reposted
We’re hiring a postdoc! 🔬
Join us in Bristol, UK to study in situ structural immunology using cryoFIB-SEM + cryoET on our new Hydra Bio system. ERC-funded, 3 years, studying phagocytosis to develop new immunotherapeutics.
Closing 29 July 2025.
Info + apply: www.bristol.ac.uk/jobs/find/de...
Join us in Bristol, UK to study in situ structural immunology using cryoFIB-SEM + cryoET on our new Hydra Bio system. ERC-funded, 3 years, studying phagocytosis to develop new immunotherapeutics.
Closing 29 July 2025.
Info + apply: www.bristol.ac.uk/jobs/find/de...
Details | Working at Bristol | University of Bristol
www.bristol.ac.uk
July 9, 2025 at 2:56 PM
We’re hiring a postdoc! 🔬
Join us in Bristol, UK to study in situ structural immunology using cryoFIB-SEM + cryoET on our new Hydra Bio system. ERC-funded, 3 years, studying phagocytosis to develop new immunotherapeutics.
Closing 29 July 2025.
Info + apply: www.bristol.ac.uk/jobs/find/de...
Join us in Bristol, UK to study in situ structural immunology using cryoFIB-SEM + cryoET on our new Hydra Bio system. ERC-funded, 3 years, studying phagocytosis to develop new immunotherapeutics.
Closing 29 July 2025.
Info + apply: www.bristol.ac.uk/jobs/find/de...
Reposted
The National Student Survey results are in and we're proud to say that we're top of the Russell Group for the third year in a row! And our Student's Union has been ranked number 1 once again.
A testament to the hard work of our brilliant University community 👏🎉
sheffield.ac.uk/news/sheffie...
A testament to the hard work of our brilliant University community 👏🎉
sheffield.ac.uk/news/sheffie...
July 9, 2025 at 12:08 PM
The National Student Survey results are in and we're proud to say that we're top of the Russell Group for the third year in a row! And our Student's Union has been ranked number 1 once again.
A testament to the hard work of our brilliant University community 👏🎉
sheffield.ac.uk/news/sheffie...
A testament to the hard work of our brilliant University community 👏🎉
sheffield.ac.uk/news/sheffie...
journals.plos.org/plosgenetics...
It was fun to have contributed to this nice work from @crodrigueslab.bsky.social
It was fun to have contributed to this nice work from @crodrigueslab.bsky.social
SpoIIIL is a forespore factor required for efficient cell-cell signalling during Bacillus subtilis sporulation
Author summary Bacterial endospores allow bacteria to survive stress, persist in the environment and seed new and recurring infections. Cell-cell signalling is a cornerstone of how bacteria develop in...
journals.plos.org
July 4, 2025 at 8:00 AM
journals.plos.org/plosgenetics...
It was fun to have contributed to this nice work from @crodrigueslab.bsky.social
It was fun to have contributed to this nice work from @crodrigueslab.bsky.social
Reposted
Checkout the latest paper from our lab in PLOS Genetics: dx.plos.org/10.1371/jour...
Thanks to our wonderful collaborators, @sgribaldo.bsky.social, @cavalab.bsky.social, @perbullough.bsky.social and Cecile Morlot.
Thanks to our wonderful collaborators, @sgribaldo.bsky.social, @cavalab.bsky.social, @perbullough.bsky.social and Cecile Morlot.
SpoIIIL is a forespore factor required for efficient cell-cell signalling during Bacillus subtilis sporulation
Author summary Bacterial endospores allow bacteria to survive stress, persist in the environment and seed new and recurring infections. Cell-cell signalling is a cornerstone of how bacteria develop in...
dx.plos.org
July 3, 2025 at 9:29 PM
Checkout the latest paper from our lab in PLOS Genetics: dx.plos.org/10.1371/jour...
Thanks to our wonderful collaborators, @sgribaldo.bsky.social, @cavalab.bsky.social, @perbullough.bsky.social and Cecile Morlot.
Thanks to our wonderful collaborators, @sgribaldo.bsky.social, @cavalab.bsky.social, @perbullough.bsky.social and Cecile Morlot.