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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 6d

Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer #mycobiome #yeast

JAMA Oncology @jamaoncology.com · 7d

Specific oral bacteria and fungi were risk factors for pancreatic cancer development, suggesting the potential use of oral microbiota as noninvasive biomarkers for identifying high-risk individuals.

ja.ma/4n9QpFm

Microbial community clusters. The figure displays a heatmap-style representation of microbial data across three clusters, categorized by oral pathogens, high/low-risk bacteria and fungi. Color intensity indicates relative abundance. Includes species names on the right.

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Reposted by Pfliegler Lab at University of Debrecen

Seamus Blackley @seamus.bsky.social · 10d

May she journey forever amongst the imperishable stars.

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 12d

Recently I revived my experimental sourdough culture from the -80C freezer and started refreshing it every day. The khachapuri made with it tonight looks quite good:) #yeast

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 13d

Wow this is absoletely surprising! Sounds really strange and interesting. Some mucor species can switch to a yeast-like form, can you check the starter culture maybe to confirm?:)

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 15d

The emerging roles of non-Saccharomyces #yeasts in fermented foods and human health - new minireview from @alexandraimre.bsky.social !

Alexandra Imre @alexandraimre.bsky.social · 16d

New minireview on non-Saccharomyces yeasts and their contribution to 🍺🍷🍞🧀 fermentations and human health 💊⚕️. With Dr. Nathan Crook we summarized some recent trends in this field that could be of interest to folks in the yeast community.

academic.oup.com/femsyr/advan...

The emerging roles of non-Saccharomyces yeasts in fermented foods and human health

Abstract. Yeasts play a crucial role in the maturation of fermented foods, with Saccharomyces cerevisiae standing out as the most prominent among them. How

academic.oup.com

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 22d

Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved #Yeast Populations! #fungalevolution #Saccharomyces new paper from @stelkens.bsky.social

Rike Stelkens @stelkens.bsky.social · 23d

We have a new paper out in Molecular Ecology, led by @devinbendixsen.bsky.social ! Reproductive isolation due to divergent ecological selection is accompanied by vast genomic instability in experimentally evolved yeast populations onlinelibrary.wiley.com/doi/10.1111/...

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Reposted by Pfliegler Lab at University of Debrecen

Lars Marius Garshol @larsga.bsky.social · 23d

Another traditional brewer has left us. Harald Storli died earlier this week. I visited the family in 2014 and it was an unforgettable experience. Harald is a great loss not just for family and friends, but also for Norwegian brewing culture.

www.garshol.priv.no/blog/297.html

Storli Gard: Norway's oldest beer? | Larsblog

Personal blog of Lars Marius Garshol.

www.garshol.priv.no

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 25d

Repeated losses of self-fertility shaped heterozygosity and polyploidy in #yeast evolution! #Saccharomyces

Gilles FISCHER @gillesfischer.bsky.social · 25d

New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...

Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution

Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...

www.biorxiv.org

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 25d

#yeast #fungalevolution

HittingerLab @hittingerlab.bsky.social · 25d

Checkout our new preprint with the @rokaslab.bsky.social!:

www.biorxiv.org/content/10.1...

doi: doi.org/10.1101/2025...

Discovery of additional ancient genome duplications in yeasts

Whole genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages[1][1],[2][2], preceding adaptive radiations in vertebrates[3][3]–[5][4], teleost fish[6][5],[7][6], and an...

www.biorxiv.org

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 26d

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation #Fungalevolution

Ákos T Kovács @evolvedbiofilm.bsky.social · 27d

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation

Penicillium solitum over 8 years in a cheese cave => green-to-white shift

@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social

www.cell.com/current-biol...

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation

Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...

www.cell.com

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Reposted by Pfliegler Lab at University of Debrecen

Renátó Kovács @renatokovacs1.bsky.social · 29d

Our latest review on the effect of tyrosol in yeast has just been published. 🔥🔥🔥🍄
link.springer.com/10.1007/s002...

The effects of tyrosol on yeasts: an overview of current knowledge - Applied Microbiology and Biotechnology

Abstract Quorum sensing is a cell density-dependent microbial communication form, which can regulate several microbial properties, including virulence, biofilm formation and cell–cell competence. The ...

link.springer.com

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 29d

Congratulations to @balintnemeth.bsky.social on his talk on thousands and thousands of #Saccharomyces genomes!

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · 29d

We arrived in Szeged for the annual miniconference of the Hungarian Genetics Society! My PhD student @balintnemeth.bsky.social will present about the #Saccharomyces Compendium and I have a poster about integrating #yeast research into BSc lab classes at the University of Debrecen :)

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Sep 7

This is going to be a very nice hop harvest:)

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Sep 3

Wow! Very interesting new analysis on #mycobiome. #yeast Kazachstania forms a causal relationship with cardiovascular disease risk in a mendelian two-sample randomization analysis!

Seth Bordenstein @symbionticism.bsky.social · Sep 2

We published a new lane of research today on human gut fungi. Shout out to 1st author @emilyvansyoc.bsky.social sky.social & @erdavenport.bsky.social For 20 years, bacteria received the lion's share of interest in the human gut. Yet we know little about the gut mycobiome. doi.org/10.1371/jour...

Gut fungi are associated with human genetic variation and disease risk

In contrast to decades of research on gut bacteria, human genetic determinants of the gut fungal community (mycobiome) remain understudied. This investigation presents the first GWAS on the number and...

doi.org

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Sep 1

"Did alcohol facilitate the evolution of complex societies?" Very interesting thread on a new paper!

Lars Marius Garshol @larsga.bsky.social · Sep 1

Many researchers have suggested that alcohol may have been an important factor in developing early states. Basically, it's supposed to have helped social cohesion, improved cooperation, and reduced friction among people living cramped together.

Well, did it? New research on the subject out now.

Screenshot of paper: "Did alcohol facilitate the evolution of complex societies?
Václav Hrnčíř, Angela M. Chira & Russell D. Gray
Humanities and Social Sciences Communications volume 12, Article number: 1091 (2025)

Abstract
The size and complexity of human societies increased dramatically over the Holocene. Researchers have proposed a variety of potential drivers of this major transition, including our predilection for alcoholic beverages. This “drunk” hypothesis argues that drinking alcohol facilitated the rise of complex societies because it promotes social bonding, increases cooperation, and enhances human creativity. At the political level, alcohol-driven feasting serves to build alliances, mobilise labour, and implement power and authority. However, systematic cross-cultural evidence for the claim is lacking. Here we test this hypothesis with a global sample of 186 largely non-industrial societies, purpose-built dataset on intoxicants and causal inference methods. We find a positive relationship between the presence of indigenous alcoholic beverages and higher levels of political complexity, measured by the number of administrative levels. The effect (albeit modest) holds even after controlling for several potential confounders, including common ancestry, spatial proximity, environmental productivity, and agricultural intensity. Our results support the idea that the group-level social benefits of traditional non-distilled fermented beverages may outweigh their disruptive effects, and that alcohol may have facilitated the evolution of human societies. However,..."

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Aug 31

Finishing up two manuscripts while brewing a gruit with smoked malts and some fresh hops. Most of the hops I will harvest a few days later :)

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Aug 25

Finally, our new -80°C freezer arrived! This is our #yeast lab now, two small rooms for my research group (one half-time and one full-time PhD-student, @balintnemeth.bsky.social, many BSc and MSc-students, and me). Looking forward to start the new semester with them very soon!

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Aug 25

Made a nice focaccia with my #yeast experimentally evolving in wheat sourdough:)

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Reposted by Pfliegler Lab at University of Debrecen

Annie Hatmaker, Ph.D. @annemakerofhats.bsky.social · Aug 18

Thrilled to share that the final chapter of my PhD with @rokaslab.bsky.social is now out in @natcomms.nature.com 🎉
Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪
rdcu.be/eAToj

Population structure in a fungal human pathogen is potentially linked to pathogenicity

Nature Communications - Genetic diversity between clinical and environmental fungal isolates of Aspergillus flavus is poorly studied. Here, the authors analysed genomic data from a global set of...

rdcu.be

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Jul 27

A fantastic natural red from Tenerife, Bodegas La Araucaria 2020 Listán negro, a typical local grape variety. I asked and the winery doesn't use yeast cultures and relies on naturally occuring #yeast

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Jul 18

@larsga.bsky.social we will know more about them soon! :)

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Jul 15

group.szbk.u-szeged.hu/minikonf/ We just registered to the Genetics mini-conference in Szeged! If you are based in Hungary, the deadline is today, there is still some time:) @balintnemeth.bsky.social will present on Saccharoymces phylogenomics, and I'll show our student #kveik and #mead projects.

Genetikai Műhelyek Magyarországon

Genetika minikonferencia

group.szbk.u-szeged.hu

Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Jul 14

Jose Paulo Sampaio & Ana Pontes review the biology of #yeast domestication - not just #Saccharomyces!

Current Biology @currentbiology.bsky.social · Jun 19

Is a world without #beer, #wine #sake #bread, #cheese livable or even imaginable?

All of these delights & more, we owe to the domestication of one particular kind of #fungi by our ancestors.

Jose Paulo Sampaio & Ana Pontes review the biology of #yeast domestication

www.cell.com/current-biol...

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Pfliegler Lab at University of Debrecen @pflieglerlab.bsky.social · Jul 10

Two additional on local fermented drinks: the Canary Islands has centuries-old sugarcane distilleries and local rum and rum-based honey liquor, ronmiel, are popular. And the most commonly found lager, Dorada, is also brewed locally, it is a typical Spanish pale lager.