Joseph Schacherer
@schacherer.bsky.social
Genetics, genomics and yeast lover
Professor of Genetics, Strasbourg University
Professor of Genetics, Strasbourg University
🚨 PhD opportunity in Strasbourg! 🚨
We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17).
🔗 imcbio-phdprogram.unistra.fr
Please spread the word or contact me if you’re interested!
We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17).
🔗 imcbio-phdprogram.unistra.fr
Please spread the word or contact me if you’re interested!
IMCBio International PhD Program
IMCBio International PhD Program - Application form
imcbio-phdprogram.unistra.fr
November 27, 2025 at 6:17 AM
🚨 PhD opportunity in Strasbourg! 🚨
We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17).
🔗 imcbio-phdprogram.unistra.fr
Please spread the word or contact me if you’re interested!
We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17).
🔗 imcbio-phdprogram.unistra.fr
Please spread the word or contact me if you’re interested!
Reposted by Joseph Schacherer
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Reposted by Joseph Schacherer
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations
Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...
www.biorxiv.org
November 25, 2025 at 3:12 PM
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
Thrilled to share our latest review! T2T assemblies are reshaping how we study genomic diversity. Pangenomes unlock structural variants, gene presence-absence, and genotype-phenotype relationship, across humans, plants, animals, and fungi.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Dynamics of genome evolution in the era of pangenome analysis
Long-read sequencing and telomere-to-telomere (T2T) assemblies have enabled the generation
of pangenomes that capture genetic diversity beyond single reference genomes. This
review highlights how T2T ...
www.cell.com
November 19, 2025 at 4:49 AM
Thrilled to share our latest review! T2T assemblies are reshaping how we study genomic diversity. Pangenomes unlock structural variants, gene presence-absence, and genotype-phenotype relationship, across humans, plants, animals, and fungi.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Joseph Schacherer
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
November 7, 2025 at 3:41 PM
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
Research briefings in @nature.com about our latest story on large genomic variations and trait diversity!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Yeast genomes show how large genomic variations affect trait diversity
Structural variants have a disproportionately large effect on traits such as growth and gene expression.
www.nature.com
November 3, 2025 at 10:46 AM
Research briefings in @nature.com about our latest story on large genomic variations and trait diversity!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Had a great visit to @cicbiogune.bsky.social. Impressive science and a welcoming atmosphere!
October 29, 2025 at 8:45 AM
Had a great visit to @cicbiogune.bsky.social. Impressive science and a welcoming atmosphere!
Reposted by Joseph Schacherer
Nature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
go.nature.com/4nVsl9z
go.nature.com/4nVsl9z
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-scale studies of Saccharomyces cerevisiae.
go.nature.com
October 20, 2025 at 6:19 PM
Nature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
go.nature.com/4nVsl9z
go.nature.com/4nVsl9z
Reposted by Joseph Schacherer
Very excited to see the final version of our kingdom-scale fungal genome defense manuscript out in @plosbiology.org !
This work has been a major project of @tbadet.bsky.social during his time in our lab.
We hope to stimulate much more exciting work on fungal TEs.
journals.plos.org/plosbiology/...
This work has been a major project of @tbadet.bsky.social during his time in our lab.
We hope to stimulate much more exciting work on fungal TEs.
journals.plos.org/plosbiology/...
October 16, 2025 at 8:46 AM
Very excited to see the final version of our kingdom-scale fungal genome defense manuscript out in @plosbiology.org !
This work has been a major project of @tbadet.bsky.social during his time in our lab.
We hope to stimulate much more exciting work on fungal TEs.
journals.plos.org/plosbiology/...
This work has been a major project of @tbadet.bsky.social during his time in our lab.
We hope to stimulate much more exciting work on fungal TEs.
journals.plos.org/plosbiology/...
Reposted by Joseph Schacherer
Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
Nature - A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable...
rdcu.be
October 15, 2025 at 9:06 PM
Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 7:49 AM
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joseph Schacherer
The #Yeast26 website is live—start planning your conference attendance now! 🧬
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
October 13, 2025 at 6:03 PM
The #Yeast26 website is live—start planning your conference attendance now! 🧬
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Reposted by Joseph Schacherer
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Looking for science and fun by the ocean next June?🧬🌊
Join at the GSA Yeast 2026 meeting in beautiful Asilomar, Pacific Grove, CA!
📅 Save the date: June 14–18, 2026
➡️ genetics-gsa.org/yeast-2026/
Join at the GSA Yeast 2026 meeting in beautiful Asilomar, Pacific Grove, CA!
📅 Save the date: June 14–18, 2026
➡️ genetics-gsa.org/yeast-2026/
Homepage - Yeast Genetics Meeting 2026
Visit our website to learn more.
genetics-gsa.org
October 10, 2025 at 5:57 AM
Looking for science and fun by the ocean next June?🧬🌊
Join at the GSA Yeast 2026 meeting in beautiful Asilomar, Pacific Grove, CA!
📅 Save the date: June 14–18, 2026
➡️ genetics-gsa.org/yeast-2026/
Join at the GSA Yeast 2026 meeting in beautiful Asilomar, Pacific Grove, CA!
📅 Save the date: June 14–18, 2026
➡️ genetics-gsa.org/yeast-2026/
Thrilled to share our latest work focusing on graph-based pangenome analysis highlighting structural and functional consequences of allopolyploidization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Graph-based pangenome analysis uncovers structural and functional impacts of allopolyploidization events
The emergence of graph pangenomes has significantly advanced the study of structural variants (SVs) across diverse species. However, the impact of complex polyploidization events, particularly allopol...
www.biorxiv.org
September 1, 2025 at 8:03 AM
Thrilled to share our latest work focusing on graph-based pangenome analysis highlighting structural and functional consequences of allopolyploidization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Joseph Schacherer
📢 Nominate your colleagues for a special lecture to be presented at the Yeast Genetics Meeting, June 13-17, 2026! It will take you 5 minutes and no need to be GSA member!
www.surveymonkey.com/r/Yeast26?ut...
www.surveymonkey.com/r/Yeast26?ut...
2026 Yeast Genetics Meeting Nominations
Take this survey powered by surveymonkey.com. Create your own surveys for free.
www.surveymonkey.com
August 26, 2025 at 6:32 PM
📢 Nominate your colleagues for a special lecture to be presented at the Yeast Genetics Meeting, June 13-17, 2026! It will take you 5 minutes and no need to be GSA member!
www.surveymonkey.com/r/Yeast26?ut...
www.surveymonkey.com/r/Yeast26?ut...
📢 Nominate your colleagues for a special lecture to be presented at the Yeast Genetics Meeting, June 13-17, 2026! It will take you 5 minutes and no need to be GSA member!
www.surveymonkey.com/r/Yeast26?ut...
www.surveymonkey.com/r/Yeast26?ut...
2026 Yeast Genetics Meeting Nominations
Take this survey powered by surveymonkey.com. Create your own surveys for free.
www.surveymonkey.com
August 26, 2025 at 6:32 PM
📢 Nominate your colleagues for a special lecture to be presented at the Yeast Genetics Meeting, June 13-17, 2026! It will take you 5 minutes and no need to be GSA member!
www.surveymonkey.com/r/Yeast26?ut...
www.surveymonkey.com/r/Yeast26?ut...
Reposted by Joseph Schacherer
Out after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 20, 2025 at 6:23 AM
Out after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Yeast2025 meeting in Paris is over, and was so much fun. It was exciting to see a room full of yeast biologists, with more than 500 people. It was also great to be part of the dream team of organizers, led by @gillesfischer.bsky.social
July 27, 2025 at 1:52 PM
The Yeast2025 meeting in Paris is over, and was so much fun. It was exciting to see a room full of yeast biologists, with more than 500 people. It was also great to be part of the dream team of organizers, led by @gillesfischer.bsky.social
Nice to have a recap of our past @erc.europa.eu PhenomeNal project. Well, let's move on to the next one - UnMiss.
cordis.europa.eu/article/id/4...
cordis.europa.eu/article/id/4...
Trait inheritance study challenges the simplicity of genes acting alone
New research shows that traits in organisms are not always inherited in straightforward ways. A gene’s effect is not isolated – it...
cordis.europa.eu
July 18, 2025 at 1:45 PM
Nice to have a recap of our past @erc.europa.eu PhenomeNal project. Well, let's move on to the next one - UnMiss.
cordis.europa.eu/article/id/4...
cordis.europa.eu/article/id/4...
Reposted by Joseph Schacherer
Great work from Horia Todor in Carol Gross's lab showing it's possible to predict complexes in "competition" pools in AF3 resulting in the first all-by-all prediction for a species. After length correcting the ipTM score predicts well known interactions and correlating ipTM vectors also has value.
Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 https://www.biorxiv.org/content/10.1101/2025.07.01.662654v1
July 5, 2025 at 5:14 AM
Great work from Horia Todor in Carol Gross's lab showing it's possible to predict complexes in "competition" pools in AF3 resulting in the first all-by-all prediction for a species. After length correcting the ipTM score predicts well known interactions and correlating ipTM vectors also has value.
Reposted by Joseph Schacherer
Wow 1000+ Brettanomyces genomes, not just from Belgium and not just from lambic! Awesome, can't wait to check the details on these #yeast s. With recent advancements from two different groups on Lachancea, more and more domesticated yeast have their population structures uncovered, not just Saccharo
The latest story from the @haploteam highlights the phenotypic impact of acquired subgenomes in allopolyploids, through the lens of 1,060 Brettanomyces bruxellensis genomes. Nice collaboration with @univbordeaux.bsky.social
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
Whole-genome sequencing of 1,060 Brettanomyces bruxellensis isolates reveals significant phenotypic impact of acquired subgenomes in allopolyploids - Nature Communications
The authors sequence and phenotype over 1,000 isolates of the yeast Brettanomyces bruxellensis, and show how allopolyploidization reshapes genome evolution and enhances phenotypic diversity, highlight...
www.nature.com
July 3, 2025 at 7:38 PM
Wow 1000+ Brettanomyces genomes, not just from Belgium and not just from lambic! Awesome, can't wait to check the details on these #yeast s. With recent advancements from two different groups on Lachancea, more and more domesticated yeast have their population structures uncovered, not just Saccharo
The latest story from the @haploteam highlights the phenotypic impact of acquired subgenomes in allopolyploids, through the lens of 1,060 Brettanomyces bruxellensis genomes. Nice collaboration with @univbordeaux.bsky.social
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
Whole-genome sequencing of 1,060 Brettanomyces bruxellensis isolates reveals significant phenotypic impact of acquired subgenomes in allopolyploids - Nature Communications
The authors sequence and phenotype over 1,000 isolates of the yeast Brettanomyces bruxellensis, and show how allopolyploidization reshapes genome evolution and enhances phenotypic diversity, highlight...
www.nature.com
July 3, 2025 at 7:08 PM
The latest story from the @haploteam highlights the phenotypic impact of acquired subgenomes in allopolyploids, through the lens of 1,060 Brettanomyces bruxellensis genomes. Nice collaboration with @univbordeaux.bsky.social
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
Beyond happy to be an ERC AdG laureate! This milestone would not have been possible without the incredible work done in the past and the dedication of all current and former members of the haploteam - www.haploteam.org
@unistra.fr @cnrsbiologie.bsky.social #IUF
bsky.app/profile/erc....
@unistra.fr @cnrsbiologie.bsky.social #IUF
bsky.app/profile/erc....
📣 Good news: 281 top researchers have just won ERC Advanced Grants!
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
June 17, 2025 at 4:10 PM
Beyond happy to be an ERC AdG laureate! This milestone would not have been possible without the incredible work done in the past and the dedication of all current and former members of the haploteam - www.haploteam.org
@unistra.fr @cnrsbiologie.bsky.social #IUF
bsky.app/profile/erc....
@unistra.fr @cnrsbiologie.bsky.social #IUF
bsky.app/profile/erc....
Reposted by Joseph Schacherer
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 2, 2025 at 10:31 AM
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...