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Reposted by Renátó Kovács

Ilan Schwartz @germhuntermd.bsky.social · 9d

Risk factors associated with progression to clinical Candida auris infection among adults with previous colonization—Florida, 2019–2023

academic.oup.com/cid/advance-...

Risk factors associated with progression to clinical Candida auris infection among adults with previous colonization—Florida, 2019–2023

We investigated factors associated with clinical progression of Candida auris cases following documented colonization among Florida patients. These finding

academic.oup.com

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Renátó Kovács @renatokovacs1.bsky.social · 29d

Our latest review on the effect of tyrosol in yeast has just been published. 🔥🔥🔥🍄
link.springer.com/10.1007/s002...

The effects of tyrosol on yeasts: an overview of current knowledge - Applied Microbiology and Biotechnology

Abstract Quorum sensing is a cell density-dependent microbial communication form, which can regulate several microbial properties, including virulence, biofilm formation and cell–cell competence. The ...

link.springer.com

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Prof. Andy Borman @andy-borman.bsky.social · Sep 5

And another:

Name changes for fungi of medical importance, 2022–2024 | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...

Name changes for fungi of medical importance, 2022–2024 | Journal of Clinical Microbiology

Since fungal identification methods based on examination of morphological and phenotypic features are complicated by the astonishing diversity of organisms capable of causing human infections especial...

journals.asm.org

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Reposted by Renátó Kovács

Alexander Lorenz @lorenzlab.bsky.social · Aug 22

Very happy to have our preprint published in Microbiological Research now doi.org/10.1016/j.mi..., we had additional help from Steven during the revision to get this over the line @chitinette.bsky.social @theafg.bsky.social @uniofaberdeen.bsky.social

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Ilan Schwartz @germhuntermd.bsky.social · Aug 19

A clinical practice guideline for tuberculous meningitis

Tuberculous Meningitis International Research Consortium

www.thelancet.com/journals/lan... 🔒

A clinical practice guideline for tuberculous meningitis

Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal mana...

www.thelancet.com

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Reposted by Renátó Kovács

Teresa O'Meara @teresaomeara.bsky.social · Jul 28

Today is a good day to read our preprint about Candida albicans interactions with its neighbors! www.biorxiv.org/content/10.1... led by the amazing Faith Davis and a fantastic team of collaborators @kylaost.bsky.social @shannonrighi.bsky.social @balunaslab.bsky.social @tuowang.bsky.social

Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi

The fungus Candida albicans commensally colonizes mucosal surfaces in healthy individuals but can cause both superficial mucosal and life-threatening disseminated infections. The balance between comme...

www.biorxiv.org

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Ákos T Kovács @evolvedbiofilm.bsky.social · Jul 19

A global perspective on autoinducer-2-mediated cell communication in prokaryotes

- in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

A global perspective on autoinducer-2-mediated cell communication in prokaryotes

Biological sciences; Molecular biology; Microbiology

www.cell.com

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European Research Council (ERC) @erc.europa.eu · Jul 10

📣 ERC Synergy Grant 2026 call for proposals is now open!

Application deadline 5 November 2025.

📝 Groups of 2-4 researchers
📝 Jointly addressing ambitious problems & with different skills

Application portal 👉 europa.eu/!XpwptY
General info 👉 europa.eu/!PR6gt8

#ERCSyG #FrontierResearch

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Reposted by Renátó Kovács

Prof. Andy Borman @andy-borman.bsky.social · Jun 23

Our new paper in JEADV describing four cases of TMVII infection in the UK:

doi.org/10.1111/jdv....

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UK Health Security Agency @ukhsa.bsky.social · May 29

🆕 Our latest data shows that bloodstream infections caused by yeast rose by 4% in 2024, compared to 2023.
These infections are typically acquired in a hospital setting from yeasts found naturally on patients' skin or in our intestinal tracts. 🦠🧍
📰🔗 www.gov.uk/government/n...

Bloodstream infections caused by yeast rose by 4% in 2024, compared to 2023 (C. auris)

Professor Andy Borman, Head of the Mycology Reference Laboratory, UKHSA

Our surveillance shows that serious fungal infections are having an increasing impact on public health.

UKHSA is working with the NHS to explore the reasons behind the rise in serious yeast infections, but factors such as an increase in people who are immunocompromised and the number of people receiving complex surgeries may be playing a part.

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Reposted by Renátó Kovács

Jon Salmanton-García @salmantongarcia.bsky.social · Jun 20

🦠 Fungi Under Fire in Peru 🇵🇪

🧪 Microscopy? Widespread.
💊 Antifungals? Some gaps.
🧬 Advanced tools? Still growing.
💡 A call for smarter investment in fungal care → journals.asm.org/doi/10.1128/...

@jmaquera2 @olivercornely.bsky.social

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Ilan Schwartz @germhuntermd.bsky.social · Jun 15

Antifungal therapy in Candida infective endocarditis: a comparison of echinocandins & other treatment regimens in a nation-wide cohort study

In this 🇸🇪 registry study, no dif in in-🏥 mort, relapse rate, or 1-yr mort in pts w/ echinocandin-based Rx vs other regimens

academic.oup.com/cid/advance-...

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Alexander V. Veselov 😷🎮 @alexxxmd.bsky.social · Jun 11

Invasive candida in the abdomen: how to differentiate infection from colonization
Corentin Deckers, et al.
Expert Review of Anti-infective Therapy, 2025
doi.org/10.1080/1478...

Invasive candida in the abdomen: how to differentiate infection from colonization

Intra-abdominal candidiasis (IAC) is a serious complication in critically ill patients, particularly after abdominal surgery or trauma. Differentiating Candida colonization from invasive infection ...

doi.org

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Ilan Schwartz @germhuntermd.bsky.social · Jun 8

Candida Endocarditis: current perspectives on diagnosis and therapy

Ben-Ami Ronen, Bassetti Matteo, Bouza Emilio, Kosman Alex, Vena Antonio on behalf of @efisg-escmid.bsky.social

www.clinicalmicrobiologyandinfection.com/article/S119... #MedMycoSky #IDSky

Candida Endocarditis: current perspectives on diagnosis and therapy

Candida infective endocarditis (CIE) is a rare but potentially devastating condition. Although it accounts for only 1-1.5% of infective endocarditis cases, CIE carries a high mortality rate (36-49%) a...

www.clinicalmicrobiologyandinfection.com

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Reposted by Renátó Kovács

Ilan Schwartz @germhuntermd.bsky.social · Jun 8

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge

@grthompsonmd.bsky.social and Angel Desai

www.nejm.org/doi/full/10....

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge | NEJM

Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.

www.nejm.org

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Reposted by Renátó Kovács

Clement Tsui PhD 🇭🇰 🇨🇦 @clementsui.bsky.social · May 28

Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance - Journal of Infection www.journalofinfection.com/article/S016...

Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance

The global burden of bloodstream infection (BSI) due to Candida, and species previously classed as Candida (Candida-like species) is substantial. Recent emergence of Candida auris, fluconazole-resista...

www.journalofinfection.com

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Clement Tsui PhD 🇭🇰 🇨🇦 @clementsui.bsky.social · Apr 17

Commensalism and pathogenesis of #Candida albicans at the mucosal interface rdcu.be/eia8o

Commensalism and pathogenesis of Candida albicans at the mucosal interface

Nature Reviews Microbiology - In this Review, Hube and colleagues overview the commensal and pathogenic lifestyles of Candida albicans, focusing on how the fungus transitions between these two...

rdcu.be

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Reposted by Renátó Kovács

Alexander V. Veselov 😷🎮 @alexxxmd.bsky.social · Apr 9

How does antifungal resistance vary in Candida (Candidozyma) auris and its clades? Quantitative and qualitative analyses and their clinical implications
Kássia Jéssica Galdino da Silva, et al.
Clinical Microbiology and Infection, 2025
www.clinicalmicrobiologyandinfection.com/article/S119...

How does antifungal resistance vary in Candida (Candidozyma) auris and its clades? Quantitative and qualitative analyses and their clinical implications

Candida auris is a multidrug-resistant yeast that emerged as a significant healthcare-associated pathogen. It is classified as an urgent threat to public health due to the high resistance to available...

www.clinicalmicrobiologyandinfection.com

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Reposted by Renátó Kovács

Ákos T Kovács @evolvedbiofilm.bsky.social · Mar 29

Current knowledge on the dual species interaction and biofilm between Aspergillus and Bacillus: exploiting molecular understanding toward applications

-in Critical Reviews in Microbiology

www.tandfonline.com/doi/full/10....

Current knowledge on the dual species interaction and biofilm between Aspergillus and Bacillus: exploiting molecular understanding toward applications

The complex interaction between Aspergillus and Bacillus has been gaining attention with the evolution of their co-culture applications. Information reported on this interaction from different poin...

www.tandfonline.com

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Oliver Cornely @olivercornely.bsky.social · Mar 13

The Paed-EQUAL Candida Score helps manage candidaemia in children & neonates by improving guideline adherence & antifungal stewardship. With rising fluconazole resistance, this tool is crucial. Learn more: onlinelibrary.wiley.com/doi/10.1111/... #PaedEQUAL #Candida

The Paediatric European Confederation of Medical Mycology (ECMM) Quality (Paed‐EQUAL) Candida Score for the Management of Candidaemia in Children and Neonates

Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of nov...

onlinelibrary.wiley.com

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Reposted by Renátó Kovács

Martin Hoenigl @martinhoenigl.bsky.social · Mar 1

Antifungal pipeline: New tools for the treatment of mycoses.
Focus on LMICs where many dont have access to current antifungals.

Updated maps on fungal availability in LMICS.

Thanks to a fantastic group of authors

www.sciencedirect.com/science/arti...

Antifungal pipeline: New tools for the treatment of mycoses

Fungal infections are becoming an escalating public health challenge, particularly among immunocompromised individuals. The partially limited efficacy…

www.sciencedirect.com

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Clement Tsui PhD 🇭🇰 🇨🇦 @clementsui.bsky.social · Mar 1

#Candidaauris had colonized the skin of all the people in nursing homes. rdcu.be/ebOhb

Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes

Nature - Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other...

rdcu.be

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Ákos T Kovács @evolvedbiofilm.bsky.social · Feb 27

New publication from our previous @cemist.bsky.social project by Rune Overlund Stannius that he also worked on during his external stay at #InstituteBiologyLeiden

Plipastatin is a shared good by Bacillus subtilis during combating Fusarium spp

academic.oup.com/femsec/advan...

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FEMS Journals @femsjournals.bsky.social · Feb 27

Check out the latest article from Kintner et al. 👇🏻 Insights into #polymicrobial #interactions in the female genital tract 🔬Role of β-glucans from #Candida in #Chlamydia infections. ⏩ https://buff.ly/3EWqdga

#PathogDis #vaginal #microbiome

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Ilan Schwartz @germhuntermd.bsky.social · Feb 25

Invasive fungal infections in patients with liver disease: immunological and clinical considerations for the intensive care unit

Epelbaum, Gallo de Moraes, Olson, & Lionakis

link.springer.com/article/10.1...

#IDSky #HepSky #MedMycoSky

Diagram of the normal innate and cellular adaptive immune responses to fungal organisms highlighting the central role of macrophages and dendritic cells (DC). Should fungi succeed in breaching the host’s external barriers, the first immune cells they encounter as part of the innate response are the professional phagocytes residing in tissues: macrophages and DCs. Macrophages are responsible for both phagocytosis and, through signaling based on molecular recognition as detailed in the figure, for elaborating pro-inflammatory cytokines, such as TNF-α and IL-1β, which attract blood-borne effector cells (neutrophils and monocytes) to the site of invasion. Likewise, DCs contribute to the innate immune response not only through phagocytosis but also by stimulating natural killer cells, which, once activated, release cytotoxins for direct pathogen elimination. The other critical function of DCs is their migration to surrounding lymph nodes, where they promote the diffe

The liver is a vital cog in human immune defenses against infection, both locally and systemically. The main immune function of the liver is antimicrobial surveillance of splanchnic blood returning from the portal circulation and flowing through liver sinusoids into hepatic venules. Kupffer cells (KC) are macrophage derivatives that reside within hepatic sinusoids where they serve as the primary phagocytes and are also very important antigen presenting cells (APCs). KCs as well as dendritic cells (DC), the other prominent APCs residing in the liver, are major producers of both pro- (e.g., TNF-α) and anti-inflammatory cytokines (e.g., IL-10) and are thus instrumental in calibrating the liver’s immune response. Unlike KCs, DCs are not confined to the lumen of hepatic sinusoids, so they are can traverse the Space of Disse and migrate to locoregional lymph nodes, where they initiate an adaptive immune response by priming naïve CD4 + lymphocytes. In the hepatic sinusoids, KCs and DCs interact with a variety of intrahepatic lymphocytes, most numerous among them being natural killer (NK) cells. Even structural cells in the liver, ie hepatocytes and sinusoidal endothelial cells, play a number of immunological roles, including elaboration of cytokines, release of soluble pattern recognition receptors, and phagocytosis. The major liver-resident cells with immune functions are depicted in the top left section of the diagram. Aside from disrupting local antimicrobial defenses, liver cirrhosis also negatively impacts the systemic immune response. Despite an overall hyperinflammatory systemic milieu, specific circulating immune cells are rendered dysfunctional in liver failure as part of a phenomenon called immune cell paralysis. Neutrophils become less effective with respect to chemotaxis and phagocytosis. The oxidative burst critical for effective pathogen elimination by monocytes is impaired, and both a quantitative & qualitative defect in T cell lymphocyte immunity develops

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