Philip Hasel
@philiphasel.bsky.social
Group Leader and Wellcome Trust Career Development Fellow at the UK Dementia Research Institute at Edinburgh University. Interested in astrocytes at brain borders.
Reposted by Philip Hasel
"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates"
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
November 18, 2025 at 1:01 AM
"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates"
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
http://dlvr.it/TPKJSH
@liddelowsa.bsky.social @philiphasel.bsky.social & colleagues
@cp-cellreports.bsky.social
#SfN2025
Reposted by Philip Hasel
Reposted by Philip Hasel
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Fig. 1: Establishment of methods to identify astrocyte endfoot proteins. | Nature Communications
www.nature.com
November 6, 2025 at 11:26 AM
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Reposted by Philip Hasel
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
October 20, 2025 at 3:28 PM
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
Reposted by Philip Hasel
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
UK Glia 2026
UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...
www.physoc.org
October 20, 2025 at 12:54 PM
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
Reposted by Philip Hasel
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
September 12, 2025 at 1:21 PM
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
Reposted by Philip Hasel
Hello world!
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.
Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits https://www.biorxiv.org/content/10.1101/2025.09.01.672986v1
September 3, 2025 at 5:41 AM
Hello world!
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.
Reposted by Philip Hasel
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 7:15 PM
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
Reposted by Philip Hasel
Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳
Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine https://www.biorxiv.org/content/10.1101/2025.06.04.657899v1
June 10, 2025 at 12:24 PM
Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳
Reposted by Philip Hasel
So grateful to the @wellcometrust.bsky.social for investing in me... believing in me. It's hard to believe in yourself sometimes. Science is going really well and I am thrilled to be back in the lab
wellcome.org/research-fun...
wellcome.org/research-fun...
Hyperpolarised 129Xe Nuclear Magnetic Resonance (NMR) Spectroscopic Brain Oximetry - Grants Awarded | Wellcome
Hyperpolarised 129Xe Nuclear Magnetic Resonance (NMR) Spectroscopic Brain Oximetry
wellcome.org
June 6, 2025 at 11:59 AM
So grateful to the @wellcometrust.bsky.social for investing in me... believing in me. It's hard to believe in yourself sometimes. Science is going really well and I am thrilled to be back in the lab
wellcome.org/research-fun...
wellcome.org/research-fun...
Reposted by Philip Hasel
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Reposted by Philip Hasel
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Philip Hasel
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!
https://ucl.ac.uk/work-at-ucl/se…
May 9, 2025 at 8:33 AM
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!
Reposted by Philip Hasel
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
May 2, 2025 at 8:05 PM
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Reposted by Philip Hasel
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
The Gleichman lab
gleichmanlab.com
May 1, 2025 at 8:24 PM
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
Reposted by Philip Hasel
So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!
Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...
rdcu.be
April 30, 2025 at 3:35 PM
So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!
Reposted by Philip Hasel
We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠
A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️
www.cell.com/immunity/ful...
A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️
www.cell.com/immunity/ful...
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell
leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular
signature of disease-associated ...
www.cell.com
April 30, 2025 at 3:39 PM
We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠
A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️
www.cell.com/immunity/ful...
A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️
www.cell.com/immunity/ful...
Reposted by Philip Hasel
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...
www.biorxiv.org
April 28, 2025 at 9:09 AM
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Reposted by Philip Hasel
A new study led by @philiphasel.bsky.social reveals the unique genetic profile of astrocytes that form the glia limitans superficialis (GLS), the thin layer of cells that covers the brain and spinal cord 🧠
Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️
Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️
The brain’s “stalwart sentinels” express an unexpected gene
The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.
buff.ly
April 15, 2025 at 4:18 PM
A new study led by @philiphasel.bsky.social reveals the unique genetic profile of astrocytes that form the glia limitans superficialis (GLS), the thin layer of cells that covers the brain and spinal cord 🧠
Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️
Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️
Master class in single cell genomics analysis from @mrodea.bsky.social
New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes.
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:
Epigenetic memory astrocytes are likely an artifact of immune cell contamination https://www.biorxiv.org/content/10.1101/2025.04.04.647246v1
April 8, 2025 at 4:36 PM
Master class in single cell genomics analysis from @mrodea.bsky.social
Reposted by Philip Hasel
I am #hiring an #MRI #physicist, please consider making an application. The job is based in #Sheffield, with extensive collaboration with #UCL. Opportunity to work at 7T & 9.4T, & undertake human imaging at 3T in parallel with the core preclinincal work.
jobsite.sheffield.ac.uk/job/Research...
jobsite.sheffield.ac.uk/job/Research...
Research Associate in Multimodal Neuroimaging and Physiological Modelling
Research Associate in Multimodal Neuroimaging and Physiological Modelling
jobsite.sheffield.ac.uk
April 7, 2025 at 5:23 AM
I am #hiring an #MRI #physicist, please consider making an application. The job is based in #Sheffield, with extensive collaboration with #UCL. Opportunity to work at 7T & 9.4T, & undertake human imaging at 3T in parallel with the core preclinincal work.
jobsite.sheffield.ac.uk/job/Research...
jobsite.sheffield.ac.uk/job/Research...
Reposted by Philip Hasel
The cell bodies of astrocytes, not their end-feet, make up the brain’s last line of defense, a new paper in Cell Reports confirms. The findings flip the standard picture of these “stalwart sentinels” of the brain.
By Lauren Schenkman
www.thetransmitter.org/astrocytes/u...
By Lauren Schenkman
www.thetransmitter.org/astrocytes/u...
The brain’s “stalwart sentinels” express an unexpected gene
The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.
www.thetransmitter.org
March 28, 2025 at 1:55 PM
The cell bodies of astrocytes, not their end-feet, make up the brain’s last line of defense, a new paper in Cell Reports confirms. The findings flip the standard picture of these “stalwart sentinels” of the brain.
By Lauren Schenkman
www.thetransmitter.org/astrocytes/u...
By Lauren Schenkman
www.thetransmitter.org/astrocytes/u...
Great story covering our description of the superficial glia limitans!
@thetransmitter.bsky.social :
www.thetransmitter.org/astrocytes/u...
@thetransmitter.bsky.social :
www.thetransmitter.org/astrocytes/u...
The brain’s “stalwart sentinels” express an unexpected gene
The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.
www.thetransmitter.org
March 28, 2025 at 12:57 PM
Great story covering our description of the superficial glia limitans!
@thetransmitter.bsky.social :
www.thetransmitter.org/astrocytes/u...
@thetransmitter.bsky.social :
www.thetransmitter.org/astrocytes/u...
Reposted by Philip Hasel
Have you seen our website:
Built and maintained by @drmyelin.bsky.social
Check it out 👀
www.glianetwork.org.uk
Built and maintained by @drmyelin.bsky.social
Check it out 👀
www.glianetwork.org.uk
Home
What is the UK Glia network?
The UK Glia network has been founded by a group of scientists representing all fields of glia research. Our primary goal is to create a community for glia researchers work...
www.glianetwork.org.uk
March 27, 2025 at 9:01 AM
Have you seen our website:
Built and maintained by @drmyelin.bsky.social
Check it out 👀
www.glianetwork.org.uk
Built and maintained by @drmyelin.bsky.social
Check it out 👀
www.glianetwork.org.uk