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Reposted by Philip Hasel

Travis Faust @travisfaust.bsky.social · 26d

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

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Reposted by Philip Hasel

sambooker.bsky.social @sambooker.bsky.social · Sep 3

Hello world!
We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 2

Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits https://www.biorxiv.org/content/10.1101/2025.09.01.672986v1

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Reposted by Philip Hasel

Ciarán Murphy-Royal @murphyroyallab.org · Sep 3

www.thetransmitter.org/astrocytes/a...

Astrocyte networks span large swaths of brain

The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

www.thetransmitter.org

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Reposted by Philip Hasel

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 22

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

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Reposted by Philip Hasel

holtlm90.bsky.social @holtlm90.bsky.social · Jun 10

Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jun 9

Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine https://www.biorxiv.org/content/10.1101/2025.06.04.657899v1

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Reposted by Philip Hasel

Isabel N Christie PhD @izzynchristie.bsky.social · Jun 6

So grateful to the @wellcometrust.bsky.social for investing in me... believing in me. It's hard to believe in yourself sometimes. Science is going really well and I am thrilled to be back in the lab

wellcome.org/research-fun...

Hyperpolarised 129Xe Nuclear Magnetic Resonance (NMR) Spectroscopic Brain Oximetry - Grants Awarded | Wellcome

Hyperpolarised 129Xe Nuclear Magnetic Resonance (NMR) Spectroscopic Brain Oximetry

wellcome.org

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Reposted by Philip Hasel

John Lukens @lukensjohnr.bsky.social · May 19

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

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Reposted by Philip Hasel

lyons-lab.bsky.social @lyons-lab.bsky.social · May 14

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience

Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

www.nature.com

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Reposted by Philip Hasel

Soyon Hong @soyonhonglab.bsky.social · May 9

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

https://ucl.ac.uk/work-at-ucl/se…

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Reposted by Philip Hasel

Leon Smyth @leonsmyth.bsky.social · May 2

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Redefining CNS immune privilege - Nature Reviews Immunology

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

www.nature.com

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Reposted by Philip Hasel

Amy Gleichman @amygleichman.bsky.social · May 1

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com

The Gleichman lab

gleichmanlab.com

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Reposted by Philip Hasel

Claire Durrant @clairedurrant1.bsky.social · Apr 30

So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!

Dr Soraya M @sorayam.bsky.social · Apr 30

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

rdcu.be

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Reposted by Philip Hasel

Will Aisenberg @waisenberg.bsky.social · Apr 30

We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠

A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️

www.cell.com/immunity/ful...

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

www.cell.com

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Reposted by Philip Hasel

Mike Dolan @dolanmjg.bsky.social · Apr 28

How does the brain repair myelin after injury?

We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...

Details below 👇

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

www.biorxiv.org

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Reposted by Philip Hasel

UK Dementia Research Institute @ukdri.ac.uk · Apr 15

A new study led by @philiphasel.bsky.social reveals the unique genetic profile of astrocytes that form the glia limitans superficialis (GLS), the thin layer of cells that covers the brain and spinal cord 🧠

Dr Hasel spoke to @thetransmitter.bsky.social about his work⬇️

The brain’s “stalwart sentinels” express an unexpected gene

The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

buff.ly

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Philip Hasel @philiphasel.bsky.social · Apr 8

Master class in single cell genomics analysis from @mrodea.bsky.social

Michael O’Dea @mrodea.bsky.social · Apr 8

New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes.

We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Apr 8

Epigenetic memory astrocytes are likely an artifact of immune cell contamination https://www.biorxiv.org/content/10.1101/2025.04.04.647246v1

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Reposted by Philip Hasel

Isabel N Christie PhD @izzynchristie.bsky.social · Apr 7

I am #hiring an #MRI #physicist, please consider making an application. The job is based in #Sheffield, with extensive collaboration with #UCL. Opportunity to work at 7T & 9.4T, & undertake human imaging at 3T in parallel with the core preclinincal work.

jobsite.sheffield.ac.uk/job/Research...

Research Associate in Multimodal Neuroimaging and Physiological Modelling

jobsite.sheffield.ac.uk

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Reposted by Philip Hasel

The Transmitter @thetransmitter.bsky.social · Mar 28

The cell bodies of astrocytes, not their end-feet, make up the brain’s last line of defense, a new paper in Cell Reports confirms. The findings flip the standard picture of these “stalwart sentinels” of the brain.

By Lauren Schenkman

www.thetransmitter.org/astrocytes/u...

The brain’s “stalwart sentinels” express an unexpected gene

The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

www.thetransmitter.org

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Philip Hasel @philiphasel.bsky.social · Mar 28

Great story covering our description of the superficial glia limitans!

@thetransmitter.bsky.social :

www.thetransmitter.org/astrocytes/u...

The brain’s “stalwart sentinels” express an unexpected gene

The astrocytes that cover the brain and spinal cord and protect it from intruders lack the signature star shape and have a distinct genetic marker.

www.thetransmitter.org

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Reposted by Philip Hasel

UK Glia Network @ukglia.bsky.social · Mar 27

Have you seen our website:
Built and maintained by @drmyelin.bsky.social

Check it out 👀

www.glianetwork.org.uk

Home

What is the UK Glia network? The UK Glia network has been founded by a group of scientists representing all fields of glia research. Our primary goal is to create a community for glia researchers work...

www.glianetwork.org.uk

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Philip Hasel @philiphasel.bsky.social · Mar 23

Highly recommend Aida and her lab! Apply for this amazing opportunity:

Aida Rodrigo @aidarodrigo.bsky.social · Mar 23

🚨 Heads-up: a little over a week to apply for this exciting postdoc opportunity in Edinburgh @edinuni-irr.bsky.social! 🚨

I will be in Liverpool for #biologists100. Happy to chat about the position, our research, setting up a lab, spiny mice, axolotls, and whatnot!

Aida Rodrigo @aidarodrigo.bsky.social · Mar 5

📢 We are hiring! 📢

We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.

More info and how to apply: tinyurl.com/4m6yzbef

Get in touch if interested!

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Reposted by Philip Hasel

Carmen Falcone @carmenfalcone.bsky.social · Mar 18

🚨The first #preprint of the #FalconeLab is OUT!🥹🚨

We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.

Read more here, feedback is welcome!!

More details👇👇
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www.biorxiv.org/content/10.1...

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology

Glial cells are fundamental for the pathophysiology of all neurological disorders. Astrocytes, the primary homeostatic cells of the central nervous system (CNS), exhibit species-specific characteristi...

www.biorxiv.org

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Reposted by Philip Hasel

UK Glia Network @ukglia.bsky.social · Mar 12

Sometimes you have to travel to find the cutting edge of glial biology... This meeting would definitely be worth the trip 👀

www.keystonesymposia.org/conferences/...

Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology | Keystone Symposia

Join us at the Keystone Symposia on Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology, June 2025, in Whistler, with field leaders!

www.keystonesymposia.org

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Reposted by Philip Hasel

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Mar 11

Multiregional blood-brain barrier phenotyping identifies the prefrontal cortex as the most vulnerable region to ageing in mice https://www.biorxiv.org/content/10.1101/2025.03.09.642233v1

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Reposted by Philip Hasel

Melissa Cooper, PhD @melcooperphd.bsky.social · Mar 10

Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...

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