The proposal has the potential to transform the government’s vast research funding operation, which has long awarded university grants based on scientific merit.

Nature - Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.

Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Nature Communications - Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial...

Highlighted Article: MatriCom is a web application devised to mine single-cell RNA-sequencing datasets to infer extracellular matrix (ECM)–ECM and cell–ECM communication systems across cell population...

The Things We’ll Never Know: A Science Fair of Canceled Grants.