New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut to the brain, with the hel

Microglia adopt diverse states throughout life. Whether these represent fixed lineages or reversible plasticity remains unclear. Hamagami and Kapadia et al. show that reactive microglia switch states through reprogramming of histone modifications at state-specific enhancers and associated transcription factors, linking developmental, aging, and disease phenotypes within a unified dynamic framework.

Skull marrow communicates with the meninges through bone channels, yet their formation and regulation remain poorly understood. Eme-Scolan et al. show that these channels undergo active remodeling during the neonatal period and can be reshaped by modulating osteoclast activity. Channel remodeling affects immune-cell trafficking to brain borders, offering a potential strategy to tune meningeal immunity during inflammation.