Leon Smyth
@leonsmyth.bsky.social
CNS immunology, stroma, and barriers | Group Leader @Monash | former postdoc in @kipnislab @WUSTL | Kiwi 🥝 🇳🇿
Reposted by Leon Smyth
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
November 24, 2025 at 4:13 PM
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Reposted by Leon Smyth
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 24, 2025 at 4:20 PM
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
A great consensus review on brain washing from the groups doing some of the most important work in the field summarizing areas of agreement and open questions.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Resolving the mysteries of brain clearance and immune surveillance
This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing
CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems,
and neuroimmune interacti...
cell.com
November 24, 2025 at 10:10 PM
A great consensus review on brain washing from the groups doing some of the most important work in the field summarizing areas of agreement and open questions.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Leon Smyth
Wonderful to see our work so clearly and professionally presented at #AIC2025 by co–first author and graduate student Kevin Telfer.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 22, 2025 at 10:37 PM
Wonderful to see our work so clearly and professionally presented at #AIC2025 by co–first author and graduate student Kevin Telfer.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Leon Smyth
Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 8:01 PM
Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
Reposted by Leon Smyth
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 1:23 PM
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Reposted by Leon Smyth
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
PDGFRα is required for postnatal cerebral perivascular fibroblast development
Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…
www.sciencedirect.com
November 20, 2025 at 3:30 AM
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
Reposted by Leon Smyth
What are the fastest-growing areas in neuroscience? Survey respondents pointed to computational neuroscience, systems neuroscience, neuroimmunology and neuroimaging, among other subfields.
www.thetransmitter.org/neuroscience...
#neuroskyence #StateOfNeuroscience
www.thetransmitter.org/neuroscience...
#neuroskyence #StateOfNeuroscience
Survey: What are the fastest-growing areas in neuroscience?
Respondents pointed to computational neuroscience, systems neuroscience, neuroimmunology and neuroimaging, among other subfields.
www.thetransmitter.org
November 18, 2025 at 8:24 PM
What are the fastest-growing areas in neuroscience? Survey respondents pointed to computational neuroscience, systems neuroscience, neuroimmunology and neuroimaging, among other subfields.
www.thetransmitter.org/neuroscience...
#neuroskyence #StateOfNeuroscience
www.thetransmitter.org/neuroscience...
#neuroskyence #StateOfNeuroscience
Reposted by Leon Smyth
Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."
lnkd.in/gN7z6th4
lnkd.in/gN7z6th4
November 18, 2025 at 2:42 AM
Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."
lnkd.in/gN7z6th4
lnkd.in/gN7z6th4
Reposted by Leon Smyth
Australia’s first Centre of Research Excellence in #Lymphoedema and Lymphatic Regeneration has launched, led by Prof @benjhogan.bsky.social and Prof Natasha Harvey, it's been dubbed a global “paradigm shift” and a major step forward.
Read more: www.petermac.org/about-us/new...
Read more: www.petermac.org/about-us/new...
November 17, 2025 at 2:16 AM
Australia’s first Centre of Research Excellence in #Lymphoedema and Lymphatic Regeneration has launched, led by Prof @benjhogan.bsky.social and Prof Natasha Harvey, it's been dubbed a global “paradigm shift” and a major step forward.
Read more: www.petermac.org/about-us/new...
Read more: www.petermac.org/about-us/new...
Reposted by Leon Smyth
A new method uses high-resolution MRI to provide a noninvasive, granular view of cerebrospinal-fluid movement—even in the small spaces that surround blood vessels, which have not been studied before.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/cerebrospina...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/cerebrospina...
Noninvasive method lifts curtain on CSF dance in human brain
Cerebrospinal fluid shows brain-region-specific dynamics, a new high-resolution MRI approach reveals.
www.thetransmitter.org
November 14, 2025 at 6:43 PM
A new method uses high-resolution MRI to provide a noninvasive, granular view of cerebrospinal-fluid movement—even in the small spaces that surround blood vessels, which have not been studied before.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/cerebrospina...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/cerebrospina...
Reposted by Leon Smyth
Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations
@lauradata.bsky.social @ziy027.bsky.social
www.nature.com/articles/s41...
@lauradata.bsky.social @ziy027.bsky.social
www.nature.com/articles/s41...
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience
Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
www.nature.com
November 12, 2025 at 8:18 PM
Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations
@lauradata.bsky.social @ziy027.bsky.social
www.nature.com/articles/s41...
@lauradata.bsky.social @ziy027.bsky.social
www.nature.com/articles/s41...
Reposted by Leon Smyth
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
November 4, 2025 at 10:58 PM
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
Reposted by Leon Smyth
Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com
The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.
Makes me also wonder how many could be druggable targets.
The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.
Makes me also wonder how many could be druggable targets.
November 6, 2025 at 6:50 PM
Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com
The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.
Makes me also wonder how many could be druggable targets.
The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.
Makes me also wonder how many could be druggable targets.
Reposted by Leon Smyth
Lymphoid gene expression (CD28) in plaque-associated PU.1low microglia supports neuroprotective functions that mitigate the progression of Alzheimer’s disease
www.nature.com/articles/s41... @nature.com
www.nature.com/articles/s41... @nature.com
November 5, 2025 at 10:57 PM
Lymphoid gene expression (CD28) in plaque-associated PU.1low microglia supports neuroprotective functions that mitigate the progression of Alzheimer’s disease
www.nature.com/articles/s41... @nature.com
www.nature.com/articles/s41... @nature.com
Reposted by Leon Smyth
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Reposted by Leon Smyth
Excited to see the updated results from INDIGO confirming sustained benefit of mIDH inhibition for 1st line treatment in patients with G2 gliomas. Reduced seizure frequency aligns with our findings that mIDH inhibition modulates the glioma electrical microenvironment! 👇
November 3, 2025 at 2:57 AM
Excited to see the updated results from INDIGO confirming sustained benefit of mIDH inhibition for 1st line treatment in patients with G2 gliomas. Reduced seizure frequency aligns with our findings that mIDH inhibition modulates the glioma electrical microenvironment! 👇
Reposted by Leon Smyth
‼️Lymphatic Education&Research Network-GRC Scholarships‼️
LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.
🗓 Apply by Dec 8, 2025!
form.jotform.com/LERN/2026-gr...
LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.
🗓 Apply by Dec 8, 2025!
form.jotform.com/LERN/2026-gr...
October 31, 2025 at 5:11 PM
‼️Lymphatic Education&Research Network-GRC Scholarships‼️
LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.
🗓 Apply by Dec 8, 2025!
form.jotform.com/LERN/2026-gr...
LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.
🗓 Apply by Dec 8, 2025!
form.jotform.com/LERN/2026-gr...
Reposted by Leon Smyth
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
October 31, 2025 at 10:10 AM
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Leon Smyth
📣Registration is now open for the Gordon Research Seminar and Gordon Research Conference on Lymphatics 2026!
Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work!
grc.org/lymphatics-g...
grc.org/lymphatics-c...
Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work!
grc.org/lymphatics-g...
grc.org/lymphatics-c...
October 6, 2025 at 3:28 PM
📣Registration is now open for the Gordon Research Seminar and Gordon Research Conference on Lymphatics 2026!
Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work!
grc.org/lymphatics-g...
grc.org/lymphatics-c...
Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work!
grc.org/lymphatics-g...
grc.org/lymphatics-c...
Reposted by Leon Smyth
Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience
Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
www.nature.com
October 29, 2025 at 7:26 PM
Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...
Reposted by Leon Smyth
#NZ
Science in NZ has long been underfunded. Cuts to both staff and funding by the current coalition have cut into something already stretched thin.
Winner of top science prize blames ‘batshit’ Budget for brain drain
newsroom.co.nz/2025/10/29/w...
Science in NZ has long been underfunded. Cuts to both staff and funding by the current coalition have cut into something already stretched thin.
Winner of top science prize blames ‘batshit’ Budget for brain drain
newsroom.co.nz/2025/10/29/w...
Winner of top science prize blames ‘batshit’ Budget for brain drain
Dr Samuel Mehr says the Government values science, but their ‘idiotic’ approach to funding it will cost them their brightest.
newsroom.co.nz
October 29, 2025 at 8:12 AM
#NZ
Science in NZ has long been underfunded. Cuts to both staff and funding by the current coalition have cut into something already stretched thin.
Winner of top science prize blames ‘batshit’ Budget for brain drain
newsroom.co.nz/2025/10/29/w...
Science in NZ has long been underfunded. Cuts to both staff and funding by the current coalition have cut into something already stretched thin.
Winner of top science prize blames ‘batshit’ Budget for brain drain
newsroom.co.nz/2025/10/29/w...
Reposted by Leon Smyth
"Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government."
AND the NZ government!
www.nature.com/articles/d41...
AND the NZ government!
www.nature.com/articles/d41...
October 29, 2025 at 9:14 PM
"Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government."
AND the NZ government!
www.nature.com/articles/d41...
AND the NZ government!
www.nature.com/articles/d41...
Reposted by Leon Smyth
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Leon Smyth
A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience
Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...
www.nature.com
October 24, 2025 at 4:02 PM
A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels
www.nature.com/articles/s41...
www.nature.com/articles/s41...