Pranvera Sadiku
@pranvera.bsky.social
Postdoc in @walmsley-lab.bsky.social @edinuni-irr.bsky.social interested in neutrophils and metabolism.
Reposted by Pranvera Sadiku
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
December 15, 2025 at 8:09 PM
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Reposted by Pranvera Sadiku
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.23.666094v1
July 27, 2025 at 10:16 AM
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.23.666094v1
Reposted by Pranvera Sadiku
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 11:28 AM
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pranvera Sadiku
Did you ever wonder why metastatic cancers often spread to the lungs? Amazing research from @ginevradoglioni.bsky.social! Many thanks to all collaborators, funders and patients. Wishing you all an enjoyable read and a happy new year and Ginevra a great next endeavor @salkinstitute.bsky.social
Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
go.nature.com
January 1, 2025 at 5:16 PM
Did you ever wonder why metastatic cancers often spread to the lungs? Amazing research from @ginevradoglioni.bsky.social! Many thanks to all collaborators, funders and patients. Wishing you all an enjoyable read and a happy new year and Ginevra a great next endeavor @salkinstitute.bsky.social
Reposted by Pranvera Sadiku
#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...
www.nature.com
January 8, 2025 at 3:48 PM
#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance