noam
@prywes.bsky.social
Rubisco, protein engineering and photosynthesis at the Cambridge Biochemistry Department.
pryweslab.org
pryweslab.org
New carboxylases (and new pathway reactions) expand the possibilities for alternative carbon fixation cycles. Amazing work from the Claassens lab!! (Vittorio in particular, this is a huge body of work).
This changes my assumptions around what can be expected from future new cycles. ♻️
This changes my assumptions around what can be expected from future new cycles. ♻️
Newest preprint from our lab: a new family of promising synthetic CO2 fixation cycles that may outcompete the Calvin cycle and that Vittorio Rainaldi realized to a great extent in E. coli! Up to 11 heterologous enzymes in a cascade supporting CO2 fixation & growth! www.biorxiv.org/content/10.1...
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation
Biological carbon fixation is currently limited to seven naturally occurring pathways. Synthetic carbon fixation pathways have the potential to surpass aerobic natural pathways in efficiency, but none...
www.biorxiv.org
November 26, 2025 at 7:14 AM
New carboxylases (and new pathway reactions) expand the possibilities for alternative carbon fixation cycles. Amazing work from the Claassens lab!! (Vittorio in particular, this is a huge body of work).
This changes my assumptions around what can be expected from future new cycles. ♻️
This changes my assumptions around what can be expected from future new cycles. ♻️
🔥
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
www.science.org
November 23, 2025 at 11:23 PM
🔥
Reposted by noam
Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The virulence gene ToxB is both amplified and disrupted by transposons in the wheat pathogen Pyrenophora tritici-repentis
### Competing Interest Statement
The authors have declared no competing interest.
Agriculture and Agri-Food Canada, https://ror.org/051dzs374
Alberta Grain
Saskatchewan Wheat Development Commissio...
www.biorxiv.org
November 18, 2025 at 4:22 PM
Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by noam
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 13, 2025 at 10:15 PM
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Reposted by noam
We are delighted that our Alkis Seraphim Memorial Lecturer for 2025 is Prof Ben Lehner speaking on 'Mapping the energetic and allosteric structures of proteins at scale' on 4 December at 4.30pm in the Babbage Lecture Theatre. Further details and book here: www.eventbrite.com/e/alkis-sera...
November 10, 2025 at 12:57 PM
We are delighted that our Alkis Seraphim Memorial Lecturer for 2025 is Prof Ben Lehner speaking on 'Mapping the energetic and allosteric structures of proteins at scale' on 4 December at 4.30pm in the Babbage Lecture Theatre. Further details and book here: www.eventbrite.com/e/alkis-sera...
Reposted by noam
excited to see this one with @leahtaylorkearney.bsky.social @prywes.bsky.social et al. out, bringing a truly interdisciplinary (comparative genomics/phylogeny + biochemistry) lens to our favorite enzyme rubisco
Diversity-driven biochemical survey reveals dimeric structural origin of rubisco https://www.biorxiv.org/content/10.1101/2025.11.05.686826v1
November 7, 2025 at 8:05 PM
excited to see this one with @leahtaylorkearney.bsky.social @prywes.bsky.social et al. out, bringing a truly interdisciplinary (comparative genomics/phylogeny + biochemistry) lens to our favorite enzyme rubisco
Reposted by noam
🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
Redirecting
doi.org
October 24, 2025 at 5:00 PM
🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
Reposted by noam
Here are some “leaf” or phyllid cells from moss Physcomitrium patens gametophore. Cells are expressing a green fluorescence marker that labels the vacuolar membrane. Chloroplasts' autofluorescence is in magenta.
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells
October 13, 2025 at 2:40 PM
Here are some “leaf” or phyllid cells from moss Physcomitrium patens gametophore. Cells are expressing a green fluorescence marker that labels the vacuolar membrane. Chloroplasts' autofluorescence is in magenta.
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells
Reposted by noam
Applications are open for a fully funded PhD studentship: "Matchmaker: Prioritising the best cell line for expressing target proteins using CRISPR and machine learning" at @cambiochem.bsky.social and AZ.
⏳ Closing date: 31 October 2025
📆 Start date: 1 October 2026
🔗 www.cam.ac.uk/jobs/astraze...
⏳ Closing date: 31 October 2025
📆 Start date: 1 October 2026
🔗 www.cam.ac.uk/jobs/astraze...
October 11, 2025 at 12:27 PM
Applications are open for a fully funded PhD studentship: "Matchmaker: Prioritising the best cell line for expressing target proteins using CRISPR and machine learning" at @cambiochem.bsky.social and AZ.
⏳ Closing date: 31 October 2025
📆 Start date: 1 October 2026
🔗 www.cam.ac.uk/jobs/astraze...
⏳ Closing date: 31 October 2025
📆 Start date: 1 October 2026
🔗 www.cam.ac.uk/jobs/astraze...
Reposted by noam
Another #PhD project available for applications in #photosynthesis with @ecarmosilva.bsky.social @sci-tech-lancaster.bsky.social looking at ways to improve Rubisco. Details below including how the successful nominee will play a direct role in shaping the project proposal tinyurl.com/2a8szv3y
Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation on FindAPhD.com
PhD Project - Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation, listed on FindAPhD.com
tinyurl.com
October 2, 2025 at 5:06 PM
Another #PhD project available for applications in #photosynthesis with @ecarmosilva.bsky.social @sci-tech-lancaster.bsky.social looking at ways to improve Rubisco. Details below including how the successful nominee will play a direct role in shaping the project proposal tinyurl.com/2a8szv3y
Reposted by noam
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 1, 2025 at 5:57 PM
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Reposted by noam
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by noam
New Paper Alert! “The diversity of PET-degrading enzymes: A review”. We present a database of PET-plastic hydrolases, including sequence, structure, and function. From this, we discuss the distribution, efficiency, stability, and potential for biodegradation of PETases.
September 14, 2025 at 6:59 AM
New Paper Alert! “The diversity of PET-degrading enzymes: A review”. We present a database of PET-plastic hydrolases, including sequence, structure, and function. From this, we discuss the distribution, efficiency, stability, and potential for biodegradation of PETases.
Reposted by noam
I am thrilled to announce that I just opened my lab at New York University in @nyucns.bsky.social and Biology! Our work will explore the richness of animal behavior, dissecting the genetic and circuit mechanisms that shape its evolution.
September 4, 2025 at 5:13 PM
I am thrilled to announce that I just opened my lab at New York University in @nyucns.bsky.social and Biology! Our work will explore the richness of animal behavior, dissecting the genetic and circuit mechanisms that shape its evolution.
Reposted by noam
We are hiring! The #PlantBio department at UIUC is looking to recruit an Assistant Professor in Plant-Fungal interactions. Application deadline is October 31st @dallingjim.bsky.social see the link below for more details:
illinois.csod.com/ux/ats/caree...
illinois.csod.com/ux/ats/caree...
Assistant Professor- Department of Plant Biology
Duties & Responsibilities
illinois.csod.com
September 4, 2025 at 1:48 PM
We are hiring! The #PlantBio department at UIUC is looking to recruit an Assistant Professor in Plant-Fungal interactions. Application deadline is October 31st @dallingjim.bsky.social see the link below for more details:
illinois.csod.com/ux/ats/caree...
illinois.csod.com/ux/ats/caree...
Reposted by noam
Applications are invited for our Independent Research Fellowship scheme to support early career scientists in establishing their own research groups. The deadline is 24 October 2025 and further details of how to apply are here: www.bioc.cam.ac.uk/research/ind...
September 3, 2025 at 9:41 AM
Applications are invited for our Independent Research Fellowship scheme to support early career scientists in establishing their own research groups. The deadline is 24 October 2025 and further details of how to apply are here: www.bioc.cam.ac.uk/research/ind...
Reposted by noam
Professor Susanne von Caemmerer FRS and Professor Graham Douglas Farquhar FRS are jointly awarded the Royal Medal (Biological) 2025 for refining the ways we monitor and model photosynthesis in leaves from molecular to global scales. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/
August 28, 2025 at 10:30 AM
Professor Susanne von Caemmerer FRS and Professor Graham Douglas Farquhar FRS are jointly awarded the Royal Medal (Biological) 2025 for refining the ways we monitor and model photosynthesis in leaves from molecular to global scales. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/
Reposted by noam
Excited to share our new preprint co-led by @jnoms.bsky.social!
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...
www.biorxiv.org
August 22, 2025 at 7:02 PM
Excited to share our new preprint co-led by @jnoms.bsky.social!
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
!!! Yes!
Incredibly honored to receive support from the Hypothesis Fund!
🤩 New awards announcement! ✨ We're excited to announce our latest awardees who are tackling bold research that spans immunology, plant biology, and genetics. Learn more about these talented scientists below!
Discover our full portfolio: bit.ly/HFAwardees 1/
Discover our full portfolio: bit.ly/HFAwardees 1/
August 20, 2025 at 5:18 AM
!!! Yes!
Reposted by noam
I love this diagram
August 18, 2025 at 1:29 PM
I love this diagram
Reposted by noam
The first paper from my PhD is out now! doi.org/10.1111/jeu....
We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia 🇨🇦
Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social
#protistsonsky
We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia 🇨🇦
Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social
#protistsonsky
August 18, 2025 at 11:36 AM
The first paper from my PhD is out now! doi.org/10.1111/jeu....
We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia 🇨🇦
Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social
#protistsonsky
We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia 🇨🇦
Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social
#protistsonsky
Reposted by noam
You can't let those macroeconomic headwinds tell you how to live your life
August 15, 2025 at 9:03 PM
You can't let those macroeconomic headwinds tell you how to live your life
Reposted by noam
🚨 We’re hiring! The Burlacot Lab @carnegiescience.bsky.social is recruiting a Postdoc to study how photosynthetic electron flows power CO₂ fixation in algae 🌱🧫
Cutting-edge microscopy + biophysics + sustainability 🚀
Apply: apply.interfolio.com/171656
Cutting-edge microscopy + biophysics + sustainability 🚀
Apply: apply.interfolio.com/171656
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
August 10, 2025 at 9:36 PM
🚨 We’re hiring! The Burlacot Lab @carnegiescience.bsky.social is recruiting a Postdoc to study how photosynthetic electron flows power CO₂ fixation in algae 🌱🧫
Cutting-edge microscopy + biophysics + sustainability 🚀
Apply: apply.interfolio.com/171656
Cutting-edge microscopy + biophysics + sustainability 🚀
Apply: apply.interfolio.com/171656
Reposted by noam
Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...
Postdoctoral Fellow, Hattie Chung Lab (Yale School of Medicine)
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
August 8, 2025 at 6:06 PM
Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...