Babak Razani, MD, PhD Laboratory
@razanilab.bsky.social
The Razani lab (www.razani.org) @ Center for Immunometabolism (cim.pitt.edu) and Vascular Medicine Institute (vmi.pitt.edu), University of Pittsburgh studies macrophages, autophagy-lysosomes, & nutrient sensing/signaling in metabolic disease
Pinned
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
jci.org/articles/view/185340
Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help.
www.frontiersin.org/journals/nut...
www.frontiersin.org/journals/nut...
Frontiers | Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction
Trehalose is a naturally occurring disaccharide with versatile commercial applications and health benefits, including promise as a therapeutic for obesity an...
www.frontiersin.org
June 25, 2025 at 5:19 PM
Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help.
www.frontiersin.org/journals/nut...
www.frontiersin.org/journals/nut...
Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!
April 26, 2025 at 6:48 PM
Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!
Reposted by Babak Razani, MD, PhD Laboratory
Spilling the skinny on fat cells!
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
March 31, 2025 at 1:20 PM
Spilling the skinny on fat cells!
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
Reposted by Babak Razani, MD, PhD Laboratory
Spilling the skinny on fat cells!
ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
March 28, 2025 at 5:38 PM
Spilling the skinny on fat cells!
ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression
Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo
et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L
axis controllin...
www.cell.com
March 26, 2025 at 7:43 PM
Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
jci.org/articles/view/185340
March 19, 2025 at 1:41 PM
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
jci.org/articles/view/185340
Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩
March 14, 2025 at 6:29 PM
Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩
Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪
www.unitedformedicalresearch.org/annual-econo...
www.unitedformedicalresearch.org/annual-econo...
www.unitedformedicalresearch.org
March 12, 2025 at 3:43 AM
Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪
www.unitedformedicalresearch.org/annual-econo...
www.unitedformedicalresearch.org/annual-econo...
Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
February 27, 2025 at 8:45 PM
Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target - Nature Aging
Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse mod...
www.nature.com
February 19, 2025 at 4:56 AM
Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!
February 17, 2025 at 11:41 PM
Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!