Gregory Riely
@rielymd.bsky.social
Medical Oncologist in NYC. Ning Zhao and Ge Li Endowed Chair. Lung and thymic cancer. COI: https://coi.asco.org/share/EXW-L4KS/Gregory%20Riely
Reposted by Gregory Riely
“You are taking the decision away from the reviewers, and you’re putting it in the hands of the political leaders of FDA,” Fernandez Lynch said.
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
FDA review staff was excluded from voting on whether to approve first priority voucher drug
Top officials like Vinay Prasad and George Tidmarsh voted on the drug, a major break from the FDA's typical practice.
www.statnews.com
November 24, 2025 at 4:31 PM
“You are taking the decision away from the reviewers, and you’re putting it in the hands of the political leaders of FDA,” Fernandez Lynch said.
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
Reposted by Gregory Riely
The number of ways this is disgraceful behavior from the Secretary of Defense is...a lot.
Service members do have a duty to refuse illegal orders
All Americans have a 1st Amendment right to say that out loud.
Service members do have a duty to refuse illegal orders
All Americans have a 1st Amendment right to say that out loud.
Hegseth is now threatening to recall Sen. Mark Kelly to active duty in order to court martial him.
November 24, 2025 at 5:29 PM
The number of ways this is disgraceful behavior from the Secretary of Defense is...a lot.
Service members do have a duty to refuse illegal orders
All Americans have a 1st Amendment right to say that out loud.
Service members do have a duty to refuse illegal orders
All Americans have a 1st Amendment right to say that out loud.
Reposted by Gregory Riely
Translation from Swedish to English
Director Bhattacharya: As a scientist, when you see negative excess deaths starting during a serious disease outbreak, does that cause you to question the assumptions of your model?
Director Bhattacharya: As a scientist, when you see negative excess deaths starting during a serious disease outbreak, does that cause you to question the assumptions of your model?
November 24, 2025 at 1:39 PM
Translation from Swedish to English
Director Bhattacharya: As a scientist, when you see negative excess deaths starting during a serious disease outbreak, does that cause you to question the assumptions of your model?
Director Bhattacharya: As a scientist, when you see negative excess deaths starting during a serious disease outbreak, does that cause you to question the assumptions of your model?
Reposted by Gregory Riely
We are looking for a new Chair of our Department of Imaging. Please RP! www.nejmcareercenter.org/job/940419/c... #imaging #radiology
Chair of the Department of Imaging - Los Angeles, California job with Cedars Sinai Medical Center | 940419
Cedars-Sinai Health System seeks a collaborative and strategic leader to serve as chair of the Department of Imaging
www.nejmcareercenter.org
November 23, 2025 at 9:14 PM
We are looking for a new Chair of our Department of Imaging. Please RP! www.nejmcareercenter.org/job/940419/c... #imaging #radiology
Discussion of FDAs new super-rapid review process and criteria to get such rapid reviews. www.statnews.com/2025/11/21/f... via @statnews.com
The Trump administration is turning drug review into make-a-deal
“FDA decision-making may be reduced to a sequence of ‘make-a-deals’ with Trump, his FDA, or even political allies,” experts warn.
www.statnews.com
November 21, 2025 at 1:08 PM
Discussion of FDAs new super-rapid review process and criteria to get such rapid reviews. www.statnews.com/2025/11/21/f... via @statnews.com
Editorial in @jama.com : jamanetwork.com/journals/jam... @sequistud.bsky.social
Letter with data: jamanetwork.com/journals/jam...
Letter with data: jamanetwork.com/journals/jam...
November 20, 2025 at 2:04 PM
Editorial in @jama.com : jamanetwork.com/journals/jam... @sequistud.bsky.social
Letter with data: jamanetwork.com/journals/jam...
Letter with data: jamanetwork.com/journals/jam...
Reposted by Gregory Riely
Trump has murdered at least 83 people with extrajudicial military strikes on alleged drug-trafficking boats.
He needs to face consequences for this.
His secretary of DHHS, RFK Jr., will kill several orders of magnitude more with this disinformation.
He needs to face consequences for this.
His secretary of DHHS, RFK Jr., will kill several orders of magnitude more with this disinformation.
This is completely disgusting. Today, the CDC updated their vaccine safety page. It now says:
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
November 20, 2025 at 5:31 AM
Trump has murdered at least 83 people with extrajudicial military strikes on alleged drug-trafficking boats.
He needs to face consequences for this.
His secretary of DHHS, RFK Jr., will kill several orders of magnitude more with this disinformation.
He needs to face consequences for this.
His secretary of DHHS, RFK Jr., will kill several orders of magnitude more with this disinformation.
Reposted by Gregory Riely
In this season of performance evaluations, let’s keep the focus and the feedback flowing to those who are there to receive it...and not bask in the glory of one’s own reflections.
#leadership #worklife
#leadership #worklife
November 20, 2025 at 10:29 AM
In this season of performance evaluations, let’s keep the focus and the feedback flowing to those who are there to receive it...and not bask in the glory of one’s own reflections.
#leadership #worklife
#leadership #worklife
Reposted by Gregory Riely
The official CDC website on autism and vaccines is now a screed of cherry-picked data and conspiratorial thinking claiming that actually vaccines *might* cause autism.
This is where we’re at folks…
🧪
This is where we’re at folks…
🧪
November 20, 2025 at 11:54 AM
The official CDC website on autism and vaccines is now a screed of cherry-picked data and conspiratorial thinking claiming that actually vaccines *might* cause autism.
This is where we’re at folks…
🧪
This is where we’re at folks…
🧪
Nice to see online from
@kcarbourmd.bsky.social @jessieross.bsky.social
and colleagues. Shows overlap of MTAP del and EGFR mut at baseline and resistance. Evidence of potential treatment option
www.jto.org/article/S155...
@mskcancercenter.bsky.social @iaslc.bsky.social @jtoonline.bsky.social
@kcarbourmd.bsky.social @jessieross.bsky.social
and colleagues. Shows overlap of MTAP del and EGFR mut at baseline and resistance. Evidence of potential treatment option
www.jto.org/article/S155...
@mskcancercenter.bsky.social @iaslc.bsky.social @jtoonline.bsky.social
November 17, 2025 at 9:08 PM
Nice to see online from
@kcarbourmd.bsky.social @jessieross.bsky.social
and colleagues. Shows overlap of MTAP del and EGFR mut at baseline and resistance. Evidence of potential treatment option
www.jto.org/article/S155...
@mskcancercenter.bsky.social @iaslc.bsky.social @jtoonline.bsky.social
@kcarbourmd.bsky.social @jessieross.bsky.social
and colleagues. Shows overlap of MTAP del and EGFR mut at baseline and resistance. Evidence of potential treatment option
www.jto.org/article/S155...
@mskcancercenter.bsky.social @iaslc.bsky.social @jtoonline.bsky.social
At New York Lung, Charlie Rudin @mskdeptofmed.bsky.social showing trials and investigators representing future approaches in small cell lung cancer @jessieross.bsky.social
November 15, 2025 at 3:51 PM
At New York Lung, Charlie Rudin @mskdeptofmed.bsky.social showing trials and investigators representing future approaches in small cell lung cancer @jessieross.bsky.social
Reposted by Gregory Riely
More mechanisms of resistance to anti-HER2 ADCs, this time with a focus on loss of target interaction!
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance mech...
aacrjournals.org
November 10, 2025 at 7:10 PM
More mechanisms of resistance to anti-HER2 ADCs, this time with a focus on loss of target interaction!
Reposted by Gregory Riely
ADC resistance is likely heterogeneous, and the phenomena above may explain only a portion of cases. But these early clues can inform prospective trail efforts, as well as ADC sequencing strategies. There is much more to come!
November 10, 2025 at 4:55 PM
ADC resistance is likely heterogeneous, and the phenomena above may explain only a portion of cases. But these early clues can inform prospective trail efforts, as well as ADC sequencing strategies. There is much more to come!
Reposted by Gregory Riely
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance mech...
aacrjournals.org
November 10, 2025 at 4:55 PM
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Gregory Riely
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
November 10, 2025 at 6:15 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
Reposted by Gregory Riely
Interesting article out this week from Dr. Bishal Gyawali, arguing that we should use more superiority designs for treatment de-escalation studies in cancer.
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
November 7, 2025 at 10:31 PM
Interesting article out this week from Dr. Bishal Gyawali, arguing that we should use more superiority designs for treatment de-escalation studies in cancer.
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
"The burden of proof in medicine lies on more treatment."
academic.oup.com/jnci/advance...
This Congress will be in session tomorrow. Join us live or online! Great speakers with a multidisciplinary agenda. web.cvent.com/event/35cf07...
November 7, 2025 at 12:35 AM
This Congress will be in session tomorrow. Join us live or online! Great speakers with a multidisciplinary agenda. web.cvent.com/event/35cf07...
Reposted by Gregory Riely
I cancelled a full day of clinic 4 months ago for my study section meeting that was supposed to happen this week. Clearing our schedules to reschedule these cancelled grant review panels is not so easy…
November 3, 2025 at 3:47 PM
I cancelled a full day of clinic 4 months ago for my study section meeting that was supposed to happen this week. Clearing our schedules to reschedule these cancelled grant review panels is not so easy…
Reposted by Gregory Riely
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 11:36 AM
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Reposted by Gregory Riely
Clinic
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
October 30, 2025 at 11:55 AM
Clinic
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.
Reposted by Gregory Riely
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
October 30, 2025 at 10:37 AM
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
Reposted by Gregory Riely
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
October 30, 2025 at 11:10 AM
My quote of the day
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Leadership is solving problems. The day soldiers stop bringing you their problems is the day you have stopped leading them. They have either lost confidence that you can help or concluded you do not care. Either case is a failure of leadership.
Colin Powell
Reposted by Gregory Riely
October 30, 2025 at 11:33 AM