NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, and mitochondrial function remain unaffected, suggesting that NAD depletion does not drive age-related muscle decline.

Background Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanism...

DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...

A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...

Background Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular adaptation are still largely unknown. In this study, we measured subs...

Duchenne muscular dystrophy (DMD) is a progressive disease associated with functional decline. Chronic administration of cardiosphere-derived cell therapy prevents disease-related functional decline f...

Nature Reviews Molecular Cell Biology, Published online: 17 March 2025; doi:10.1038/s41580-025-00828-1Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the…

Nature Reviews Bioengineering, Published online: 17 March 2025; doi:10.1038/s44222-025-00286-6A thorough understanding of the life cycle of extracellular vesicles is essential to unleash their full potential in biomarker identification and therapeutics…

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The nuclear periphery is linked with transcriptional repression, but MyoD1 remains active during myoblast proliferation despite being in this compartment. Here, the authors show that WFS1 tethers MyoD...

Genome-wide survey of human and mouse DMD tissues suggests EZH2’s role in satellite cells; its inhibition improves prognosis.

During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−], [H+] or pH). We critically evaluate whether this causes/co...

Muscle stem cells (satellite cells) promote adult skeletal muscle adaptation. The presence of satellite cells affects the skeletal muscle methylome response to lifelong wheel running - specifically i...