@saligramalab.bsky.social
#TCR and #human diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. Studying T cells in brain doesn't make me a neuroimmunologist!
Pinned
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
November 26, 2025 at 3:47 PM
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
November 20, 2025 at 11:24 AM
Guidelines for T cell nomenclature www.nature.com/articles/s41...
Guidelines for T cell nomenclature - Nature Reviews Immunology
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...
www.nature.com
November 19, 2025 at 11:27 AM
Guidelines for T cell nomenclature www.nature.com/articles/s41...
I am #obsessed with this concept of #TCR #crossreactivity and race against #pathogens in the context of #autoimmunity
November 18, 2025 at 12:30 PM
I am #obsessed with this concept of #TCR #crossreactivity and race against #pathogens in the context of #autoimmunity
November 14, 2025 at 3:45 AM
#Today is a #better #day. I would put it as #exceptional as I have avoided the #concept of publishing for the sake of publishing ( #advice given to me -publish soon, otherwise you won't get grants, or the tenure)....tremendous #thank you to our #team for #sticking with me to #resist the temptation!
November 12, 2025 at 12:18 PM
@itaiyanai.bsky.social gotta do a full on podcast on this!!!!
Deviating a bit from #TCRs -what does it mean for an #experiment to be #beautiful? "beautiful experiments exhibit a strong information asymmetry between the input from the experimenter and the output of the system under study" or “you get out more than you put in" press.asimov.com/articles/bea...
What Makes an Experiment Beautiful?
A beautiful experiment is not just a reflection of human ingenuity but also efficient science.
press.asimov.com
November 11, 2025 at 4:03 PM
@itaiyanai.bsky.social gotta do a full on podcast on this!!!!
Deviating a bit from #TCRs -what does it mean for an #experiment to be #beautiful? "beautiful experiments exhibit a strong information asymmetry between the input from the experimenter and the output of the system under study" or “you get out more than you put in" press.asimov.com/articles/bea...
What Makes an Experiment Beautiful?
A beautiful experiment is not just a reflection of human ingenuity but also efficient science.
press.asimov.com
November 11, 2025 at 3:15 PM
Deviating a bit from #TCRs -what does it mean for an #experiment to be #beautiful? "beautiful experiments exhibit a strong information asymmetry between the input from the experimenter and the output of the system under study" or “you get out more than you put in" press.asimov.com/articles/bea...
Well @governor.ca.gov it’s your folks who caved -what do you say???
Tonight’s Senate vote on the federal government shutdown should have been a time for strength.
Instead we saw capitulation and a betrayal of working Americans.
The American people need more from their leaders.
Instead we saw capitulation and a betrayal of working Americans.
The American people need more from their leaders.
November 10, 2025 at 3:55 PM
Well @governor.ca.gov it’s your folks who caved -what do you say???
Again for the lovers of #TCRs Molecular mimicry as a driver of T cell-mediated tumour immunity: Trends in Immunology www.cell.com/trends/immun...
Molecular mimicry as a driver of T cell-mediated tumour immunity
Recently, a large pool of antigens derived from viral and bacterial microorganisms
showing molecular mimicry with tumour-cell-expressed antigens was identified. These
antigens can be presented by MHC ...
www.cell.com
November 6, 2025 at 4:25 PM
Again for the lovers of #TCRs Molecular mimicry as a driver of T cell-mediated tumour immunity: Trends in Immunology www.cell.com/trends/immun...
With the technology available today -it's easy to #sequence #millions of #TCRs/T cells....time has come to in the same way to find #specificities for these #TCRs.... no reason not to do it!
November 6, 2025 at 1:44 PM
With the technology available today -it's easy to #sequence #millions of #TCRs/T cells....time has come to in the same way to find #specificities for these #TCRs.... no reason not to do it!
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocomp…
www.sciencedirect.com
November 5, 2025 at 9:16 PM
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
Tenure was supposed to protect inquiry—now it’s a status symbol!
November 2, 2025 at 7:39 PM
Tenure was supposed to protect inquiry—now it’s a status symbol!
From accepted in principle to #officially #accepted
October 30, 2025 at 11:38 PM
From accepted in principle to #officially #accepted
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR | Science www.science.org/doi/10.1126/...
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of cardiovascular disease—can raise circulating low-density lipoprotein (LDL) cholesterol concentrations and i...
www.science.org
October 30, 2025 at 9:19 PM
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR | Science www.science.org/doi/10.1126/...
Admiring the amount of work that went into this paper -https://www.science.org/doi/10.1126/science.ady7186
October 30, 2025 at 9:18 PM
Admiring the amount of work that went into this paper -https://www.science.org/doi/10.1126/science.ady7186
I am supposed to be at studysection -as it is not happening! I diverted myself #reading #nonscience, #needing some #inspiration from this #world! Read some of this “We Are the Ones We've Been Waiting For” yieldgiving.com/essays/ @mackenziescott.bsky.social
Yield Giving
Established by MacKenzie Scott to share a financial fortune created through the effort of countless people, Yield is named after a belief in adding value…
yieldgiving.com
October 30, 2025 at 9:05 PM
I am supposed to be at studysection -as it is not happening! I diverted myself #reading #nonscience, #needing some #inspiration from this #world! Read some of this “We Are the Ones We've Been Waiting For” yieldgiving.com/essays/ @mackenziescott.bsky.social
not enough #NYC you have every chance to make it more than 50%….your chance is few days away NOW GO #VOTE @zohrankmamdani.bsky.social
Two new polls today in NYC mayor race: Zohran Mamdani now at 50% to Cuomo's 25% in Emerson poll. In Marist poll, Zohran is up by 16% over Cuomo. Of People who voted early 58%, had cast their ballots for Mamdani. This has the makings of a blow out win for the working class and big loss for oligarchs
October 30, 2025 at 8:45 PM
not enough #NYC you have every chance to make it more than 50%….your chance is few days away NOW GO #VOTE @zohrankmamdani.bsky.social
Reposted
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
October 29, 2025 at 8:55 PM
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
In #conclusion!!!!, "We provide interactive tools for exploring this extensive human immune health resource at" www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
www.nature.com
October 29, 2025 at 4:50 PM
In #conclusion!!!!, "We provide interactive tools for exploring this extensive human immune health resource at" www.nature.com/articles/s41...
I hope #government #opens miraculously in two days...I have read some #amazing #grants and #investigators who applied, put great effort in submitting these #grants
October 28, 2025 at 5:43 PM
I hope #government #opens miraculously in two days...I have read some #amazing #grants and #investigators who applied, put great effort in submitting these #grants
" #Application has been #entered into the #computer, #ID #not #yet #assigned" -This is the #status of #recently #submitted #NIH #grant in #eRA...let see how long this lasts!!!
October 27, 2025 at 5:13 PM
" #Application has been #entered into the #computer, #ID #not #yet #assigned" -This is the #status of #recently #submitted #NIH #grant in #eRA...let see how long this lasts!!!
As like in other sectors #oligarchy wins and will #sustain its presence during this #funding #cuts - #NewPIs, #ESIs and #next #generation of #young #scientists #suffer the #most -an unpopular opinion @jeremymberg.bsky.social
October 23, 2025 at 1:35 PM
As like in other sectors #oligarchy wins and will #sustain its presence during this #funding #cuts - #NewPIs, #ESIs and #next #generation of #young #scientists #suffer the #most -an unpopular opinion @jeremymberg.bsky.social
