Santi Letona
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santiletona.bsky.social
Santi Letona
@santiletona.bsky.social
☕️Science-ing things up 🧠
🧫Infectious Disease🦠Sepsis and inmune system 📚 PhD student 🧬
Zaragoza. Spain.
Reposted by Santi Letona
🗳️Raffle time! Epipocalypse: Bug Detectives is halfway thru its Kickstarter.📢

Will give away 1 copy to the school, hospital, or club of choice to 2 raffle winners. Raffle ends Sunday AM. Every RT is an entry. Spread the good news!

#IDSky #MedSky #EpiSky

www.kickstarter.com/projects/pha...
October 16, 2025 at 4:47 PM
Reposted by Santi Letona
How to safely use LLM (like ChatGPT) in your daily work, by @joserrapa.bsky.social.
Fantastic talk on AI use for antibiotic stewardship in #ESCMIDGlobal!
#AMSky
April 14, 2025 at 1:44 PM
Reposted by Santi Letona
April 13, 2025 at 3:15 PM
Huge thanks to @esgap.bsky.social for the travel grant that allowed me to attend @escmid.bsky.social #ESCMIDGlobal and present my poster this Saturday. Grateful for the chance to share our work and connect with the amazing ID community!
April 13, 2025 at 2:38 PM
Reposted by Santi Letona
Periodic reminder the world of data analysis cannot be meaningfully categorised into "machine learning" and "statistics". Two cultures with substantial overlap in the use of methods (e.g. logistic regression), analytical goals (e.g. causal inference) and history

jamanetwork.com/journals/jam...
February 4, 2025 at 8:59 AM
🥳🥳🥳
Sensible y Resistente, el podcast de @SEIMC_, comienza su andadura en @Spotify y continuamos en #CampusSEIMC. En este primer episodio hemos querido hablar con el Dr. José Molina @josemolinagb.bsky.social sobre la duración de los tratamientos antibióticos en infecciones complicadas.
February 1, 2025 at 6:54 PM
Reposted by Santi Letona
¡Sois mu grandes!
Gracias a @micromunidad.bsky.social y @listeriacolectiva.bsky.social por empujarnos a estas locuras tan geniales 🤪🥰
#AMSsky

🎙️ open.spotify.com/episode/4yak...
February 1, 2025 at 6:44 PM
Reposted by Santi Letona
🔥🔥 NEW 🔥🔥
Year In Review: Top Infectious Diseases Articles From 2024
Our new post, a great collaboration with my friend
🌟 @idstewardship.bsky.social
1️⃣6️⃣⚡️🆔 RCTs
7️⃣Syst Reviews/Meta
3️⃣🌏Guidelines ✨️Wiki_Guidelines
#idsky #EMIMCC #medsky #utisky
EnJoy
Share plz!
www.idstewardship.com/year-review-...
Year In Review: Top Infectious Diseases Articles From 2024
In this article a selection of notable peer-reviewed publications from 2024 are provided. Article Selection by: Bassam Ghanem, Pharm.D., MS, BCPS Article Construction by: Timothy P. Gauthier, Pharm.D....
www.idstewardship.com
December 11, 2024 at 11:47 PM
Reposted by Santi Letona
In hospitalized adults with sepsis, daily PCT-guided protocol reduced antibiotic duration safely compared with standard care, but daily CRP-guided protocol does not #idsky #medsky #AMSsky #EMIMCC
🔥The ADAPT-Sepsis RCT🔥
Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care.
No difference was found in total Abx duration between standard care & daily CRP-guided protocol
CRP failure #idsky #EMIMCC
jamanetwork.com/journals/jam...
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...
jamanetwork.com
December 10, 2024 at 3:51 AM
Reposted by Santi Letona
A liver transplant recipient developed ST361 NDM-5-producing E. coli bacteraemia with ATM/AVI & FDC resistance
High-level resistance was selected after CZA/ATM therapy & was mediated by baseline PBP3 mutations
New PBP3 & CMY-145 mutations emerged during therapy
https://doi.org/10.1093/jacamr/dlae141
doi.org
December 9, 2024 at 3:30 PM
Reposted by Santi Letona
Conventional intermittent dosing remains the current standard of care for beta-lactam antibiotics
🆕🔥 Editorial with ✨Prof.Jason Roberts
Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings? #idsky #medsky
onlinelibrary.wiley.com/doi/10.1111/...
November 27, 2024 at 11:46 AM
Reposted by Santi Letona
El capítulo más aterrador de Sensible y Resistente ya está aquí! 💀
Historias de terror y mitos en enfermedades infecciosas con el gran @jdelpoleo y @micromunidad.bsky.social ¿Te atreves a escucharlo?

#IDSky #AMSSky
Disponible
👇

campus.seimc.org/cursos/detal...
November 22, 2024 at 3:14 PM
Reposted by Santi Letona
What happens to the #genome of #bacteria as their association with the host becomes ever more intimate?🧪🦠

A lot: Expansion, pseudogenization and shrinkage, driven by reduction of phage pressure

New by Stefanos Siozios, Greg Hurst &co
#evolution #genomics #microbiology

www.cell.com/current-biol...
November 15, 2024 at 5:08 PM
Reposted by Santi Letona
New exciting findings on E. coli cell division: Using high throughput imaging 🔬 & stochastic modeling, we show that FtsZ—not FtsN—drives constriction at fast growth rates. Great collaboration with @arielamir.bsky.social and @KarPrathitha
www.nature.com/articles/s41...

#Microbiology #CellBiology
Determining the rate-limiting processes for cell division in Escherichia coli - Nature Communications
The recruitment of protein FtsN to midcell is thought to be the main rate-liming process for cell division in the bacterial model E. coli. Here, Männik et al. use experiments with live bacteria as wel...
www.nature.com
November 17, 2024 at 4:59 PM
Reposted by Santi Letona
Adaptation to Space Conditions of Novel Bacterial Species Isolated from the International Space Station Revealed by Functional Gene Annotations and Comparative Genome Analysis astrobiology.com/2024/09/adap... #astrobiology #genomics #ISS #microbiology #microgravity
Adaptation to Space Conditions of Novel Bacterial Species Isolated from the International Space Station Revealed by Functional Gene Annotations and Comparative Genome Analysis - Astrobiology
The extreme environment of the International Space Station (ISS) puts selective pressure on microorganisms unintentionally introduced during its 20+ years of service
astrobiology.com
November 16, 2024 at 8:12 PM