Reported herein is a total synthesis of the peptide-polyketide natural product dahurelmusin A along with its C10 epimer (epi-dahurelmusin A). The syntheses benefited from well-established aldol and macrocyclization technologies. Access to the natural product and its C10 epimer provided opportunities to test the importance of the C10 stereocenter in the biological activity of the natural product.

Since the beginning of time, humanity has searched for drugs that can relieve pain without sparking addiction or the other devastating problems tied to opioids. It’s still very early, but a UC Berkele...

By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory depression in mice

Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and ...

Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll fundamentally change how molecules are made

Herein, we report an investigation of several synthetic strategies to access the aphidicolin family of natural products. Some unsuccessful approaches include strategies featuring Diels–Alder cycloaddi...

The molecule, coined “carbamorphine,”was built through total synthesis.

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ConspectusSingle-atom skeletal editing strategies that precisely modify the core frameworks of molecules have the potential to streamline and accelerate organic synthesis by enabling conceptually simp...

Late-stage functional group switching in dibenzofurans will aid drug discovery chemistry

Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple peripheral positions are therefore highly valuable. In this ...

Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple periphe...

The new members from Berkeley have spent decades researching gene editing, materials science, very young children, the depths of the universe and more.

WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...

Heteroaromatics are the basis for many pharmaceuticals. The ability to modify these structures through selective core-atom transformations, or “skeletal edits”, can dramatically expand the landscape f...