Shivani Dharmadhikari
@sdharmadhikari.bsky.social
Curious about science! PhD student with @maitrejl at @institut_curie Paris, Prev.. UG student researcher at LeptinLab @EMBL
Current: Studying membrane mechanics in preimplantation mammalian development aka “pulling membrane tubes from mouse embryos”
Current: Studying membrane mechanics in preimplantation mammalian development aka “pulling membrane tubes from mouse embryos”
Pinned
Now What?
John J. Hopfield, Princeton University, Princeton, NJ 08544, USA. October 2018 John J. Hopfield Now What? (Article in PDF format) My first full-time permanent employment was at the Bell Telephone Labo...
pni.princeton.edu
An interesting read! An article from John Hopfield on how he chooses to work on the next question(now what?)… a question, as a scientist we often ask ourselves!
pni.princeton.edu/people/john-...
A fun way to recover embryos on a grey Parisian day 🌧️🐭
November 13, 2025 at 1:38 PM
A fun way to recover embryos on a grey Parisian day 🌧️🐭
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
August 7, 2025 at 1:38 PM
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
Reposted by Shivani Dharmadhikari
I'll kick off my bsky profile with a great 3D fluorescence microscopy time-lapse. My buddies Joe Brzostowski and Rachel Stadler (NIH) acquired this on their #snoutscope that I helped them build.
Shown is a fluorescent actin marker in Dictyostelium. Joe and Rachel called this "The Mark of Zorro!"
Shown is a fluorescent actin marker in Dictyostelium. Joe and Rachel called this "The Mark of Zorro!"
February 4, 2025 at 3:26 AM
I'll kick off my bsky profile with a great 3D fluorescence microscopy time-lapse. My buddies Joe Brzostowski and Rachel Stadler (NIH) acquired this on their #snoutscope that I helped them build.
Shown is a fluorescent actin marker in Dictyostelium. Joe and Rachel called this "The Mark of Zorro!"
Shown is a fluorescent actin marker in Dictyostelium. Joe and Rachel called this "The Mark of Zorro!"
Reposted by Shivani Dharmadhikari
MBL scientists use skates and their embryos to study skeletal development. By shining a light through egg cases, scientists can watch the entire maturation process.
Learn more about skates as a research organism here: bit.ly/3Rmvq3F
📹 Bioquest
Learn more about skates as a research organism here: bit.ly/3Rmvq3F
📹 Bioquest
June 25, 2025 at 2:05 PM
MBL scientists use skates and their embryos to study skeletal development. By shining a light through egg cases, scientists can watch the entire maturation process.
Learn more about skates as a research organism here: bit.ly/3Rmvq3F
📹 Bioquest
Learn more about skates as a research organism here: bit.ly/3Rmvq3F
📹 Bioquest
Reposted by Shivani Dharmadhikari
The one and only Manu @prakashlab.bsky.social
inspiring @mblscience.bsky.social Physiology students at this morning's lecture.
inspiring @mblscience.bsky.social Physiology students at this morning's lecture.
June 18, 2025 at 3:58 PM
The one and only Manu @prakashlab.bsky.social
inspiring @mblscience.bsky.social Physiology students at this morning's lecture.
inspiring @mblscience.bsky.social Physiology students at this morning's lecture.
Reposted by Shivani Dharmadhikari
A great morning with the @mblscience.bsky.social
Physiology students after my talk today.
Physiology students after my talk today.
June 17, 2025 at 5:36 PM
A great morning with the @mblscience.bsky.social
Physiology students after my talk today.
Physiology students after my talk today.
Reposted by Shivani Dharmadhikari
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Is there a pattern of how they arrange in the drop or have I been staring through the microscope for far toooo long? 🧐😁#beautifulembryos
April 24, 2025 at 10:49 AM
Is there a pattern of how they arrange in the drop or have I been staring through the microscope for far toooo long? 🧐😁#beautifulembryos
Reposted by Shivani Dharmadhikari
If you're in Europe you can watch it in French here: www.arte.tv/fr/videos/11...
March 11, 2025 at 5:59 PM
If you're in Europe you can watch it in French here: www.arte.tv/fr/videos/11...
Reposted by Shivani Dharmadhikari
New cell line = New cell morphologies to explore!
This hepatic cell line has fully invested into membrane protrusions!
Actin is shown in 🟦 and DNA in 🟧
#FluorescenceFriday
#SciArt
This hepatic cell line has fully invested into membrane protrusions!
Actin is shown in 🟦 and DNA in 🟧
#FluorescenceFriday
#SciArt
March 21, 2025 at 1:05 PM
New cell line = New cell morphologies to explore!
This hepatic cell line has fully invested into membrane protrusions!
Actin is shown in 🟦 and DNA in 🟧
#FluorescenceFriday
#SciArt
This hepatic cell line has fully invested into membrane protrusions!
Actin is shown in 🟦 and DNA in 🟧
#FluorescenceFriday
#SciArt
Reposted by Shivani Dharmadhikari
A woman studies embryos for decades, struggles for funding and respect. She publishes under her husband’s name, until they divorce. A single mother, she moves across an ocean to continue her studies. It all sounds quite modern, until you learn that she also worried she’d be burned as a witch. 🧵 1/15
March 11, 2025 at 4:04 PM
A woman studies embryos for decades, struggles for funding and respect. She publishes under her husband’s name, until they divorce. A single mother, she moves across an ocean to continue her studies. It all sounds quite modern, until you learn that she also worried she’d be burned as a witch. 🧵 1/15
Lovely work on shape evolution! Check out the story below:)
The evolution of shape diversity through the lens of physics—explored in our new paper! A fruitful collaboration between our lab @EMBL, Salbreux’s lab @unige & others, led by @BailleulRichar1—now independent at @ENS_ULM—& Nicolas Cuny. bit.ly/3WRqdEa
February 9, 2025 at 5:02 PM
Lovely work on shape evolution! Check out the story below:)
As a biologist, we have to often choose colors and the way of representation of data..but Pierre-Joseph Redouté’s plant illustrations are amazing and Nicholas Rougeux's collation and post processing and representation of data is beautiful! Lots of amazing stuff! check here - www.c82.net/work/
February 5, 2025 at 8:34 AM
As a biologist, we have to often choose colors and the way of representation of data..but Pierre-Joseph Redouté’s plant illustrations are amazing and Nicholas Rougeux's collation and post processing and representation of data is beautiful! Lots of amazing stuff! check here - www.c82.net/work/
Interesting topic and a lovely lab to work in! Don’t miss out on the opportunity!
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
January 4, 2025 at 8:21 AM
Interesting topic and a lovely lab to work in! Don’t miss out on the opportunity!
Such an important way of progressing in any scientific question, yet so undervalued!
December 27, 2024 at 9:49 AM
Such an important way of progressing in any scientific question, yet so undervalued!
There is the beast of the year!
Little hunting 🐙
And the beauty by Manon’s lovely heart!
Its nice to be a part of the yearly tradition! 🎄
Little hunting 🐙
And the beauty by Manon’s lovely heart!
Its nice to be a part of the yearly tradition! 🎄
We end the year with our now traditional Beauty and the Beast contest:
@sdharmadhikari.bsky.social
octopus and Manon's ❤️ for the win!
That's a wrap for 2024, which was particularly productive for the lab! Have a great holiday!
@sdharmadhikari.bsky.social
octopus and Manon's ❤️ for the win!
That's a wrap for 2024, which was particularly productive for the lab! Have a great holiday!
December 18, 2024 at 1:32 PM
There is the beast of the year!
Little hunting 🐙
And the beauty by Manon’s lovely heart!
Its nice to be a part of the yearly tradition! 🎄
Little hunting 🐙
And the beauty by Manon’s lovely heart!
Its nice to be a part of the yearly tradition! 🎄
Reposted by Shivani Dharmadhikari
Yes! everybody has their favorite early Metchnikoff paper (before he moved on to such secondary pursuits as discovering innate immunity). Mine: his early intuition that animals evolved from colonies of flagellates that could transdifferentiate into amoebae - 100y before molecular phylogenies!
December 7, 2024 at 2:06 PM
Yes! everybody has their favorite early Metchnikoff paper (before he moved on to such secondary pursuits as discovering innate immunity). Mine: his early intuition that animals evolved from colonies of flagellates that could transdifferentiate into amoebae - 100y before molecular phylogenies!
Check this riddle out!!☺️
This is a human embryo at 4 cell-stage, with one of the cells in mitosis. This image is from this Behind the paper story about a medical doctor stepping into a #DevBio lab @maitrejl.bsky.social to study human embryo mechanics:
thenode.biologists.com/when-a-medic...
#ACloserLook
thenode.biologists.com/when-a-medic...
#ACloserLook
December 4, 2024 at 11:15 PM
Check this riddle out!!☺️
An interesting read! An article from John Hopfield on how he chooses to work on the next question(now what?)… a question, as a scientist we often ask ourselves!
pni.princeton.edu/people/john-...
Now What?
John J. Hopfield, Princeton University, Princeton, NJ 08544, USA. October 2018 John J. Hopfield Now What? (Article in PDF format) My first full-time permanent employment was at the Bell Telephone Labo...
pni.princeton.edu
November 30, 2024 at 7:34 PM
An interesting read! An article from John Hopfield on how he chooses to work on the next question(now what?)… a question, as a scientist we often ask ourselves!
pni.princeton.edu/people/john-...
Reposted by Shivani Dharmadhikari
Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A toolkit for testing membrane localisation tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
November 12, 2024 at 11:05 PM
Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shivani Dharmadhikari
Congrats to double Doctor Julie Firmin on receiving the prize for her Great Advances in Biology from the Academie des Sciences!
November 26, 2024 at 6:54 PM
Congrats to double Doctor Julie Firmin on receiving the prize for her Great Advances in Biology from the Academie des Sciences!
Early mouse morula!
Almost two years ago, I imaged my very first mouse embryo and since then I haven’t gotten over the funny apical domains (cyan)😍 nostalgic :)
This beauty was part of the first immunostaining, I did when I joined the lab! #fluoroscentfriday
Almost two years ago, I imaged my very first mouse embryo and since then I haven’t gotten over the funny apical domains (cyan)😍 nostalgic :)
This beauty was part of the first immunostaining, I did when I joined the lab! #fluoroscentfriday
November 22, 2024 at 4:29 PM
Early mouse morula!
Almost two years ago, I imaged my very first mouse embryo and since then I haven’t gotten over the funny apical domains (cyan)😍 nostalgic :)
This beauty was part of the first immunostaining, I did when I joined the lab! #fluoroscentfriday
Almost two years ago, I imaged my very first mouse embryo and since then I haven’t gotten over the funny apical domains (cyan)😍 nostalgic :)
This beauty was part of the first immunostaining, I did when I joined the lab! #fluoroscentfriday
First snow of the year!! For someone who was used to 30 degrees all year along, snowing is special❄️🌨️ I will try to work today😉
November 21, 2024 at 10:32 AM
First snow of the year!! For someone who was used to 30 degrees all year along, snowing is special❄️🌨️ I will try to work today😉
Hatching blastocyst!
When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️
When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️
November 19, 2024 at 9:02 AM
Hatching blastocyst!
When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️
When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️
Reposted by Shivani Dharmadhikari
Ovulation filmed from start to finish for the first time
Approximately 400 times in a woman's life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh,...
weiterlesen
Approximately 400 times in a woman's life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh,...
weiterlesen
October 21, 2024 at 11:51 AM
Ovulation filmed from start to finish for the first time
Approximately 400 times in a woman's life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh,...
weiterlesen
Approximately 400 times in a woman's life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh,...
weiterlesen