Sergio Serrano-Villar
@serranovillar.bsky.social
Physician-Scientist. Hospital Ramón y Cajal, Madrid, formerly
@UCSF San Francisco.
Research in HIV, microbiome, and cancer.
@UCSF San Francisco.
Research in HIV, microbiome, and cancer.
💊 Las 3 veces que he comprado antibióticos en farmacias distintas me han ofrecido probióticos para “evitar complicaciones”.
📉 No hay evidencia sólida que respalde su uso sistemático en este contexto.
💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪
📉 No hay evidencia sólida que respalde su uso sistemático en este contexto.
💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪
October 22, 2025 at 5:47 AM
💊 Las 3 veces que he comprado antibióticos en farmacias distintas me han ofrecido probióticos para “evitar complicaciones”.
📉 No hay evidencia sólida que respalde su uso sistemático en este contexto.
💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪
📉 No hay evidencia sólida que respalde su uso sistemático en este contexto.
💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪
1/10 🧵 Proud to share results from the INSTINCT trial, published in @cidjournal.bsky.social!
A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV?
Spoiler: no
🧪
doi.org/10.1093/cid/...
A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV?
Spoiler: no
🧪
doi.org/10.1093/cid/...
Validate User
doi.org
October 14, 2025 at 2:51 PM
1/10 🧵 Proud to share results from the INSTINCT trial, published in @cidjournal.bsky.social!
A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV?
Spoiler: no
🧪
doi.org/10.1093/cid/...
A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV?
Spoiler: no
🧪
doi.org/10.1093/cid/...
Reposted by Sergio Serrano-Villar
El @csic.es difunde la concesión de la ayuda de proyectos sinérgicos de la Comunidad de Madrid a nuestro compañero Dr. Bruno Sainz junto con el Dr. Sergio Serrano-Villar @serranovillar.bsky.social del #IRYCIS
Enhorabuena a los dos grupos de investigadores👏
@dicma-csic.bsky.social
Enhorabuena a los dos grupos de investigadores👏
@dicma-csic.bsky.social
🔬 El proyecto del @iibm-csic-uam.bsky.social, con el #IRYCIS, investiga sobre el microbioma intestinal de pacientes con respuestas excepcionales a la inmunoterapia
👉 El objetivo final es descubrir fármacos para superar la resistencia en tumores refractarios a inmunoterapia
👉 El objetivo final es descubrir fármacos para superar la resistencia en tumores refractarios a inmunoterapia
August 12, 2025 at 10:10 AM
El @csic.es difunde la concesión de la ayuda de proyectos sinérgicos de la Comunidad de Madrid a nuestro compañero Dr. Bruno Sainz junto con el Dr. Sergio Serrano-Villar @serranovillar.bsky.social del #IRYCIS
Enhorabuena a los dos grupos de investigadores👏
@dicma-csic.bsky.social
Enhorabuena a los dos grupos de investigadores👏
@dicma-csic.bsky.social
Reposted by Sergio Serrano-Villar
“The Trump administration is, for the first time in history, substantially intervening inside NIH to bring it under political control,” according to a senior NIH official who spoke on condition of anonymity. My latest.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
‘It’s really, really bad right now’: NIH scientists dismayed by Trump cuts
Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work
www.theguardian.com
August 7, 2025 at 5:12 PM
“The Trump administration is, for the first time in history, substantially intervening inside NIH to bring it under political control,” according to a senior NIH official who spoke on condition of anonymity. My latest.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Reposted by Sergio Serrano-Villar
🧠 Lithium and Alzheimer’s
A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it.
🔗 www.nature.com/articles/s41...
#SciComm #Alzheimers 🧪
A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it.
🔗 www.nature.com/articles/s41...
#SciComm #Alzheimers 🧪
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...
www.nature.com
August 8, 2025 at 4:31 AM
🧠 Lithium and Alzheimer’s
A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it.
🔗 www.nature.com/articles/s41...
#SciComm #Alzheimers 🧪
A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it.
🔗 www.nature.com/articles/s41...
#SciComm #Alzheimers 🧪
Reposted by Sergio Serrano-Villar
📣Bruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramón y Cajal Hospital/IRYCIS
➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules
Congratulations Bruno!!👏
➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules
Congratulations Bruno!!👏
July 25, 2025 at 12:04 PM
📣Bruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramón y Cajal Hospital/IRYCIS
➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules
Congratulations Bruno!!👏
➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules
Congratulations Bruno!!👏
🧬 Our new paper in TMAID: Chronic Chagas disease disrupts gut microbiome metabolism.
🔻 TCA, β-oxidation & haem pathways fall
🔺 Benznidazole partly restores microbial function
💡 Biomarkers & targets for microbiota therapies
📄 doi.org/10.1016/j.tm...
🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪
🔻 TCA, β-oxidation & haem pathways fall
🔺 Benznidazole partly restores microbial function
💡 Biomarkers & targets for microbiota therapies
📄 doi.org/10.1016/j.tm...
🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪
Redirecting
doi.org
July 28, 2025 at 7:41 AM
🧬 Our new paper in TMAID: Chronic Chagas disease disrupts gut microbiome metabolism.
🔻 TCA, β-oxidation & haem pathways fall
🔺 Benznidazole partly restores microbial function
💡 Biomarkers & targets for microbiota therapies
📄 doi.org/10.1016/j.tm...
🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪
🔻 TCA, β-oxidation & haem pathways fall
🔺 Benznidazole partly restores microbial function
💡 Biomarkers & targets for microbiota therapies
📄 doi.org/10.1016/j.tm...
🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪
🧬 Gut-heart axis 2.0. 💥🦠
A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis.
🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS.
🧪Pharmacologic inhibition reversed vascular inflammation in vivo.
www.nature.com/articles/s41...
A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis.
🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS.
🧪Pharmacologic inhibition reversed vascular inflammation in vivo.
www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
www.nature.com
July 17, 2025 at 3:00 PM
🧬 Gut-heart axis 2.0. 💥🦠
A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis.
🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS.
🧪Pharmacologic inhibition reversed vascular inflammation in vivo.
www.nature.com/articles/s41...
A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis.
🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS.
🧪Pharmacologic inhibition reversed vascular inflammation in vivo.
www.nature.com/articles/s41...
🚨 A gut bacterium, Hominenteromicrobium YB328, boosts PD-1 cancer immunotherapy by activating dendritic cells & T cells.
🧬 Precision microbiome meets precision medicine.
Now heading to clinical trials 🧪
🔗 www.nature.com/articles/d41...
We’re tracking this closely as part of our RUMBA study.
🧬 Precision microbiome meets precision medicine.
Now heading to clinical trials 🧪
🔗 www.nature.com/articles/d41...
We’re tracking this closely as part of our RUMBA study.
July 15, 2025 at 6:02 PM
🚨 A gut bacterium, Hominenteromicrobium YB328, boosts PD-1 cancer immunotherapy by activating dendritic cells & T cells.
🧬 Precision microbiome meets precision medicine.
Now heading to clinical trials 🧪
🔗 www.nature.com/articles/d41...
We’re tracking this closely as part of our RUMBA study.
🧬 Precision microbiome meets precision medicine.
Now heading to clinical trials 🧪
🔗 www.nature.com/articles/d41...
We’re tracking this closely as part of our RUMBA study.
Took 4,800 years and a few stubborn molars, but we finally got the first full genome from ancient Egypt.
Mummies: still better preserved than most backup hard drives.🧪🧟♀️
🔗 www.nature.com/articles/d41...
Mummies: still better preserved than most backup hard drives.🧪🧟♀️
🔗 www.nature.com/articles/d41...
First human genome from ancient Egypt sequenced from 4,800-year-old teeth
Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ancient Egyptian.
www.nature.com
July 4, 2025 at 7:15 AM
Took 4,800 years and a few stubborn molars, but we finally got the first full genome from ancient Egypt.
Mummies: still better preserved than most backup hard drives.🧪🧟♀️
🔗 www.nature.com/articles/d41...
Mummies: still better preserved than most backup hard drives.🧪🧟♀️
🔗 www.nature.com/articles/d41...
Where do academics go when they leave for industry?
The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪
🔗 www.nature.com/articles/d41...
The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪
🔗 www.nature.com/articles/d41...
Transparent research: can big tech learn from big pharma?
The results of technology research and development must find their way into the published literature. New models of regulation could help.
www.nature.com
July 4, 2025 at 7:11 AM
Where do academics go when they leave for industry?
The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪
🔗 www.nature.com/articles/d41...
The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪
🔗 www.nature.com/articles/d41...
Reposted by Sergio Serrano-Villar
The isolated hepatitis B core antibody:
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
The Mystery of the Isolated Hepatitis B Core Antibody, Solved
(A post inspired by years of doing eConsults, an extremely common query about hepatitis B testing, and the latest BritBox series, “Core Antibody Confidential,” starring a grizzled detective with a fad...
blogs.jwatch.org
June 27, 2025 at 9:09 PM
The isolated hepatitis B core antibody:
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
💥 Big news! We’ve secured €750K for the RUMBA project through the Synergistic Projects call.
We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪
#microbiome #immunotherapy #lungcancer
We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪
#microbiome #immunotherapy #lungcancer
June 24, 2025 at 10:01 PM
💥 Big news! We’ve secured €750K for the RUMBA project through the Synergistic Projects call.
We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪
#microbiome #immunotherapy #lungcancer
We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪
#microbiome #immunotherapy #lungcancer
Reposted by Sergio Serrano-Villar
Como cada año, el taller de Sergio Serrano en #XXVIIICongresoSEIMC no se puede perder. Como convertir a la IA en tu asistente de investigación? (Si no usas la IA no pasa nada. Si la usas bien puede facilitar mucho el trabajo. Pero si la usas mal, una carrera científica puede terminarse)
May 23, 2025 at 2:27 PM
Como cada año, el taller de Sergio Serrano en #XXVIIICongresoSEIMC no se puede perder. Como convertir a la IA en tu asistente de investigación? (Si no usas la IA no pasa nada. Si la usas bien puede facilitar mucho el trabajo. Pero si la usas mal, una carrera científica puede terminarse)
More than twenty years ago, I was making coffee ☕ at PretaManger in London and learning the ropes on my first-ever salary.
Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV.
🙏 Grateful to the organizers for bringing together such a vibrant community 🌱
t.ly/S3WyZ
Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV.
🙏 Grateful to the organizers for bringing together such a vibrant community 🌱
t.ly/S3WyZ
June 7, 2025 at 8:04 AM
More than twenty years ago, I was making coffee ☕ at PretaManger in London and learning the ropes on my first-ever salary.
Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV.
🙏 Grateful to the organizers for bringing together such a vibrant community 🌱
t.ly/S3WyZ
Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV.
🙏 Grateful to the organizers for bringing together such a vibrant community 🌱
t.ly/S3WyZ
Reposted by Sergio Serrano-Villar
Dr. Jaime Altchech, jefe de servicio de Parasitología, del Hospital de Buenos Aires y uno de los referentes en investigación en enfermedad de Chagas.
👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas.
¡Gracias por la clase magistral! 👏
#NeglectedDiseases
👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas.
¡Gracias por la clase magistral! 👏
#NeglectedDiseases
June 2, 2025 at 6:39 AM
Dr. Jaime Altchech, jefe de servicio de Parasitología, del Hospital de Buenos Aires y uno de los referentes en investigación en enfermedad de Chagas.
👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas.
¡Gracias por la clase magistral! 👏
#NeglectedDiseases
👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas.
¡Gracias por la clase magistral! 👏
#NeglectedDiseases
Reposted by Sergio Serrano-Villar
If anyone is looking for a true "start" of the effective ART era for HIV, I'd vote for Jan 1996 CROI, when 24 wk data from this study were presented for the first time. Indinavir joined ritonavir (🤮) and saquinavir (😑) with full FDA approval in March.
So amazing. www.natap.org/1998/drug/03...
So amazing. www.natap.org/1998/drug/03...
May 24, 2025 at 9:36 AM
If anyone is looking for a true "start" of the effective ART era for HIV, I'd vote for Jan 1996 CROI, when 24 wk data from this study were presented for the first time. Indinavir joined ritonavir (🤮) and saquinavir (😑) with full FDA approval in March.
So amazing. www.natap.org/1998/drug/03...
So amazing. www.natap.org/1998/drug/03...
Reposted by Sergio Serrano-Villar
Un año más, estrechamos lazos con nuestr@s compañer@s de Microbiológia con el clásico nudo #SEIMC2025
🤝
🤝
May 22, 2025 at 5:45 PM
Un año más, estrechamos lazos con nuestr@s compañer@s de Microbiológia con el clásico nudo #SEIMC2025
🤝
🤝
🔬 Just out in #Microbiome: our consortium’s review highlights how #metaproteomics can reveal microbial effectors—like toxins, AMR proteins & phages—that shape microbiomes across human, animal & environmental health.
A #OneHealth perspective 🌍🧫
🔗 t.ly/P-PWh
#MicrobialEcology
A #OneHealth perspective 🌍🧫
🔗 t.ly/P-PWh
#MicrobialEcology
Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes - Microbiome
One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and ...
link.springer.com
May 23, 2025 at 1:25 PM
🔬 Just out in #Microbiome: our consortium’s review highlights how #metaproteomics can reveal microbial effectors—like toxins, AMR proteins & phages—that shape microbiomes across human, animal & environmental health.
A #OneHealth perspective 🌍🧫
🔗 t.ly/P-PWh
#MicrobialEcology
A #OneHealth perspective 🌍🧫
🔗 t.ly/P-PWh
#MicrobialEcology
Reposted by Sergio Serrano-Villar
🧵No os perdáis las novedades presentadas en seimc2025.org
📍#SEIMC2025 arranca con fuerza 💪
Aquí un hilo con nuestras aportaciones 👇
📍#SEIMC2025 arranca con fuerza 💪
Aquí un hilo con nuestras aportaciones 👇
May 22, 2025 at 11:46 AM
🧵No os perdáis las novedades presentadas en seimc2025.org
📍#SEIMC2025 arranca con fuerza 💪
Aquí un hilo con nuestras aportaciones 👇
📍#SEIMC2025 arranca con fuerza 💪
Aquí un hilo con nuestras aportaciones 👇
Reposted by Sergio Serrano-Villar
Caso clínico: 👩⚖️
♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).
♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).
May 9, 2025 at 7:26 AM
Caso clínico: 👩⚖️
♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).
♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).
Reposted by Sergio Serrano-Villar
🎓Excelente revisión sobre terapia nebulizada en pacientes hematológicos. Dr. Jesús Fortún.
✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq
✅ La terapia nebulizada en pfx es prometedora
✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq
✅ La terapia nebulizada en pfx es prometedora
May 6, 2025 at 6:54 AM
🎓Excelente revisión sobre terapia nebulizada en pacientes hematológicos. Dr. Jesús Fortún.
✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq
✅ La terapia nebulizada en pfx es prometedora
✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq
✅ La terapia nebulizada en pfx es prometedora
Reposted by Sergio Serrano-Villar
📣 Imperial College Research Fellowships!
Prestigious 4yr fellowship
✔️ Salary from £48k
✔️ Up to £45k for research
✔️ A supportive, inclusive research environment
✔️ UK or international
✔️ <4 yrs post-PhD
Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93
Prestigious 4yr fellowship
✔️ Salary from £48k
✔️ Up to £45k for research
✔️ A supportive, inclusive research environment
✔️ UK or international
✔️ <4 yrs post-PhD
Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93
May 5, 2025 at 1:17 PM
📣 Imperial College Research Fellowships!
Prestigious 4yr fellowship
✔️ Salary from £48k
✔️ Up to £45k for research
✔️ A supportive, inclusive research environment
✔️ UK or international
✔️ <4 yrs post-PhD
Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93
Prestigious 4yr fellowship
✔️ Salary from £48k
✔️ Up to £45k for research
✔️ A supportive, inclusive research environment
✔️ UK or international
✔️ <4 yrs post-PhD
Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93
Reposted by Sergio Serrano-Villar
Very sensible take on Covid (and other infections) in kids for 2025.
I'm an epidemiologist and a father. I'm not overly concerned about COVID-19 and my daughter's health now in 2025.
Here's why:
gidmk.substack.com/p/children-a...
Here's why:
gidmk.substack.com/p/children-a...
Children And COVID-19 In 2025
Why I'm not overly concerned about my daughter and COVID-19
gidmk.substack.com
January 7, 2025 at 12:18 PM
Very sensible take on Covid (and other infections) in kids for 2025.