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Reposted by Sergio Serrano-Villar

Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) @iib.uam.es · Aug 12

El @csic.es difunde la concesión de la ayuda de proyectos sinérgicos de la Comunidad de Madrid a nuestro compañero Dr. Bruno Sainz junto con el Dr. Sergio Serrano-Villar @serranovillar.bsky.social del #IRYCIS
Enhorabuena a los dos grupos de investigadores👏

@dicma-csic.bsky.social

CSIC @csic.es · Aug 5

🔬 El proyecto del @iibm-csic-uam.bsky.social, con el #IRYCIS, investiga sobre el microbioma intestinal de pacientes con respuestas excepcionales a la inmunoterapia

👉 El objetivo final es descubrir fármacos para superar la resistencia en tumores refractarios a inmunoterapia

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Reposted by Sergio Serrano-Villar

Hannah Harris Green @greennoise.bsky.social · Aug 7

“The Trump administration is, for the first time in history, substantially intervening inside NIH to bring it under political control,” according to a senior NIH official who spoke on condition of anonymity. My latest.

www.theguardian.com/us-news/2025...

‘It’s really, really bad right now’: NIH scientists dismayed by Trump cuts

Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work

www.theguardian.com

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Reposted by Sergio Serrano-Villar

Prof Sam Illingworth @samillingworth.com · Aug 8

🧠 Lithium and Alzheimer’s

A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it.

🔗 www.nature.com/articles/s41...

#SciComm #Alzheimers 🧪

Lithium deficiency and the onset of Alzheimer’s disease - Nature

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...

www.nature.com

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Reposted by Sergio Serrano-Villar

Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) @iib.uam.es · Jul 25

📣Bruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramón y Cajal Hospital/IRYCIS

➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules

Congratulations Bruno!!👏

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 28

🧬 Our new paper in TMAID: Chronic Chagas disease disrupts gut microbiome metabolism.

🔻 TCA, β-oxidation & haem pathways fall
🔺 Benznidazole partly restores microbial function
💡 Biomarkers & targets for microbiota therapies
📄 doi.org/10.1016/j.tm...

🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪

Redirecting

doi.org

Sergio Serrano-Villar @serranovillar.bsky.social · Jul 28

Beautiful research, thank you!🎉🎊

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 18

📣 HIV responses can’t hinge on political shifts.
✊🏾 We need stable, committed funding—not abandonment.🧪
#PEPFAR #HIV #FundingCrisis #GlobalHealth #IAS2025

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 18

💥 #IAS2025 | #HIV Global Alert 💥

The abrupt US funding cuts are already hitting hard:
📉 Mozambique: 25% drop in ART initiations/month
📉 Johannesburg: 30% drop in testing, diagnoses & ART/year
🌍 Latin America & Caribbean: 87% of orgs lost funding

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 17

🧬 Gut-heart axis 2.0. 💥🦠

A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis.

🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS.

🧪Pharmacologic inhibition reversed vascular inflammation in vivo.
www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

www.nature.com

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 15

🚨 A gut bacterium, Hominenteromicrobium YB328, boosts PD-1 cancer immunotherapy by activating dendritic cells & T cells.

🧬 Precision microbiome meets precision medicine.

Now heading to clinical trials 🧪

🔗 www.nature.com/articles/d41...

We’re tracking this closely as part of our RUMBA study.

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 4

Took 4,800 years and a few stubborn molars, but we finally got the first full genome from ancient Egypt.

Mummies: still better preserved than most backup hard drives.🧪🧟‍♀️
🔗 www.nature.com/articles/d41...

First human genome from ancient Egypt sequenced from 4,800-year-old teeth

Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ancient Egyptian.

www.nature.com

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Sergio Serrano-Villar @serranovillar.bsky.social · Jul 4

Where do academics go when they leave for industry?

The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪
🔗 www.nature.com/articles/d41...

Transparent research: can big tech learn from big pharma?

The results of technology research and development must find their way into the published literature. New models of regulation could help.

www.nature.com

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Reposted by Sergio Serrano-Villar

Paul Sax @paulsaxmd.bsky.social · Jun 27

The isolated hepatitis B core antibody:
HBsAg ⛔
anti-HBs ⛔
anti-HBc ✅
What does it mean, and what should you do?
A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...

The Mystery of the Isolated Hepatitis B Core Antibody, Solved

(A post inspired by years of doing eConsults, an extremely common query about hepatitis B testing, and the latest BritBox series, “Core Antibody Confidential,” starring a grizzled detective with a fad...

blogs.jwatch.org

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Sergio Serrano-Villar @serranovillar.bsky.social · Jun 24

💥 Big news! We’ve secured €750K for the RUMBA project through the Synergistic Projects call.

We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪

#microbiome #immunotherapy #lungcancer

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Sergio Serrano-Villar @serranovillar.bsky.social · Jun 24

Thanks!

Reposted by Sergio Serrano-Villar

Jesica Abadia @jessabbey.bsky.social · May 23

Como cada año, el taller de Sergio Serrano en #XXVIIICongresoSEIMC no se puede perder. Como convertir a la IA en tu asistente de investigación? (Si no usas la IA no pasa nada. Si la usas bien puede facilitar mucho el trabajo. Pero si la usas mal, una carrera científica puede terminarse)

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Sergio Serrano-Villar @serranovillar.bsky.social · Jun 7

Hi Erik, here a physician-scientist in the microbiome field. Can you please add me to the feed? 🙏 orcid.org/0000-0002-54...

ORCID

orcid.org

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Sergio Serrano-Villar @serranovillar.bsky.social · Jun 7

More than twenty years ago, I was making coffee ☕ at PretaManger in London and learning the ropes on my first-ever salary.

Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV.

🙏 Grateful to the organizers for bringing together such a vibrant community 🌱

t.ly/S3WyZ

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Reposted by Sergio Serrano-Villar

Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · Jun 2

Dr. Jaime Altchech, jefe de servicio de Parasitología, del Hospital de Buenos Aires y uno de los referentes en investigación en enfermedad de Chagas.

👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas.

¡Gracias por la clase magistral! 👏

#NeglectedDiseases

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Sergio Serrano-Villar @serranovillar.bsky.social · May 30

5. Scheduling meetings about scheduling meetings to discuss future meetings.

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Reposted by Sergio Serrano-Villar

Paul Sax @paulsaxmd.bsky.social · May 24

If anyone is looking for a true "start" of the effective ART era for HIV, I'd vote for Jan 1996 CROI, when 24 wk data from this study were presented for the first time. Indinavir joined ritonavir (🤮) and saquinavir (😑) with full FDA approval in March.
So amazing. www.natap.org/1998/drug/03...

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Reposted by Sergio Serrano-Villar

Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · May 22

Un año más, estrechamos lazos con nuestr@s compañer@s de Microbiológia con el clásico nudo #SEIMC2025
🤝

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Sergio Serrano-Villar @serranovillar.bsky.social · May 23

¡Gracias a #SEIMC2024 por la invitación y a la suficiencia por haber participado en este debate fascinante!

Seguiremos profundizando en el tema 🤖

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Sergio Serrano-Villar @serranovillar.bsky.social · May 23

¡Gracias por el comentario! Cierto, no hablamos lo suficiente del impacto energético de cada interacción.

Sergio Serrano-Villar @serranovillar.bsky.social · May 23

🔬 Just out in #Microbiome: our consortium’s review highlights how #metaproteomics can reveal microbial effectors—like toxins, AMR proteins & phages—that shape microbiomes across human, animal & environmental health.

A #OneHealth perspective 🌍🧫

🔗 t.ly/P-PWh

#MicrobialEcology

Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes - Microbiome

One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and ...

link.springer.com

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