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Reposted by Silvia Cappello

Italian Glia Network @italianglianetwork.bsky.social · 5d

Application to present at the Second Italian Glia Network Symposium is closing next week. Apply your abstract by Oct 10!!! Do not miss the opportunity to discuss your research in a young and informal community !!! #Glia

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Science Magazine @science.org · Sep 5

New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO

A coronal section of an embryonic mouse brain with the Galectin-3 protein removed, visualized with immunofluorescence.

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Reposted by Silvia Cappello

FAU Erlangen-Nbg @fau.de · Sep 3

Neue Heisenberg-Professur für die FAU: Prof. Dr. Ruth Beckervordersandforth wird von der @dfg.de‬ gefördert 👏

Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren.

Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...

Neue Heisenberg-Professur für die FAU

Großer Erfolg für die FAU: Die Deutsche Forschungsgemeinschaft (DFG) hat Prof. Dr. Ruth Beckervordersandforth, Professur für Molekulare Neuropathologie an der Friedrich-Alexander-Universität Erlangen…

www.fau.de

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Deutsche Forschungsgemeinschaft @dfg.de · May 22

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

Map of Germany with the Clusters of Excellence

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Nereo Kalebic @nereokalebic.bsky.social · May 21

Three amazing days of the #neurogen2025 conference at @humantechnopole.bsky.social in Milan. Many thanks to all the participants, speakers and fellow co-organizers. We heard fantastic talks in #neurodevelopment #brainevolution #cancerneuroscience #neuroimmunology #neurodegeneration #neurodiversity

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Silvia Cappello @silvianeuro.bsky.social · May 21

Fantastic work Debby! Congratulations

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Debby Silver @debbysilver.bsky.social · May 14

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

www.nature.com

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Cedric Boeckx @cedricboeckx.bsky.social · May 15

Excellent work from @silvianeuro.bsky.social lab, led by a brilliant young scholar, @mveronicapravata.bsky.social, on
the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors
(Nice to see work going beyond the cortex) 🧪🧠🧬🧫

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

Comparative anatomical studies of primates and extinct hominins, including Neanderthals, show that the modern human brain is characterised by a disproportionately enlarged neocortex relative to the st...

www.biorxiv.org

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Silvia Cappello @silvianeuro.bsky.social · May 15

Thanks Cedric!

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Frédéric Causeret @fredcauseret.bsky.social · May 8

Latest publication from the lab just out in @dev-journal.bsky.social.
Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells...
doi.org/10.1242/dev....
Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky

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Silvia Cappello @silvianeuro.bsky.social · May 5

pmc.ncbi.nlm.nih.gov/articles/PMC...

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease

The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations. Lissencephaly, a severe corti...

pmc.ncbi.nlm.nih.gov

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Silvia Cappello @silvianeuro.bsky.social · May 2

Regional differences in progenitor metabolism shape brain growth during development: Cell www.cell.com/cell/fulltex...

Regional differences in progenitor metabolism shape brain growth during development

Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient, forebrain neurogenesis is temporally sustained through spatiotemporal regulation of progenitor mitochondrial functi...

www.cell.com

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Silvia Cappello @silvianeuro.bsky.social · May 1

Exploring human brain development and disease using assembloids: Neuron www.cell.com/neuron/fullt...

Exploring human brain development and disease using assembloids

Wu and Nowakowski review the progression of in vitro human brain models, highlighting the applications of assembloids in studying development and disease. They further discuss the current challenges a...

www.cell.com

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Silvia Cappello @silvianeuro.bsky.social · Apr 11

www.sciencedirect.com/science/arti...

Cellular interplay in brain organoids: Connecting cell-autonomous and non-cell-autonomous mechanisms in neurodevelopmental disease

The field of brain organoids has experienced a period of rapid and transformative growth, enabling researchers to investigate complex human biological…

www.sciencedirect.com

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Silvia Cappello @silvianeuro.bsky.social · Mar 23

www.nature.com/articles/s41...

Cancer research needs neuroscience and neuroscientists - Nature Neuroscience

The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...

www.nature.com

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Boyan Bonev @boyanbonev.bsky.social · Mar 13

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development

The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

www.biorxiv.org

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mareikealbert.bsky.social @mareikealbert.bsky.social · Mar 13

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!

www.biorxiv.org/content/10.1...

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Sergiu P. Pasca @sergiuppasca.bsky.social · Mar 14

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

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Neurotransmission and Purinergic Signaling Lab @neuropursignal.bsky.social · Mar 13

This detailed volume explores techniques for the study of neurogenic niches and neural lineage progression, specifically addressing major methodological challenges in studying neural stem cells (NSCs) and related cell populations, such as astrocytes, oligodendrocytes, and neurons.

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Silvia Cappello @silvianeuro.bsky.social · Mar 13

Thanks David 🍀

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Silvia Cappello @silvianeuro.bsky.social · Mar 9

...excited to be back home ☺️

Max Planck Institute of Psychiatry @mpi-psychiatry.bsky.social · Feb 28

📅 Next week, @silvianeuro.bsky.social from @bmc-lmu.bsky.social will share her research on early brain development, hosted by our director @binderlabmpip.bsky.social. The talk will take place at our MPI in Munich and is open to everyone!

🔗 All details here: www.psych.mpg.de/seminars

#neuroskyence

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Silvia Cappello @silvianeuro.bsky.social · Mar 6

Aging activates escape of the silent X chromosome in the female mouse hippocampus | Science Advances www.science.org/doi/10.1126/...

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

www.science.org

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Silvia Cappello @silvianeuro.bsky.social · Feb 21

Congratulations Marisa!!!! 🤩🥳

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Cedric Boeckx @cedricboeckx.bsky.social · Feb 14

Three fantastic @science.org papers on convergent development & evolution of neurons + their connections in the bird &
mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno.
Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠

Constrained roads to complex brains

Neural development and brain circuit evolution converged in birds and mammals

www.science.org

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Esther Klingler @estherkli.bsky.social · Feb 20

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...

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