LightNews
stevethechemist.bsky.social
Prof Steven Lee
@stevethechemist.bsky.social
77 followers 16 following 7 posts
Professor of Biophysical Chemistry - Cambridge University | Co-founder - ZOMP | Podcaster - TheScienceShed
Posts Media Videos Starter Packs
Reposted by Prof Steven Lee
weisslab.bsky.social
Lucien Weiss @weisslab.bsky.social · 8d
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
crick.ac.uk
The Francis Crick Institute @crick.ac.uk · 8d
Researchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments.

www.crick.ac.uk/news/2025-10...
Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time
A team of scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease. Their new technique, published today in Nature Biomedica...
www.crick.ac.uk
1 5
Reposted by Prof Steven Lee
jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · 8d
www.nature.com/articles/s41...

It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering
An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.
www.nature.com
1 3
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · 8d
Our work on visualising protein aggregates in human brain tissue in Parkinson's disease was published today in Nature Biomedical Engineering, well done to Becs, Bin and Christina for their hardwork!
www.cam.ac.uk/research/new...
Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time
Scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s, marking a major advance in the
www.cam.ac.uk
9 41
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · 29d
Last day to apply!
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Sep 1
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term) | Yusuf Hamied Department of Chemistry
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for a...
www.ch.cam.ac.uk
1
Reposted by Prof Steven Lee
jamesrevans.bsky.social
James R Evans @jamesrevans.bsky.social · Sep 1
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.

www.biorxiv.org/content/10.1...

Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
www.biorxiv.org
6 6
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Sep 1
Wonderful news Kim, well done!
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Sep 1
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term) | Yusuf Hamied Department of Chemistry
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for a...
www.ch.cam.ac.uk
2 3
Reposted by Prof Steven Lee
lewlab.com
Lew Lab @ WashU @lewlab.com · Dec 26
Top-right image is from Ezra and the Lee lab's beautiful POLCAM work of actin fiber networks. The POLCAM software is much easier to use than full PSF fitting: doi.org/10.1038/s415...
POLCAM: instant molecular orientation microscopy for the life sciences - Nature Methods
Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-r...
doi.org
1 1 3
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Aug 14
Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term)
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for
www.cam.ac.uk
2
Reposted by Prof Steven Lee
astormic.bsky.social
Amir Rahmani @astormic.bsky.social · Apr 7
A room full of microscopy enthusiasts, Cambridge Microscopy Meeting 2025. #CMM2025
2 3 10
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Mar 4
You wont believe what happens next!?!? theevanslab.bsky.social! //run"(Insert_click_bate_that_Nick_will_fall_for"); soundcloud.com/the-science-...
S6 E1: Spies, Lies and Simeticone
Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un
soundcloud.com
1
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Feb 28
We back for the launch of Series 6 of The Science Shed! Nick’s uncovered some Cold War espionage, Steve’s brought along a surprise audio gift, and there’s plenty of snake oil to go around.
Share to and repost!
soundcloud.com/the-science-...
S6 E1: Spies, Lies and Simeticone
Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un
soundcloud.com
2
Reposted by Prof Steven Lee
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Jan 31
A recent preprint by Team Wood describes a highly sensitive bioimaging method that allows for fluorescent signals to be detected in cell and tissue environments. 🧪🤖📈 🧬

www.biorxiv.org/content/10.1...
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
1 2