Lucien Weiss
@weisslab.bsky.social
Assoc. Prof @polymtl @transmedtech
Cell biophysics, superres microscopy, & curious-methods enthusiast.
We have open positions www.WeissLab.ca
Cell biophysics, superres microscopy, & curious-methods enthusiast.
We have open positions www.WeissLab.ca
Reposted by Lucien Weiss
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
November 24, 2025 at 5:50 PM
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Reposted by Lucien Weiss
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence
engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:03 AM
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
Reposted by Lucien Weiss
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
www.nature.com
November 7, 2025 at 10:16 AM
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Lucien Weiss
Reposted by Lucien Weiss
Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
October 29, 2025 at 11:30 AM
Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Lucien Weiss
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com
PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com
www.findaphd.com
October 22, 2025 at 8:29 AM
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
October 17, 2025 at 12:23 PM
Reposted by Lucien Weiss
Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca
October 8, 2025 at 6:10 PM
Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
Reposted by Lucien Weiss
I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
August 13, 2025 at 3:24 PM
I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
Researchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments.
www.crick.ac.uk/news/2025-10...
www.crick.ac.uk/news/2025-10...
Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time
A team of scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease. Their new technique, published today in Nature Biomedica...
www.crick.ac.uk
October 2, 2025 at 2:56 AM
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
Reposted by Lucien Weiss
The culmination of many years work. One of the most advanced light-sheet microscopes in the world!
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
September 28, 2025 at 6:33 PM
The culmination of many years work. One of the most advanced light-sheet microscopes in the world!
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
Reposted by Lucien Weiss
RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
September 19, 2025 at 3:45 PM
RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Reposted by Lucien Weiss
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia
Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting
endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins
while suppressing their relea...
www.cell.com
September 10, 2025 at 7:26 AM
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
Reposted by Lucien Weiss
Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
September 8, 2025 at 9:20 PM
Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Reposted by Lucien Weiss
New article online: Ångström-tunable polarization-resolved solid-state photon sources.
go.nature.com/4gdVWYR
go.nature.com/4gdVWYR
Ångström-tunable polarization-resolved solid-state photon sources - Nature Photonics
A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwid...
go.nature.com
September 9, 2025 at 5:25 AM
New article online: Ångström-tunable polarization-resolved solid-state photon sources.
go.nature.com/4gdVWYR
go.nature.com/4gdVWYR
Reposted by Lucien Weiss
Reconstructing long-range axons from dense brain images is tough.
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
September 7, 2025 at 10:01 AM
Reconstructing long-range axons from dense brain images is tough.
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
Reposted by Lucien Weiss
New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.
go.nature.com/4m0Tc2e
go.nature.com/4m0Tc2e
Extreme-ultraviolet spatiotemporal vortices via high harmonic generation - Nature Photonics
The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these l...
go.nature.com
September 2, 2025 at 11:22 PM
New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.
go.nature.com/4m0Tc2e
go.nature.com/4m0Tc2e
Reposted by Lucien Weiss
Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.
September 2, 2025 at 8:59 AM
Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.
Reposted by Lucien Weiss
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
August 26, 2025 at 9:11 PM
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
Reposted by Lucien Weiss
🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 25, 2025 at 9:06 AM
🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lucien Weiss
There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...
a blue sign that says we are hiring
ALT: a blue sign that says we are hiring
media.tenor.com
August 14, 2025 at 8:44 PM
There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted by Lucien Weiss
Can we learn motion models from post-processed tracks? 🧐
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
How Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks?
Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy...
arxiv.org
August 12, 2025 at 8:52 PM
Can we learn motion models from post-processed tracks? 🧐
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
Reposted by Lucien Weiss
It's out & hot 🔥 Not only because it just went online but since we show that engineered heat patterns are super effective in manipulating fluid flows & particles.
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡
Three-dimensional optofluidic control using reconfigurable thermal barriers - Nature Photonics
A fluidic system with spatially reconfigurable hot spots generated by optical pumping of plasmonic nanorods is demonstrated, creating virtual barriers by generating local heating via photothermal conv...
www.nature.com
August 8, 2025 at 12:17 PM
It's out & hot 🔥 Not only because it just went online but since we show that engineered heat patterns are super effective in manipulating fluid flows & particles.
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡
Reposted by Lucien Weiss
New open access article online: Microscale generation and control of nanosecond light by light in a liquid crystal.
go.nature.com/3H0mT5a
go.nature.com/3H0mT5a
August 7, 2025 at 10:37 PM
New open access article online: Microscale generation and control of nanosecond light by light in a liquid crystal.
go.nature.com/3H0mT5a
go.nature.com/3H0mT5a