Lucien Weiss
@weisslab.bsky.social
Assoc. Prof @polymtl @transmedtech
Cell biophysics, superres microscopy, & curious-methods enthusiast.
We have open positions www.WeissLab.ca
Cell biophysics, superres microscopy, & curious-methods enthusiast.
We have open positions www.WeissLab.ca
Reposted by Lucien Weiss
Continuous mass photometry by single molecule trapping https://www.biorxiv.org/content/10.64898/2026.02.02.703204v1
February 3, 2026 at 9:47 PM
Continuous mass photometry by single molecule trapping https://www.biorxiv.org/content/10.64898/2026.02.02.703204v1
Reposted by Lucien Weiss
Ragaller, F., Sjule, E., Urem, Y. B., ..., Blom, H., & Sezgin, E. (2024). Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements. The journal of physical chemistry. B, 128(9), 2154–2167. #EpithelialMechanics
buff.ly/YjCWSfP
buff.ly/YjCWSfP
February 3, 2026 at 11:00 AM
Ragaller, F., Sjule, E., Urem, Y. B., ..., Blom, H., & Sezgin, E. (2024). Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements. The journal of physical chemistry. B, 128(9), 2154–2167. #EpithelialMechanics
buff.ly/YjCWSfP
buff.ly/YjCWSfP
Reposted by Lucien Weiss
A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons.
🔗 buff.ly/WRdybO3
🔗 buff.ly/WRdybO3
January 28, 2026 at 11:28 PM
A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons.
🔗 buff.ly/WRdybO3
🔗 buff.ly/WRdybO3
Reposted by Lucien Weiss
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
January 13, 2026 at 4:57 AM
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Reposted by Lucien Weiss
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
December 16, 2025 at 12:11 PM
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Reposted by Lucien Weiss
New paper out! Combining single-objective light-sheet microscopy and time-resolved SPAD array detection, we massively accelerate fluorescence lifetime imaging (FLIM) compared to confocal FLIM, making FLIM applicable to 3D specimen such as organoids and embryos.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
December 15, 2025 at 10:24 AM
New paper out! Combining single-objective light-sheet microscopy and time-resolved SPAD array detection, we massively accelerate fluorescence lifetime imaging (FLIM) compared to confocal FLIM, making FLIM applicable to 3D specimen such as organoids and embryos.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Lucien Weiss
The new version of TrackMate, the v8.1 has just been released. It builds upon the recent v8, linked below, and offers two main improvements 👇
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
December 10, 2025 at 1:13 PM
The new version of TrackMate, the v8.1 has just been released. It builds upon the recent v8, linked below, and offers two main improvements 👇
Reposted by Lucien Weiss
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
November 24, 2025 at 5:50 PM
📢 Paper alert 📢
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:
doi.org/10.1038/s415...
Here comes a 🧵 ... (1/9)
Reposted by Lucien Weiss
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence
engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:03 AM
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
Reposted by Lucien Weiss
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
www.nature.com
November 7, 2025 at 10:16 AM
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Lucien Weiss
Reposted by Lucien Weiss
Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
October 29, 2025 at 11:30 AM
Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Lucien Weiss
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com
PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com
www.findaphd.com
October 22, 2025 at 8:29 AM
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
October 17, 2025 at 12:23 PM
Reposted by Lucien Weiss
Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca
October 8, 2025 at 6:10 PM
Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
publicationsduquebec.gouv.qc.ca/fileadmin/ga...
Reposted by Lucien Weiss
I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
August 13, 2025 at 3:24 PM
I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
Researchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments.
www.crick.ac.uk/news/2025-10...
www.crick.ac.uk/news/2025-10...
Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time
A team of scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease. Their new technique, published today in Nature Biomedica...
www.crick.ac.uk
October 2, 2025 at 2:56 AM
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
Reposted by Lucien Weiss
The culmination of many years work. One of the most advanced light-sheet microscopes in the world!
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
September 28, 2025 at 6:33 PM
The culmination of many years work. One of the most advanced light-sheet microscopes in the world!
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!
For details see previous posts and here: github.com/amsikking/HT...
Reposted by Lucien Weiss
RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
September 19, 2025 at 3:45 PM
RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
Reposted by Lucien Weiss
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia
Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting
endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins
while suppressing their relea...
www.cell.com
September 10, 2025 at 7:26 AM
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
Reposted by Lucien Weiss
Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
September 8, 2025 at 9:20 PM
Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Reposted by Lucien Weiss
New article online: Ångström-tunable polarization-resolved solid-state photon sources.
go.nature.com/4gdVWYR
go.nature.com/4gdVWYR
Ångström-tunable polarization-resolved solid-state photon sources - Nature Photonics
A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwid...
go.nature.com
September 9, 2025 at 5:25 AM
New article online: Ångström-tunable polarization-resolved solid-state photon sources.
go.nature.com/4gdVWYR
go.nature.com/4gdVWYR
Reposted by Lucien Weiss
Reconstructing long-range axons from dense brain images is tough.
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
September 7, 2025 at 10:01 AM
Reconstructing long-range axons from dense brain images is tough.
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM
Reposted by Lucien Weiss
New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.
go.nature.com/4m0Tc2e
go.nature.com/4m0Tc2e
Extreme-ultraviolet spatiotemporal vortices via high harmonic generation - Nature Photonics
The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these l...
go.nature.com
September 2, 2025 at 11:22 PM
New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.
go.nature.com/4m0Tc2e
go.nature.com/4m0Tc2e