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Reposted by Lucien Weiss

Jean-François Cliche @clicjf.bsky.social · 2d

Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...

publicationsduquebec.gouv.qc.ca

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Reposted by Lucien Weiss

Kristen Verhey @kjverhey1.bsky.social · Aug 13

I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.

Journal of Cell Biology @jcb.org · Aug 11

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

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Lucien Weiss @weisslab.bsky.social · 9d

"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆

The Francis Crick Institute @crick.ac.uk · 10d

Researchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments.

www.crick.ac.uk/news/2025-10...

Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time

A team of scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease. Their new technique, published today in Nature Biomedica...

www.crick.ac.uk

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Reposted by Lucien Weiss

Alfred Millett-Sikking @amsikking.bsky.social · 12d

The culmination of many years work. One of the most advanced light-sheet microscopes in the world!

-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!

For details see previous posts and here: github.com/amsikking/HT...

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Reposted by Lucien Weiss

Nate Corley @ncorley.bsky.social · 22d

RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.

Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!

Check it out: lnkd.in/eiUFfJaM.

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Reposted by Lucien Weiss

Lotte B. Pedersen @lottepedersen.bsky.social · Sep 10

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

www.cell.com

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Reposted by Lucien Weiss

The Science of Parkinson's @scienceofpd.bsky.social · Sep 8

Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...

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Reposted by Lucien Weiss

Nature Photonics @natphoton.nature.com · Sep 9

New article online: Ångström-tunable polarization-resolved solid-state photon sources.

go.nature.com/4gdVWYR

Ångström-tunable polarization-resolved solid-state photon sources - Nature Photonics

A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwid...

go.nature.com

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Reposted by Lucien Weiss

eLife @elife.bsky.social · Sep 7

Reconstructing long-range axons from dense brain images is tough.

This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM

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Reposted by Lucien Weiss

Nature Photonics @natphoton.nature.com · Sep 2

New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.

go.nature.com/4m0Tc2e

Extreme-ultraviolet spatiotemporal vortices via high harmonic generation - Nature Photonics

The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these l...

go.nature.com

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Reposted by Lucien Weiss

Jonatan Alvelid @jonatanalvelid.bsky.social · Sep 2

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

Demonstrative schematics and example timeline of event-triggered MINFLUX microscopy.

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Reposted by Lucien Weiss

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 26

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

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Reposted by Lucien Weiss

Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · Aug 25

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...

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Reposted by Lucien Weiss

Rita Strack @ritastrack.bsky.social · Aug 14

There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...

a blue sign that says we are hiring

ALT: a blue sign that says we are hiring

media.tenor.com

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Reposted by Lucien Weiss

Steve Pressé @labpresse.bsky.social · Aug 12

Can we learn motion models from post-processed tracks? 🧐
Not really 😢

Emission noise accounts for ~99% of the likelihood.

TLDR: What you think is anomalous diffusion… might just be noise. 🤷‍♂️🤷‍♂️🤷‍♂️🤷‍♂️

🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599

#Biophysics

How Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks?

Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy...

arxiv.org

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Lucien Weiss @weisslab.bsky.social · Aug 9

Our resident mischief engineer/entrepreneur, Khatuli!

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Reposted by Lucien Weiss

Falko Schmidt @falkoschmidt.bsky.social · Aug 8

It's out & hot 🔥 Not only because it just went online but since we show that engineered heat patterns are super effective in manipulating fluid flows & particles.
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡

Three-dimensional optofluidic control using reconfigurable thermal barriers - Nature Photonics

A fluidic system with spatially reconfigurable hot spots generated by optical pumping of plasmonic nanorods is demonstrated, creating virtual barriers by generating local heating via photothermal conv...

www.nature.com

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Reposted by Lucien Weiss

Nature Photonics @natphoton.nature.com · Aug 7

New open access article online: Microscale generation and control of nanosecond light by light in a liquid crystal.

go.nature.com/3H0mT5a

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Reposted by Lucien Weiss

bioRxiv Biophysics @biorxiv-biophys.bsky.social · Aug 7

Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy https://www.biorxiv.org/content/10.1101/2025.08.05.668682v1

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Reposted by Lucien Weiss

Bose-Einstein-Kondensat @mwnautilus.bsky.social · Aug 2

#PALH: How to convert a #3Dprinter to a personal #automated #OpenSource #liquid #handler for life #science workflows:

- based on #Ender3
- cost: US $400
- #PCR setup, #DNA purification using #magnetic beads

doi.org/10.1016/j.sl...
#DIYbio #DIYchem #chemistry #lab #instruments #pipet #automation

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Reposted by Lucien Weiss

The Wyss Institute at Harvard University @wyssinstitute.bsky.social · Aug 2

Wyss scientists have invented a novel metabolic labeling technology that enables the “tagging” of the surface of T cells with immune-enhancing cytokine molecules, which could help expand adoptive T cell therapies to the treatment of solid tumors.

Metabolically Labeled CAR-T Cells Against Cancer

Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to…

buff.ly

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Reposted by Lucien Weiss

Luciano A. Masullo @lumasullo.bsky.social · Jul 30

Ångström-resolution imaging of cell-surface glycans

Now published in Nature Nanotechnology! 🤩
@natnano.nature.com

www.nature.com/articles/s41...

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Reposted by Lucien Weiss

The Science of Parkinson's @scienceofpd.bsky.social · Jul 30

Pieces of the puzzle coming together: Researchers report #Parkinsons-associated GBA1 mutations impair Sonic Hedgehog signaling & Hedgehog-dependent neuroprotective factor production by a distinct mechanism
www.pnas.org/doi/10.1073/...

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Reposted by Lucien Weiss

Doug Shepherd @dpshepherd.bsky.social · Jul 26

Tensorstore is much faster for read/write than vanilla zarr. Tools are here: github.com/QI2lab/opm-p...

Currently we only support our custom pymmcore-plus OPM format and ASI’s OPM format. Happy to work with you to support CZI LLSM files if you open an issue and provide some example data.

GitHub - QI2lab/opm-processing-v2: Code for fast deconvolution, deskewing, registration, and fusion of OPM/diSPIM/LLSM data.

Code for fast deconvolution, deskewing, registration, and fusion of OPM/diSPIM/LLSM data. - QI2lab/opm-processing-v2

github.com

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Reposted by Lucien Weiss

Claudia Contini @continiclau.bsky.social · Jul 14

🎉Just out in @chemcomm.rsc.org! We present a modular strategy to create bacterial #biohybrids with magnetic motility, #biosensing and cargo release.
👏🏻huge congrats to Nina on her first first-author paper and thanks to Yuval and Matt for the great collaboration! pubs.rsc.org/en/content/a... @rsc.org

Microfluidic generation of bacterial biohybrids for magnetic guidance and content release

Bacterial biohybrids use bacterial and synthetic components for biotechnological applications. Here, we outline an adaptable and high-throughput microfluidic platform to create microscale biocontained...

pubs.rsc.org

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