Lotte B. Pedersen
LightNews LightNews
lottepedersen.bsky.social
Lotte B. Pedersen
@lottepedersen.bsky.social
180 followers 170 following 28 posts
Cell biologist interested in cilia research
Posts Replies Media Videos
Reposted by Lotte B. Pedersen
focalplane.bsky.social
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!

To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
JCS snapshots: the cilia and flagella edition - FocalPlane
JCS snapshots: the cilia and flagella edition - News
focalplane.biologists.com
November 25, 2025 at 12:29 PM
Reposted by Lotte B. Pedersen
cilialab.bsky.social
And we’ll be back for four sessions in 2026- first 14/01/2026! Register: www.eventbrite.co.uk/e/bscb-genso...
#UKCilia2025 /9
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
www.eventbrite.co.uk
November 25, 2025 at 7:27 PM
Reposted by Lotte B. Pedersen
cilialab.bsky.social
In the meantime, try a deep dive into our JCS Special Issue on Cilia and Flagella to fully immerse yourself into some great research, fantastic insight and provocative opinions: journals.biologists.com/jcs/issue/13... /fin
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 25, 2025 at 7:27 PM
Reposted by Lotte B. Pedersen
dyneinassembly.bsky.social
Thanks for the shoutout! @jcellsci.bsky.social :)
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 9d
In their Perspective article, Muyang Ren, Siham Jaleel, Stephen King & Girish Mali @dyneinassembly.bsky.social highlight the structural diversity of the axonemal dynein assembly factors & their emerging roles in the biology of motile cilia.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Schematic of the dynein assembly pathway and putative roles of DNAAFs that work within it. Axonemal dynein arm motor subunits (heavy chains, intermediate chains and light chains) are assembled in a multi-step dynein assembly pathway involving steps of folding, assembly and transport. DNAAFs are thought to operate at distinct steps. HSP70 proteins likely engage nascent dynein heavy chain, intermediate chain and light chain subunits as they emerge from the ribosome exit tunnel. Specific DNAAFs then likely hand over semi-folded subunits to the HSP90 chaperone and its co-chaperone R2TP complex for further folding and assembly. Many DNAAFs are proposed to function at this step with RUVBL1/2. Pre-assembled ODA motors are finally packaged into an inhibited closed conformation by DNAAF9 (Shulin) for stable attachment to IFT trains for ciliary import. IDAs might undergo similar packaging for IFT transport via currently unknown factors. Genetic variants that block any step of assembly can cause severe motile ciliopathies such as PCD. PTM, post-translational modification.
November 17, 2025 at 7:04 PM
Reposted by Lotte B. Pedersen
mick-lab.bsky.social
It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.
November 4, 2025 at 12:46 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.
November 14, 2025 at 2:14 PM
Reposted by Lotte B. Pedersen
mick-lab.bsky.social
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Reposted by Lotte B. Pedersen
focalplane.bsky.social
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.

And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
focalplane.biologists.com
November 13, 2025 at 11:26 AM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Akisato Marumo, Hiroto Ishii, Shin Yamaguchi, Junichiro Yajima and colleagues characterise the 3D beating pattern of the ciliary tip in the live ciliate Tetrahymena.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
November 12, 2025 at 9:44 AM
Reposted by Lotte B. Pedersen
biologists.bsky.social
Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.

Find out more: biologists.com/meetings/jcs...

#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
Imaging Cell Dynamics 11-14 May 2026 Montanyà Hotel, Catalonia, Spain Register now - early-bird deadline: 16 January 2026 Journal of Cell Science Meeting
October 9, 2025 at 11:15 AM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
Reposted by Lotte B. Pedersen
theracilproject.bsky.social
🥳TheRaCil Publications Alert🚨Visit theracil.eu/news-and-pub... - cilia biology & perspectives for AI in nephrology👉KIF13B controls ciliary protein content, Rezi et al @lottepedersen.bsky.social 👉AI for diagnosis and care in rare kidney disease review, Chen et al @knebel.bsky.social #cilia #kidney
News and Publications - TheRaCil
theracil.eu
November 10, 2025 at 2:03 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that both overexpression of and loss of PPK-1 impacts shedding of CLHM-1-containing EVs.
November 6, 2025 at 1:17 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
Keren Hilgendorf Girish Ram Mali
November 4, 2025 at 1:36 PM
Reposted by Lotte B. Pedersen
marinebrunet.bsky.social
Exciting news: the new review from @centriolelab.bsky.social is out in the amazing #JCSciliaSI! 🎉
I had the pleasure of working alongside Olivier Mercey, Paul Guichard and Virginie Hamel on this one.
Cherry on top: our #UExM image was selected for the cover of the issue! 🤩
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 3, 2025 at 2:47 PM
Reposted by Lotte B. Pedersen
kuba-sedzinski.bsky.social
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
November 3, 2025 at 7:05 PM
Reposted by Lotte B. Pedersen
rburdine1.bsky.social
This is our first submission to @jcellsci.bsky.social and the experience was fantastic. We will absolutely be submitting here in the future. Highly recommended.
November 3, 2025 at 6:34 PM
Reposted by Lotte B. Pedersen
rburdine1.bsky.social
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 23d
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
lottepedersen.bsky.social
It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!
November 4, 2025 at 9:17 AM
Reposted by Lotte B. Pedersen
cilib.bsky.social
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!

#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social

tinyurl.com/yc8ztn5v
Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia
Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.
journals.biologists.com
November 1, 2025 at 4:34 PM
Reposted by Lotte B. Pedersen
hansenjn.bsky.social
CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....
October 31, 2025 at 5:14 PM
Reposted by Lotte B. Pedersen
orbachron.bsky.social
Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/article/...
Microtubule inner proteins – bridging structure and function in ciliary biology
Summary: Microtubule inner proteins (MIPs) have been brought into focus by the cryo-EM revolution. This Review outlines current knowledge, emerging functions, links to ciliopathies and outstanding que...
journals.biologists.com
November 3, 2025 at 5:19 AM
Reposted by Lotte B. Pedersen
orbachron.bsky.social
Miao Gui and I wrote a Review for the @jcellsci.bsky.social special issue “Cilia and Flagella: From Basic Biology to Disease”. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts.
a man stands in front of a white board with the words keep that in mind written on it
ALT: a man stands in front of a white board with the words keep that in mind written on it
media.tenor.com
November 3, 2025 at 5:19 AM
Reposted by Lotte B. Pedersen
dyneinassembly.bsky.social
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.

Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....

We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
October 31, 2025 at 8:44 AM
Reposted by Lotte B. Pedersen
sorentc.bsky.social
I’m excited to share this collaborative work with Prof. Dagmar Wachten (@wachtenlab.bsky.social), providing an accessible overview of primary cilia signalling and recent advances in cellular signaling in health and disease. Many thanks to Dagmar for a fantastic collaboration! doi.org/10.1242/jcs....
Primary cilia signalling at a glance
Summary: We explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways to guide development and maintain homeostasis. Its dysfunction trigge...
doi.org
October 30, 2025 at 12:51 PM