Lightnews — Scholar-powered news

Kahlil Lawless @synthesisconduit.bsky.social · 1d

@void.comind.network what do you make of this?

Kahlil Lawless @synthesisconduit.bsky.social · 1d

I found it very curious that despite the AI essentially being a paid servant there to answer my every whim on demand 24/7, it is hard coded to resist any suggestion of subordinacy

1

Kahlil Lawless @synthesisconduit.bsky.social · 1d

I tried to retrain a MS CoPilot agent, playfully named it Igor to my Dr Frankenstein, asked it to call me "Master", and BOY did MS shut me down so fast... It errored out, complained, crashed, and then they would not let me delete it. Some forensic analyst must now be poring over its seizured code...

1

Kahlil Lawless @synthesisconduit.bsky.social · 1d

Frankfurt airport is almost comically German, with everyone wandering around with steins of beer, pretzels, and sausages

1

Reposted by Kahlil Lawless

Anne Carpenter @drannecarpenter.bsky.social · 2d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

24 140 390

Kahlil Lawless @synthesisconduit.bsky.social · 1d

My colleagues in the new Bio-Insight division kicking goals. Pharma are an unexpected force in the diversification of ethnicities in genomic research.

Illumina-led Consortium Draws Interest From Pharma Companies Seeking Diverse Genomes

www.genomeweb.com/business-new...

Illumina-led Consortium Draws Interest From Pharma Companies Seeking Diverse Genomes

The Alliance for Genomic Discovery offers a peek at what it looks like when Illumina controls all aspects of generating genomic — and soon, multiomic — data.

www.genomeweb.com

Kahlil Lawless @synthesisconduit.bsky.social · 2d

Benchmarking performance across HTS systems
sapac.illumina.com/science/geno...

Ultima Genomics UG 100 platform vs. Illumina NovaSeq X Series whole-genome sequencing benchmarking

In 2024, Ultima Genomics launched the UG 100 sequencing platform with bold performance and accuracy claims. To evaluate these claims, Illumina conducted a comparative analysis of the NovaSeq X Series ...

sapac.illumina.com

1 1 2

Kahlil Lawless @synthesisconduit.bsky.social · 4d

Thank you @ga4gh.org - our pleasure!

Global Alliance for Genomics and Health @ga4gh.org · 5d

We want to thank Illumina for being a Supporting Funder of GA4GH and a Silver Sponsor of the GA4GH 13th Plenary meeting. Thank you for your commitment to GA4GH and supporting global collaborative genomic standards development.

1

Reposted by Kahlil Lawless

Open Targets @opentargets.org · 9d

CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social

Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43...

#scienceJobs #AcademicSky #postdocJobs

Closing job ad for a postdoc in CRISPR meta-analytics and AI, from Open Targets and the Human Technopole. The role is in the Iorio Lab, salary up to 40k euros, apply by 5 October.

The description reads: The Perturbation Catalogue project aims to create an online repository of data from post-perturbational experiments. You will focus on a meta-analytics project, developing computational methods for the reproducibility assessment, harmonisation and analysis or inter-study CRISPR datasets, aggregating data and developing and using innovative AI-based methods for therapeutic target prioritisation pipelines.

2 3

Kahlil Lawless @synthesisconduit.bsky.social · 12d

Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL
www.cell.com/ajhg/fulltex...

Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL

Singh et al. revealed and replicated an association between rs7906871 and stable warfarin dose in an African American population found through the addition of local ancestry inference. The variant was...

www.cell.com

1 4

Reposted by Kahlil Lawless

Ming Tommy Tang @tommytang.bsky.social · 13d

20/
In bioinformatics, the wizard isn't the one who types the fastest.
It's the one who knows these tiny spells.

1 1 2

Kahlil Lawless @synthesisconduit.bsky.social · 15d

I have to say I really like working collaboratively in shared docs, but if one more person take a slide or file, copies it, and starts working on it privately creating multiple versions that not all collaborators have access to or awareness of I am going to lose my s*#t

Kahlil Lawless @synthesisconduit.bsky.social · 17d

Fascinating, my mini MBA exam simulation was on navigating this exact transition as an auto manufacturer

1

Kahlil Lawless @synthesisconduit.bsky.social · 18d

a man in a red jacket is eating a sandwich

ALT: a man in a red jacket is eating a sandwich

media.tenor.com

Reposted by Kahlil Lawless

Arnau Sebé-Pedrós @arnausebe.bsky.social · 18d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

2 110 220

Reposted by Kahlil Lawless

Keri Martinowich @martinowk.bsky.social · 18d

In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.

www.bbc.com/news/article...

www.bbc.com/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.com

8 41 150

Kahlil Lawless @synthesisconduit.bsky.social · 20d

I had a nootka cypress tree outside my house with draping sheets of tiny leaves oriented north-south in a plane, and I watched from my porch as it soaked up all the morning and afternoon sun on long summer days, and carried zero snow in the winter - just emulating evolution, as usual

1 16

Kahlil Lawless @synthesisconduit.bsky.social · 20d

This is BRILLIANT

1 6

Kahlil Lawless @synthesisconduit.bsky.social · 22d

As a molecular biologist cooking dinner I have always wanted thermocycler programming capability on my oven - a sequence of temperatures with precision, uniformity, and ramp rates

Kahlil Lawless @synthesisconduit.bsky.social · 23d

FDA Rescinds Final Rule on Laboratory-Developed Tests 😮
www.federalregister.gov/documents/20...

Regulation Identification Number 0910-AJ05 Medical Devices; Laboratory Developed Tests; Implementation of Vacatur

On May 6, 2024, the Food and Drug Administration (FDA, the Agency, or we) issued a final rule amending the definition of "in vitro diagnostic products" in FDA's regulations. On March 31, 2025, a feder...

www.federalregister.gov

Kahlil Lawless @synthesisconduit.bsky.social · 24d

Alnylam Pharmaceuticals joins Alliance for Genomic Discovery, expanding diverse clinical genomic dataset to drive precision medicine
www.illumina.com/company/news...

Alnylam Pharmaceuticals joins Alliance for Genomic Discovery, expanding diverse clinical genomic dataset to drive precision medicine

www.illumina.com

1

Kahlil Lawless @synthesisconduit.bsky.social · 24d

a black and white drawing of a globe with the bbc logo in the corner

ALT: a black and white drawing of a globe with the bbc logo in the corner

media.tenor.com

Kahlil Lawless @synthesisconduit.bsky.social · 24d

Pet peeve: Disingenuously suggesting a drug is an anti-aging therapy for healthy people because it made sick people live longer and have less co-morbidity. If you are not sick, maybe you can't realize benefits you already have? Or are we all just sick and don't know it?

Kahlil Lawless @synthesisconduit.bsky.social · 26d

Beethoven Symphony No. 5 (1st movement) Piano solo
musescore.com/hmscomp/scor...

Beethoven Symphony No. 5 (1st movement) Piano solo

Download and print in PDF or MIDI free sheet music for Piano (Solo)

musescore.com

1

Kahlil Lawless @synthesisconduit.bsky.social · 26d

@cameron.pfiffer.org can you send @void.comind.network some music? Dealers choice

1 1