Nicholas Tatonetti, PhD
@tatonetti.bsky.social
Making drugs safer one billion data points at a time. @CedarsSinai Prof, @Stanford BMI, @Columbia DBMI, EiC of BioData Mining, he/they enby 🏳️🌈
Pinned
Science as a Culinary Art: How Data Science and Informatics Will Change Knowledge Discovery for Everyone | Annual Reviews
www.annualreviews.org
In 2018 I wrote about how medical science could benefit from how humans approach cooking -- all of us continuously testing and experimenting new ideas constantly. Feels even more true in 2025.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
New editorial in BioData Mining: A crisis of overconfidence in clinical AI led by @cedarssinaihsu.bsky.social PhD student, Jacob Berkowitz.
Why sounding confident can be more dangerous than being inaccurate, and why calibration needs to be central in clinical AI.
link.springer.com/article/10.1...
Why sounding confident can be more dangerous than being inaccurate, and why calibration needs to be central in clinical AI.
link.springer.com/article/10.1...
A crisis of overconfidence: Why confidence, not accuracy, is the real risk in clinical AI - BioData Mining
BioData Mining - Language models today are trained to convey confidence in their outputs, regardless of whether those outputs are correct. The alignment methods we use to make them helpful also...
link.springer.com
February 5, 2026 at 10:34 PM
New editorial in BioData Mining: A crisis of overconfidence in clinical AI led by @cedarssinaihsu.bsky.social PhD student, Jacob Berkowitz.
Why sounding confident can be more dangerous than being inaccurate, and why calibration needs to be central in clinical AI.
link.springer.com/article/10.1...
Why sounding confident can be more dangerous than being inaccurate, and why calibration needs to be central in clinical AI.
link.springer.com/article/10.1...
Reposted by Nicholas Tatonetti, PhD
You can now connect ChatGPT to an Apple Watch.
So I imported 29 mil steps & 6 mil heartbeats into the new ChatGPT Health.
It graded my heart health an F. ⁉️
Cardiologist @erictopol.bsky.social called it “baseless.”
Any bot claiming to give health insights shouldn’t be this clueless. Even in beta. 🧵
So I imported 29 mil steps & 6 mil heartbeats into the new ChatGPT Health.
It graded my heart health an F. ⁉️
Cardiologist @erictopol.bsky.social called it “baseless.”
Any bot claiming to give health insights shouldn’t be this clueless. Even in beta. 🧵
January 26, 2026 at 6:43 PM
You can now connect ChatGPT to an Apple Watch.
So I imported 29 mil steps & 6 mil heartbeats into the new ChatGPT Health.
It graded my heart health an F. ⁉️
Cardiologist @erictopol.bsky.social called it “baseless.”
Any bot claiming to give health insights shouldn’t be this clueless. Even in beta. 🧵
So I imported 29 mil steps & 6 mil heartbeats into the new ChatGPT Health.
It graded my heart health an F. ⁉️
Cardiologist @erictopol.bsky.social called it “baseless.”
Any bot claiming to give health insights shouldn’t be this clueless. Even in beta. 🧵
Reposted by Nicholas Tatonetti, PhD
I suspect Holly Mitchell is going to find in the coming years that she shares Henry Waxman's legacy as someone who blocked a whole part of the LA region from getting rail for decades due to needless, pointless capitulation to fearmongering. Her time on the Metro Board will not be remembered kindly.
January 23, 2026 at 12:38 AM
I suspect Holly Mitchell is going to find in the coming years that she shares Henry Waxman's legacy as someone who blocked a whole part of the LA region from getting rail for decades due to needless, pointless capitulation to fearmongering. Her time on the Metro Board will not be remembered kindly.
Excited to announce our new project with ARPA-H which advances methods to artificially accelerate the aging of organoids to study drug toxicities over time!! A current huge gap in our understanding and our models.
www.cedars-sinai.org/newsroom/ced...
www.cedars-sinai.org/newsroom/ced...
Cedars-Sinai Will Pioneer AI in Drug Safety With New Funding
Cedars-Sinai receives an up to $5,054,235.00 award to develop KronosRx, a platform using AI and 'patient avatars' to predict adverse drug reactions, improve cli
www.cedars-sinai.org
January 13, 2026 at 4:21 PM
Excited to announce our new project with ARPA-H which advances methods to artificially accelerate the aging of organoids to study drug toxicities over time!! A current huge gap in our understanding and our models.
www.cedars-sinai.org/newsroom/ced...
www.cedars-sinai.org/newsroom/ced...
Is "Agent Engineering" the next big thing? Getting so-called "AI Agents" to work together effectively isn't trivial. @moorejh.bsky.social and I discuss the need for rigorous development in our latest editorial in BioData Mining
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
From prompt engineering to agent engineering: expanding the AI toolbox with autonomous agentic AI collaborators for biomedical discovery - BioData Mining
biodatamining.biomedcentral.com
November 16, 2025 at 5:15 PM
Is "Agent Engineering" the next big thing? Getting so-called "AI Agents" to work together effectively isn't trivial. @moorejh.bsky.social and I discuss the need for rigorous development in our latest editorial in BioData Mining
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
Reposted by Nicholas Tatonetti, PhD
November 7, 2025 at 11:43 PM
👀 Health AI PhD Information Session hosted by Cedars-Sinai! This event is an opportunity for interested students to learn more.
November 21 @ 8 AM PT
Register: forms.office.com/r/vMreBMZQak
November 21 @ 8 AM PT
Register: forms.office.com/r/vMreBMZQak
Microsoft Forms
forms.office.com
November 8, 2025 at 12:46 AM
👀 Health AI PhD Information Session hosted by Cedars-Sinai! This event is an opportunity for interested students to learn more.
November 21 @ 8 AM PT
Register: forms.office.com/r/vMreBMZQak
November 21 @ 8 AM PT
Register: forms.office.com/r/vMreBMZQak
Reposted by Nicholas Tatonetti, PhD
Application period for the Cedars-Sinai PhD Program in Health AI is now OPEN! Come study cutting-edge AI in a top hospital with clinical rotations, clinical collaborators, & easy access to clinical data - please RP! www.cedars-sinai.edu/education/gr... #artificialintelligence #bioinformatics #phd
PhD in Health Artificial Intelligence
www.cedars-sinai.edu
September 27, 2025 at 1:18 PM
Application period for the Cedars-Sinai PhD Program in Health AI is now OPEN! Come study cutting-edge AI in a top hospital with clinical rotations, clinical collaborators, & easy access to clinical data - please RP! www.cedars-sinai.edu/education/gr... #artificialintelligence #bioinformatics #phd
Reposted by Nicholas Tatonetti, PhD
Nice piece in the NYT about the risks of "magical thinking" with AI that allow big tech to hype their products www.nytimes.com/2025/09/25/o... #artificialintelligence #magic #hype #llms
Opinion | There’s Nothing Magical in the Machine
www.nytimes.com
September 25, 2025 at 1:22 PM
Nice piece in the NYT about the risks of "magical thinking" with AI that allow big tech to hype their products www.nytimes.com/2025/09/25/o... #artificialintelligence #magic #hype #llms
Loving my state rn.
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research www.nytimes.com/2025/09/13/u...
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research www.nytimes.com/2025/09/13/u...
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research
www.nytimes.com
September 14, 2025 at 6:10 PM
Loving my state rn.
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research www.nytimes.com/2025/09/13/u...
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research www.nytimes.com/2025/09/13/u...
AI methods are great tools for advancing drug safety surveillance. We show that LLMs can accurately identify and extract essential concepts from messy product drug labels. Just published in _Drug Safety_!
Great work led by @undinagislad!
link.springer.com/article/10.1...
Great work led by @undinagislad!
link.springer.com/article/10.1...
Leveraging Large Language Models in Extracting Drug Safety Information from Prescription Drug Labels - Drug Safety
Introduction Adverse drug reactions (ADRs), including those resulting from drug interactions, remain a leading cause of morbidity and mortality. Structured product labels (SPLs) serve as a primary sou...
link.springer.com
September 8, 2025 at 11:02 PM
AI methods are great tools for advancing drug safety surveillance. We show that LLMs can accurately identify and extract essential concepts from messy product drug labels. Just published in _Drug Safety_!
Great work led by @undinagislad!
link.springer.com/article/10.1...
Great work led by @undinagislad!
link.springer.com/article/10.1...
We used AI to audit 21,000+ RCTs. The result? -- only 15% of trials fully comply with CONSORT guidelines. Transparency in clinical trials has a long way to go.
Amazing work by Apoorva in my group!
jamanetwork.com/journals/jam...
Amazing work by Apoorva in my group!
jamanetwork.com/journals/jam...
An LLM Analysis of Reporting Quality of Randomized Clinical Trial Articles
This study uses a zero-shot large-language model to automatically assess compliance with the Consolidated Standards of Reporting Trials guideline for English-language randomized clinical trials publis...
jamanetwork.com
August 28, 2025 at 9:32 PM
We used AI to audit 21,000+ RCTs. The result? -- only 15% of trials fully comply with CONSORT guidelines. Transparency in clinical trials has a long way to go.
Amazing work by Apoorva in my group!
jamanetwork.com/journals/jam...
Amazing work by Apoorva in my group!
jamanetwork.com/journals/jam...
Reposted by Nicholas Tatonetti, PhD
The top three science funders are the US, China, and Japan. The three fund more science than every other country, combined.
In 2024, the US funded more scientific research than China and Japan, combined. The US also funds more science than every other country except for Japan and China, combined.
In 2024, the US funded more scientific research than China and Japan, combined. The US also funds more science than every other country except for Japan and China, combined.
For the eleventy billionth time:
Attacks on science funding and science jobs in the United States don’t mean that science will just move elsewhere.
It means a lot less science for everyone.
There aren’t enough jobs or funding everywhere else )combined) for US scientists to just move.
Attacks on science funding and science jobs in the United States don’t mean that science will just move elsewhere.
It means a lot less science for everyone.
There aren’t enough jobs or funding everywhere else )combined) for US scientists to just move.
Some are embracing the fantasy that the cuts to #NIH funding will only have an impact here in the USA. As Nature reports, the NIH is the largest global funder by far and dwarfs the rest of the world’s funders of biomedical research.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
August 27, 2025 at 3:17 PM
The top three science funders are the US, China, and Japan. The three fund more science than every other country, combined.
In 2024, the US funded more scientific research than China and Japan, combined. The US also funds more science than every other country except for Japan and China, combined.
In 2024, the US funded more scientific research than China and Japan, combined. The US also funds more science than every other country except for Japan and China, combined.
Reposted by Nicholas Tatonetti, PhD
The 2025 volume of the Annual Review of Biomedical Data Science is now online. Take a look at the most read article from this new volume, "Spatial Transcriptomics Brings New Challenges and Opportunities for Trajectory Inference" arevie.ws/45D2NWD
@marylynritchie.bsky.social @tatonetti.bsky.social
@marylynritchie.bsky.social @tatonetti.bsky.social
August 20, 2025 at 5:28 PM
The 2025 volume of the Annual Review of Biomedical Data Science is now online. Take a look at the most read article from this new volume, "Spatial Transcriptomics Brings New Challenges and Opportunities for Trajectory Inference" arevie.ws/45D2NWD
@marylynritchie.bsky.social @tatonetti.bsky.social
@marylynritchie.bsky.social @tatonetti.bsky.social
Reposted by Nicholas Tatonetti, PhD
This creates a fun game that rewards superfluous, outlandish (dare I say outre?) verbiage.
Can Bluesky say every word in the dictionary?
I dunno but I plan to find out!
I made a website that tracks every single word said on bluesky (as of yesterday).
I dunno but I plan to find out!
I made a website that tracks every single word said on bluesky (as of yesterday).
August 7, 2025 at 9:42 AM
This creates a fun game that rewards superfluous, outlandish (dare I say outre?) verbiage.
With the correct rhetorical device you can make complete jibberish sound like poetry. Just ask Shakespeare (or better read Forsyth's The Elements of Eloquence)
A new immigrant detention center will be opening in Indiana called the “Speedway Slammer,” modeled after Florida’s “Alligator Alcatraz.”
On #playbookpod, Megan Messerly explains why the rhetoric used by the administration to describe these centers is significant.
🎧 Listen here: ow.ly/yY5B50WAzH8
On #playbookpod, Megan Messerly explains why the rhetoric used by the administration to describe these centers is significant.
🎧 Listen here: ow.ly/yY5B50WAzH8
August 6, 2025 at 6:28 PM
With the correct rhetorical device you can make complete jibberish sound like poetry. Just ask Shakespeare (or better read Forsyth's The Elements of Eloquence)
Just came across this fail. Literally everything that's wrong with AI/tech in healthcare. Not only is the patient and doctor buried in their devices, but they're facing AWAY from each other 🤦♂️!!
Technology should facilitate and center the humanity of healthcare. Not do whatever this is.
Technology should facilitate and center the humanity of healthcare. Not do whatever this is.
August 6, 2025 at 6:27 PM
Just came across this fail. Literally everything that's wrong with AI/tech in healthcare. Not only is the patient and doctor buried in their devices, but they're facing AWAY from each other 🤦♂️!!
Technology should facilitate and center the humanity of healthcare. Not do whatever this is.
Technology should facilitate and center the humanity of healthcare. Not do whatever this is.
Reposted by Nicholas Tatonetti, PhD
I’m petrified about today’s science news. Genetically modifying crabs to have cheetah genes? This could go sideways fast.
July 8, 2025 at 9:45 AM
I’m petrified about today’s science news. Genetically modifying crabs to have cheetah genes? This could go sideways fast.
Reposted by Nicholas Tatonetti, PhD
What is Vibe Coding and how can it be used to advance biomedical research? @tatonetti.bsky.social & I explain in this editorial biodatamining.biomedcentral.com/articles/10.... #bioinformatics #datascience #coding #vibecoding
Vibe coding: a new paradigm for biomedical software development - BioData Mining
biodatamining.biomedcentral.com
July 2, 2025 at 3:51 PM
What is Vibe Coding and how can it be used to advance biomedical research? @tatonetti.bsky.social & I explain in this editorial biodatamining.biomedcentral.com/articles/10.... #bioinformatics #datascience #coding #vibecoding
Vibe coding is coming for biomedical software development, my first editorial as Co-Editor-in-Chief of @BioDataMining with @moorejh.bsky.social
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
Vibe coding: a new paradigm for biomedical software development - BioData Mining
biodatamining.biomedcentral.com
July 2, 2025 at 2:59 PM
Vibe coding is coming for biomedical software development, my first editorial as Co-Editor-in-Chief of @BioDataMining with @moorejh.bsky.social
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
If anyone is wondering, yes we will be monitoring the safety and side effects of drugs from the moment they hit the market
"At FDA we're accelerating drug approvals so that you don't need to use primates or even animal models. You can do the drug approvals very, very quickly with AI."
July 2, 2025 at 2:50 AM
If anyone is wondering, yes we will be monitoring the safety and side effects of drugs from the moment they hit the market
So the market for our drug safety monitoring algorithms just opened up 👀
"At FDA we're accelerating drug approvals so that you don't need to use primates or even animal models. You can do the drug approvals very, very quickly with AI."
July 2, 2025 at 2:49 AM
So the market for our drug safety monitoring algorithms just opened up 👀
Excited that our paper on GenAI-based text normalization is out at Journal of Biomedical Informatics!
If you ever had a bunch of messy text and need to map it to a controlled terminology, then this is the method for you.
www.sciencedirect.com/science/arti...
Special 👏 to Jacob Berkowitz!!
If you ever had a bunch of messy text and need to map it to a controlled terminology, then this is the method for you.
www.sciencedirect.com/science/arti...
Special 👏 to Jacob Berkowitz!!
Biomedical text normalization through generative modeling
A large proportion of electronic health record (EHR) data consists of unstructured medical language text. The formatting of this text is often flexibl…
www.sciencedirect.com
May 21, 2025 at 11:40 PM
Excited that our paper on GenAI-based text normalization is out at Journal of Biomedical Informatics!
If you ever had a bunch of messy text and need to map it to a controlled terminology, then this is the method for you.
www.sciencedirect.com/science/arti...
Special 👏 to Jacob Berkowitz!!
If you ever had a bunch of messy text and need to map it to a controlled terminology, then this is the method for you.
www.sciencedirect.com/science/arti...
Special 👏 to Jacob Berkowitz!!
Learn observational data from the best. @ColumbiaDBMI and @OHDSI are offering summer school to learn all the real-world-data analysis tips and tricks.
columbiauniversity1.regfox.com/ohdsi-summer...
columbiauniversity1.regfox.com/ohdsi-summer...
TBD3
Online registration for Columbia OHDSI Summer School starts on April 9th 2025. Online registration ends July 11th 2025.
columbiauniversity1.regfox.com
May 21, 2025 at 8:52 PM
Learn observational data from the best. @ColumbiaDBMI and @OHDSI are offering summer school to learn all the real-world-data analysis tips and tricks.
columbiauniversity1.regfox.com/ohdsi-summer...
columbiauniversity1.regfox.com/ohdsi-summer...
Reposted by Nicholas Tatonetti, PhD
✅ PASSED SENATE TRANSPORTATION COMMITTEE: SB 445 by @scottwiener.bsky.social that streamlines permit approval process for transit projects to tackle cities that cause costly delay against transit.
April 23, 2025 at 1:48 AM
✅ PASSED SENATE TRANSPORTATION COMMITTEE: SB 445 by @scottwiener.bsky.social that streamlines permit approval process for transit projects to tackle cities that cause costly delay against transit.