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The Cousin Lab @thecousinlab.bsky.social · Jun 27

Huge thanks to @hantan98.bsky.social for completing the work started by Andrew and Robyn many moons ago!! Many thanks also to CHDI for funding!

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The Cousin Lab @thecousinlab.bsky.social · Jun 27

Excess ADBE was conserved across all cell types examined and intriguingly was due to huntingtin haploinsufficiency, rather than a toxic gain of function of mutant huntingtin.

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The Cousin Lab @thecousinlab.bsky.social · Jun 27

• We are delighted to contribute to this work just out in @jneurochem.bsky.social, where we collaborate with the BlueSkyless Smillie lab to reveal that Huntington’s Disease model neurons display excess activity-dependent bulk endocytosis (ADBE).

onlinelibrary.wiley.com

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Reposted by The Cousin Lab

International Society for Neurochemistry @neurochemistry.org · Jun 26

ISN is seeking volunteers for its committees!

This is a great opportunity to contribute, connect, and help lead our global community.

🗓️ Apply by June 29
📨 Email: [email protected] with a short bio and brief statement on why you’re applying.

#WeAreNeurochemistry #neurosky

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The Cousin Lab @thecousinlab.bsky.social · May 25

Fantastic effort from the Presynaptic Pacers, covering the slow leg from an old PI in their team at the Hairy Haggis relay!! All done to support @epilepsyinst.bsky.social!

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The Cousin Lab @thecousinlab.bsky.social · May 16

Huge thanks to James, Jess, Zita and Angus for manning the @mmecepilepsy.bsky.social table today at the CDBS friends and family day! Great to spread the word about the amazing work the Centre is doing!

The Cousin Lab @thecousinlab.bsky.social · May 8

Great work Sam!!

Reposted by The Cousin Lab

sambooker.bsky.social @sambooker.bsky.social · May 7

What, what! We just published our work studying GABAB receptors in human and rat brain.

www.nature.com/articles/s41...

Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications

GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...

www.nature.com

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The Cousin Lab @thecousinlab.bsky.social · May 5

All funds raised go to @epilepsyinst.bsky.social !!

The Cousin Lab @thecousinlab.bsky.social · May 5

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

2025 Hairy Haggis Marathon for Epilepsy Research Institute UK

Help Han Tan raise money to support Epilepsy Research Institute UK

shorturl.at

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Reposted by The Cousin Lab

The Cousin Lab @thecousinlab.bsky.social · May 5

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

2025 Hairy Haggis Marathon for Epilepsy Research Institute UK

Help Han Tan raise money to support Epilepsy Research Institute UK

shorturl.at

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The Cousin Lab @thecousinlab.bsky.social · May 5

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

2025 Hairy Haggis Marathon for Epilepsy Research Institute UK

Help Han Tan raise money to support Epilepsy Research Institute UK

shorturl.at

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Reposted by The Cousin Lab

Eugenio F. Fornasiero @forna.bsky.social · Apr 22

Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...

Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models.

Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...

www.biorxiv.org

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The Cousin Lab @thecousinlab.bsky.social · Apr 17

This would not have been possible without the heroic effort of Dr. Katherine Bonnycastle who invested years in this long-term project! Thanks also to Sarfaraz for the blots!

The Cousin Lab @thecousinlab.bsky.social · Apr 17

These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.

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The Cousin Lab @thecousinlab.bsky.social · Apr 17

These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.

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The Cousin Lab @thecousinlab.bsky.social · Apr 17

Our latest paper is out in Molecular Autism! We reveal that in neurons from five independent rat models of monogenic Autism Spectrum Disorder (ASD), activity-dependent endocytosis (ADBE) is selectively depressed, with no other synaptic vesicle recycling phenotype. Link to paper - rdcu.be/eh4Qa

Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder

rdcu.be

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Reposted by The Cousin Lab

Journal of Neurochemistry @jneurochem.bsky.social · Apr 15

🎉 Congrats to Sabrin Haddad - winner of the 2024 JNC Young Scientist Paper of the Year Award (in honor of Mark A. Smith)!

Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy.

🔗Read here: bit.ly/3EjpeXq

#WeAreNeurochemistry #YoungScientistAward

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Reposted by The Cousin Lab

Cathy Abbott @cathyabbott.bsky.social · Mar 26

No sign of the aurora but at least I got to see the castle lit in purple for #epilepsy #PurpleDay ❤️

Edinburgh castle in the distance all lit up in purple

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Reposted by The Cousin Lab

Edinburgh Neuroscience @edinunineuro.bsky.social · Mar 26

It's #PurpleDay: a day to increase awareness of #epilepsy. Hannah, a 1st year PhD @edinuni-irr.bsky.social, has written about the need to investigate the neurodevelopmental consequences of early-onset epilepsy and risk factors contributing to them: edin.ac/4j6PMKh

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The Cousin Lab @thecousinlab.bsky.social · Mar 26

Happy Purple Day from us to the whole epilepsy community 💜! #PurpleDay2025

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Reposted by The Cousin Lab

International Society for Neurochemistry @neurochemistry.org · Mar 18

Job Opportunity at JNC!✍️

The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.

✅ Remote & flexible
✅ Support publishing
✅ Global network

🔗Apply here: bit.ly/3FAs1M6

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Reposted by The Cousin Lab

Marco A. Maximo Prado @maximoprado.bsky.social · Feb 5

We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.

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Reposted by The Cousin Lab

Muir Maxwell Epilepsy Centre @mmecepilepsy.bsky.social · Feb 7

Come and join our @epilepsyinst.bsky.social Doctoral Training Centre. Are you bright and passionate about epilepsy research? Want to join a nurturing and exciting programme? We have space for one more exceptional student. For details see www.muirmaxwellcentre.com/doctoral-tra...

Research Projects

www.muirmaxwellcentre.com

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Reposted by The Cousin Lab

Club Exo Endo @clubexo-endo.bsky.social · Feb 6

We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !

Club Exo Endo - Exocytose Endocytose

Le Club Exocytose-Endocytose est une association à but non lucratif, sans financement ni cotisation. Il rassemble près de 340 chercheurs, enseignants ou étudiants travaillant dans des domaines variés ...

exoendo.org

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Reposted by The Cousin Lab

Simons Initiative for the Developing Brain (SIDB) @sidb-edinburgh.bsky.social · Feb 6

The Donlin-Asp Lab ( @pdaphd.bsky.social ) is hiring a postdoc to conduct primary research into how neurons transport mRNA to distal sites and use these mRNAs as substrates for local protein synthesis during synaptic plasticity.
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

@edinunineuro.bsky.social

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The Cousin Lab @thecousinlab.bsky.social · Jan 28

New review out from our lab on SV2A! Thanks to James for all his hard work on this!

Journal of Neurochemistry @jneurochem.bsky.social · Jan 28

New in #JNC: A review article from @thecousinlab.bsky.social 📄

"SV2A is an enigmatic presynaptic protein. We discuss its key role in trafficking Synaptotagmin-1, how this controls neurotransmitter release, and how its dysfunction may result in epilepsy."

👉 bit.ly/3PUKcOE

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