Cathy Abbott
@cathyabbott.bsky.social
Professor, eEF1A2/neurological disorders. Mostly talks about research, EDI (tries hard to be a good ally) but sometimes veers off into crafts and photos of Scotland. She/her, views own.
This looks fantastic, looking forward to delving more into the predictions for EEF1A2 (where we are currently at >60 almost exclusively missense mutations!)
November 24, 2025 at 3:13 PM
This looks fantastic, looking forward to delving more into the predictions for EEF1A2 (where we are currently at >60 almost exclusively missense mutations!)
Reposted by Cathy Abbott
popEVE is out in Nature Genetics! π
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 24, 2025 at 1:35 PM
popEVE is out in Nature Genetics! π
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Ha, thank you π But yes, there must have been an explosion of new builds at some point years ago!
November 24, 2025 at 1:38 PM
Ha, thank you π But yes, there must have been an explosion of new builds at some point years ago!
I have been on this earth for a very long time but this is the first time I have seen an unfinished pylon. I guess it should be obvious they have to be constructed by someone but I am quite awestruck nevertheless
November 24, 2025 at 1:32 PM
I have been on this earth for a very long time but this is the first time I have seen an unfinished pylon. I guess it should be obvious they have to be constructed by someone but I am quite awestruck nevertheless
Reposted by Cathy Abbott
π΅βπ« soon the journals will require physical proof of the blot/gel/etc. Thinking about it, we might as well go back to mailing a physical copy of the typed manuscript and photos/negatives.
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
November 21, 2025 at 1:42 PM
π΅βπ« soon the journals will require physical proof of the blot/gel/etc. Thinking about it, we might as well go back to mailing a physical copy of the typed manuscript and photos/negatives.
Ha π Honestly, even though I never use it, I find myself editing out adjectives and any hint of floweriness in case anyone thinks I did!
November 21, 2025 at 12:32 PM
Ha π Honestly, even though I never use it, I find myself editing out adjectives and any hint of floweriness in case anyone thinks I did!
Yes, exactly- they're terrified of alienating students or putting people off applying (as though that's actually doing them any favours in the long term).
November 21, 2025 at 12:24 PM
Yes, exactly- they're terrified of alienating students or putting people off applying (as though that's actually doing them any favours in the long term).
We're sleepwalking into complete disaster here. I can't believe how quickly it's taken over, and how many students have become completely reliant on it. It's terrifying.
November 21, 2025 at 12:10 PM
We're sleepwalking into complete disaster here. I can't believe how quickly it's taken over, and how many students have become completely reliant on it. It's terrifying.
Reposted by Cathy Abbott
ππΌππΎππ»ππΏππ½An opportunity for a PhD studentship in my lab to investigate the mechanisms that mediate the specialization astrocyte endfeet (subcellular compartments enwrapping the vasculature) in collaboration with the magnificent Lorena Arancibia.
See below:
See below:
November 19, 2025 at 10:17 PM
ππΌππΎππ»ππΏππ½An opportunity for a PhD studentship in my lab to investigate the mechanisms that mediate the specialization astrocyte endfeet (subcellular compartments enwrapping the vasculature) in collaboration with the magnificent Lorena Arancibia.
See below:
See below:
Reposted by Cathy Abbott
Should you find yourself - for whatever reason - looking for a new set of authoritative, accessible summaries of the risks and benefits of vaccines to share with people, the NHS website is still doing a good job at this www.nhs.uk/vaccinations...
November 20, 2025 at 12:39 PM
Should you find yourself - for whatever reason - looking for a new set of authoritative, accessible summaries of the risks and benefits of vaccines to share with people, the NHS website is still doing a good job at this www.nhs.uk/vaccinations...
Reposted by Cathy Abbott
Superstar @sorayam.bsky.social πππππ
π¨Meet the latest early career researchers awarded Race Against Dementia Fellowshipsπ¨
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
November 20, 2025 at 11:00 AM
Superstar @sorayam.bsky.social πππππ
Reposted by Cathy Abbott
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 13, 2025 at 4:10 PM
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Reposted by Cathy Abbott
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a Β£15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
NC3Rs grant holders receive funding in MRC call
Β£15.9M awarded to develop human in vitro models of complex disease.
nc3rs.org.uk
November 12, 2025 at 10:37 AM
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a Β£15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
Less horrifically, but tellingly, the only time I met him he said (in response to something Peter Goodfellow said) β well, I've never really had a collaboratorβ π€―
November 9, 2025 at 7:51 PM
Less horrifically, but tellingly, the only time I met him he said (in response to something Peter Goodfellow said) β well, I've never really had a collaboratorβ π€―
Reposted by Cathy Abbott
November 9, 2025 at 2:32 AM
Reposted by Cathy Abbott
"The UK cannot become a science superpower unless it exploits the full range of talent that we have" - @nramnani.bsky.social
We are now welcoming applications to our BNA Scholars Programme.
π Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
We are now welcoming applications to our BNA Scholars Programme.
π Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
November 7, 2025 at 9:09 AM
"The UK cannot become a science superpower unless it exploits the full range of talent that we have" - @nramnani.bsky.social
We are now welcoming applications to our BNA Scholars Programme.
π Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
We are now welcoming applications to our BNA Scholars Programme.
π Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
Reposted by Cathy Abbott
Join us for our annual lecture! We have a fantastic line-up this year: a consultant neurosurgeon and two discovery scientists will discuss how they are redefining biomedical methods - using living human brain tissue - bringing us closer to curing major neurological diseases.
Book: edin.ac/4oYHTtk
Book: edin.ac/4oYHTtk
Edinburgh Neuroscience Public Christmas Lecture 2025
A brain surgeon and two discovery scientists unwrap the story of their unique collaboration using living human brain slices.
edin.ac
November 7, 2025 at 11:23 AM
Join us for our annual lecture! We have a fantastic line-up this year: a consultant neurosurgeon and two discovery scientists will discuss how they are redefining biomedical methods - using living human brain tissue - bringing us closer to curing major neurological diseases.
Book: edin.ac/4oYHTtk
Book: edin.ac/4oYHTtk
*So* looking forward to Celebrity Traitors tonight.
This quote from the Guardian has been making me laugh for hours now βDavid Olusogaβs β¦ so consistently misguided that you actually began to retrospectively doubt the veracity of his highly regarded documentariesβ πππ
This quote from the Guardian has been making me laugh for hours now βDavid Olusogaβs β¦ so consistently misguided that you actually began to retrospectively doubt the veracity of his highly regarded documentariesβ πππ
November 6, 2025 at 9:02 AM
*So* looking forward to Celebrity Traitors tonight.
This quote from the Guardian has been making me laugh for hours now βDavid Olusogaβs β¦ so consistently misguided that you actually began to retrospectively doubt the veracity of his highly regarded documentariesβ πππ
This quote from the Guardian has been making me laugh for hours now βDavid Olusogaβs β¦ so consistently misguided that you actually began to retrospectively doubt the veracity of his highly regarded documentariesβ πππ
Oh. A familiar but awful situation. Keeping everything crossed for you!
November 5, 2025 at 9:57 PM
Oh. A familiar but awful situation. Keeping everything crossed for you!
I'm so sorry to hear that Izzy. If anyone can keep it from happening to others in future, it's you β€οΈ
November 5, 2025 at 12:41 PM
I'm so sorry to hear that Izzy. If anyone can keep it from happening to others in future, it's you β€οΈ
Reposted by Cathy Abbott
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Oh spot on! Great article.
November 4, 2025 at 1:57 PM
Oh spot on! Great article.
Reposted by Cathy Abbott
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
network.febs.org/posts/thinki...
Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
network.febs.org
November 4, 2025 at 11:21 AM
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.
network.febs.org/posts/thinki...
network.febs.org/posts/thinki...
However long I live here I will never get used to how utterly beautiful the views from Princes St are. This was last night π
November 2, 2025 at 9:59 AM
However long I live here I will never get used to how utterly beautiful the views from Princes St are. This was last night π