Tim Nicholson
@timnicholson.bsky.social
Neuropsychiatrist, King’s College London
Reposted by Tim Nicholson
Check out my newest Substack column on bending the cause of Parkinson's disease through improved sleep.
Spoiler alert: your brain's 'glymphatic system' is more than just plumbing.
michaelokun.substack.com/p/can-we-ben...
Spoiler alert: your brain's 'glymphatic system' is more than just plumbing.
michaelokun.substack.com/p/can-we-ben...
January 19, 2026 at 2:59 PM
Check out my newest Substack column on bending the cause of Parkinson's disease through improved sleep.
Spoiler alert: your brain's 'glymphatic system' is more than just plumbing.
michaelokun.substack.com/p/can-we-ben...
Spoiler alert: your brain's 'glymphatic system' is more than just plumbing.
michaelokun.substack.com/p/can-we-ben...
Reposted by Tim Nicholson
Paper accepted! 😊 "Reframing the Free Will Debate: The Universe is Not Deterministic" will appear in Synthese. Final version available here: arxiv.org/abs/2503.19672 - with Henry Potter and George Ellis
January 15, 2026 at 7:52 AM
Paper accepted! 😊 "Reframing the Free Will Debate: The Universe is Not Deterministic" will appear in Synthese. Final version available here: arxiv.org/abs/2503.19672 - with Henry Potter and George Ellis
Reposted by Tim Nicholson
A great present for all life scientists but especially those with an interest in the brain.
Cheaper than a box of chocolates and better for you. Any royalties go to Parkinson’s research
#Neurologicalbirdsong
Murmuration amzn.eu/d/9zbsdOh
Cheaper than a box of chocolates and better for you. Any royalties go to Parkinson’s research
#Neurologicalbirdsong
Murmuration amzn.eu/d/9zbsdOh
amzn.eu
January 15, 2026 at 9:50 PM
A great present for all life scientists but especially those with an interest in the brain.
Cheaper than a box of chocolates and better for you. Any royalties go to Parkinson’s research
#Neurologicalbirdsong
Murmuration amzn.eu/d/9zbsdOh
Cheaper than a box of chocolates and better for you. Any royalties go to Parkinson’s research
#Neurologicalbirdsong
Murmuration amzn.eu/d/9zbsdOh
Reposted by Tim Nicholson
Oh, oh my. I need to go through this closely, and as noted earlier NN has a history. But my first read is wow www.nature.com/articles/s41...
Investigating the methodological foundation of lesion network mapping - Nature Neuroscience
The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.
www.nature.com
January 16, 2026 at 3:08 AM
Oh, oh my. I need to go through this closely, and as noted earlier NN has a history. But my first read is wow www.nature.com/articles/s41...
Not many moments have felt like big steps in my kids’ generally gradual development, but this is one.
Last ever bottle of Calpol (paracetamol = acetaminophen) going into recycling now youngest can swallow tablets
Along with quivers of syringes, an ever present from infancy in all parents lives!😆
Last ever bottle of Calpol (paracetamol = acetaminophen) going into recycling now youngest can swallow tablets
Along with quivers of syringes, an ever present from infancy in all parents lives!😆
December 30, 2025 at 6:18 PM
Not many moments have felt like big steps in my kids’ generally gradual development, but this is one.
Last ever bottle of Calpol (paracetamol = acetaminophen) going into recycling now youngest can swallow tablets
Along with quivers of syringes, an ever present from infancy in all parents lives!😆
Last ever bottle of Calpol (paracetamol = acetaminophen) going into recycling now youngest can swallow tablets
Along with quivers of syringes, an ever present from infancy in all parents lives!😆
Reposted by Tim Nicholson
Long-Term Tofersen: Could targeting SOD1 change ALS trajectory? Spoiler alert: YES. Miller and colleagues describe in a new paper in JAMA Neurology the long-term outcomes of Tofersen in SOD1 amyotrophic lateral sclerosis, integrating the VALOR trial and its open-label extension.
December 30, 2025 at 1:34 PM
Long-Term Tofersen: Could targeting SOD1 change ALS trajectory? Spoiler alert: YES. Miller and colleagues describe in a new paper in JAMA Neurology the long-term outcomes of Tofersen in SOD1 amyotrophic lateral sclerosis, integrating the VALOR trial and its open-label extension.
Reposted by Tim Nicholson
Non-invasive brain stimulation is stepping up to be part of future neurology. Rektorová and colleagues describe in a new paper in Nature Reviews Neurology how non-invasive brain stimulation is being used today, and where it may be headed. @parkinsondotorg.bsky.social @brainstimulation.bsky.social
December 26, 2025 at 1:23 PM
Non-invasive brain stimulation is stepping up to be part of future neurology. Rektorová and colleagues describe in a new paper in Nature Reviews Neurology how non-invasive brain stimulation is being used today, and where it may be headed. @parkinsondotorg.bsky.social @brainstimulation.bsky.social
Reposted by Tim Nicholson
Does COVID-19 increase the risk of FND?
Find out in our paper, now published in the @europeanjournalofneurology.ean.org
onlinelibrary.wiley.com/doi/10.1111/...
Using EHR data from >2.7 million COVID-19 cases, we estimated the risk of new-onset FND within six months following infection.
Find out in our paper, now published in the @europeanjournalofneurology.ean.org
onlinelibrary.wiley.com/doi/10.1111/...
Using EHR data from >2.7 million COVID-19 cases, we estimated the risk of new-onset FND within six months following infection.
Functional Neurological Disorder Following COVID‐19: Results From a Large International Electronic Health Record Database
Compared with other respiratory tract infections, the incidence of functional neurological disorder following COVID-19 is increased, with the risk higher in individuals with a more severe disease cou...
onlinelibrary.wiley.com
December 23, 2025 at 10:14 PM
Does COVID-19 increase the risk of FND?
Find out in our paper, now published in the @europeanjournalofneurology.ean.org
onlinelibrary.wiley.com/doi/10.1111/...
Using EHR data from >2.7 million COVID-19 cases, we estimated the risk of new-onset FND within six months following infection.
Find out in our paper, now published in the @europeanjournalofneurology.ean.org
onlinelibrary.wiley.com/doi/10.1111/...
Using EHR data from >2.7 million COVID-19 cases, we estimated the risk of new-onset FND within six months following infection.
Reposted by Tim Nicholson
Reclaiming FND for Rehabilitation Medicine – new open access editorial
Neurorehab colleague Phil Milburn-McNulty and I set out why Rehab Medicine is so well-suited to treating FND, why they historically haven’t and what can be done to change things.
journals.sagepub.com/doi/10.1177/...
Neurorehab colleague Phil Milburn-McNulty and I set out why Rehab Medicine is so well-suited to treating FND, why they historically haven’t and what can be done to change things.
journals.sagepub.com/doi/10.1177/...
December 23, 2025 at 10:59 AM
Reclaiming FND for Rehabilitation Medicine – new open access editorial
Neurorehab colleague Phil Milburn-McNulty and I set out why Rehab Medicine is so well-suited to treating FND, why they historically haven’t and what can be done to change things.
journals.sagepub.com/doi/10.1177/...
Neurorehab colleague Phil Milburn-McNulty and I set out why Rehab Medicine is so well-suited to treating FND, why they historically haven’t and what can be done to change things.
journals.sagepub.com/doi/10.1177/...
Such a superb, insightful & brave paper from @gailfdavies.bsky.social who so eloquently captures and describes what many of us have noticed about the evolution of symptoms as a result of patients’ interactions with the medical system👏👏💪🏻💪🏻
Straight into my top 10 of best papers ever on FND👌👌
Straight into my top 10 of best papers ever on FND👌👌
New paper outlining a spatial account of #FND and proposing an approach to the co-production of functional symptoms. It draws on my longstanding work on geographies of health knowledges, my recent health experiences, and emerging interdisciplinary conversations www.tandfonline.com/doi/full/10....
December 22, 2025 at 9:45 PM
Such a superb, insightful & brave paper from @gailfdavies.bsky.social who so eloquently captures and describes what many of us have noticed about the evolution of symptoms as a result of patients’ interactions with the medical system👏👏💪🏻💪🏻
Straight into my top 10 of best papers ever on FND👌👌
Straight into my top 10 of best papers ever on FND👌👌
Reposted by Tim Nicholson
Got my ticket for FNDS 2026! 😎
Join us in Baltimore!
Learn about FND and the mysteries of the brain!
Hang out with fun people!
Eat excellent seafood!
Allow me to regale you with tales of what was up in Fells Point before it got swanky!
etc
www.fndsociety.org/biennial-mee...
Join us in Baltimore!
Learn about FND and the mysteries of the brain!
Hang out with fun people!
Eat excellent seafood!
Allow me to regale you with tales of what was up in Fells Point before it got swanky!
etc
www.fndsociety.org/biennial-mee...
2026 Conference | FNDS
www.fndsociety.org
December 21, 2025 at 5:59 PM
Got my ticket for FNDS 2026! 😎
Join us in Baltimore!
Learn about FND and the mysteries of the brain!
Hang out with fun people!
Eat excellent seafood!
Allow me to regale you with tales of what was up in Fells Point before it got swanky!
etc
www.fndsociety.org/biennial-mee...
Join us in Baltimore!
Learn about FND and the mysteries of the brain!
Hang out with fun people!
Eat excellent seafood!
Allow me to regale you with tales of what was up in Fells Point before it got swanky!
etc
www.fndsociety.org/biennial-mee...
Amazing work led by the superb Rok ‘Rock star’ Berlot! 👏👏💪🏻💪🏻👌👌
Excited to share our new paper in @eclinicalmed.bsky.social:
www.thelancet.com/journals/ecl...
In this retrospective cohort study, we examined 147,595 individuals with FND. We investigated the prevalence of adverse life events nd psychosocial stressors, and how these relate to FND presentations.
www.thelancet.com/journals/ecl...
In this retrospective cohort study, we examined 147,595 individuals with FND. We investigated the prevalence of adverse life events nd psychosocial stressors, and how these relate to FND presentations.
Adverse life events and psychosocial stressors in functional neurological disorder: a retrospective cohort and case–control study using a large international electronic health record database
A record of adversities was at least 2·5 times more common in FND than in migraine,
and about 1·5 times more common than in GAD, varying by stressor type. Psychosocial
stressors were particularly comm...
www.thelancet.com
December 8, 2025 at 11:10 PM
Amazing work led by the superb Rok ‘Rock star’ Berlot! 👏👏💪🏻💪🏻👌👌
Reposted by Tim Nicholson
Grateful to share this work with my amazing coauthors:
@timnicholson.bsky.social, @liviaasan.bsky.social, @bibastanton.bsky.social, Tom Pollak and Mark Edwards (@kingsioppn.bsky.social, University Hospital Essen and University of Ljubljana).
#fnd, #neurology, #psychiatry, #neuropsychiatry
@timnicholson.bsky.social, @liviaasan.bsky.social, @bibastanton.bsky.social, Tom Pollak and Mark Edwards (@kingsioppn.bsky.social, University Hospital Essen and University of Ljubljana).
#fnd, #neurology, #psychiatry, #neuropsychiatry
December 7, 2025 at 9:31 PM
Grateful to share this work with my amazing coauthors:
@timnicholson.bsky.social, @liviaasan.bsky.social, @bibastanton.bsky.social, Tom Pollak and Mark Edwards (@kingsioppn.bsky.social, University Hospital Essen and University of Ljubljana).
#fnd, #neurology, #psychiatry, #neuropsychiatry
@timnicholson.bsky.social, @liviaasan.bsky.social, @bibastanton.bsky.social, Tom Pollak and Mark Edwards (@kingsioppn.bsky.social, University Hospital Essen and University of Ljubljana).
#fnd, #neurology, #psychiatry, #neuropsychiatry
📣Special @kingsioppn.bsky.social
Neuropsych talk *this Friday 5th evening 5-6pm GMT* @ki.se ‘s Jakob Theorell on ‘clinical borderlands between dementia, catatonia & autoimmune encephalitis’👌
Teams link below & all welcome to join/share share with anyone interested!👍
www.kcl.ac.uk/events/the-c...
Neuropsych talk *this Friday 5th evening 5-6pm GMT* @ki.se ‘s Jakob Theorell on ‘clinical borderlands between dementia, catatonia & autoimmune encephalitis’👌
Teams link below & all welcome to join/share share with anyone interested!👍
www.kcl.ac.uk/events/the-c...
The clinical borderlands between dementia, catatonia and autoimmune encephalitis | King's College London
Neuropsychiatry Meetings discuss exciting research and interesting cases relevant to neuropsychiatry and to promote cross-talk between psychiatry, neurology and psychology.
www.kcl.ac.uk
December 3, 2025 at 9:09 AM
📣Special @kingsioppn.bsky.social
Neuropsych talk *this Friday 5th evening 5-6pm GMT* @ki.se ‘s Jakob Theorell on ‘clinical borderlands between dementia, catatonia & autoimmune encephalitis’👌
Teams link below & all welcome to join/share share with anyone interested!👍
www.kcl.ac.uk/events/the-c...
Neuropsych talk *this Friday 5th evening 5-6pm GMT* @ki.se ‘s Jakob Theorell on ‘clinical borderlands between dementia, catatonia & autoimmune encephalitis’👌
Teams link below & all welcome to join/share share with anyone interested!👍
www.kcl.ac.uk/events/the-c...
Reposted by Tim Nicholson
Excellent podcast by #DaraAlbert & #JeffRatliffe on a recent @greenjournal.bsky.social Education article.
Targeting Self-Described Knowledge Gaps to Improve FND Education among Clinicians. Check it out.
www.neurology.org/doi/10.1212/...
neurology.libsyn.com/website/targ...
Targeting Self-Described Knowledge Gaps to Improve FND Education among Clinicians. Check it out.
www.neurology.org/doi/10.1212/...
neurology.libsyn.com/website/targ...
Education Research: Targeting Self-Described Knowledge Gaps to Improve Functional Neurologic Disorder Education Among Clinicians | Neurology Education
Background and ObjectivesThe objective of this study was to improve functional neurologic disorder (FND) education
by identifying knowledge gaps among providers who registered for an online course
on ...
www.neurology.org
December 2, 2025 at 2:09 PM
Excellent podcast by #DaraAlbert & #JeffRatliffe on a recent @greenjournal.bsky.social Education article.
Targeting Self-Described Knowledge Gaps to Improve FND Education among Clinicians. Check it out.
www.neurology.org/doi/10.1212/...
neurology.libsyn.com/website/targ...
Targeting Self-Described Knowledge Gaps to Improve FND Education among Clinicians. Check it out.
www.neurology.org/doi/10.1212/...
neurology.libsyn.com/website/targ...
Reposted by Tim Nicholson
Thanks for the post @alancarson15.bsky.social - grateful that the Harvard Medical School magazine put together this spotlight on functional neurological disorder.
November 22, 2025 at 8:14 PM
Thanks for the post @alancarson15.bsky.social - grateful that the Harvard Medical School magazine put together this spotlight on functional neurological disorder.
Reposted by Tim Nicholson
What an incredible piece of work. So cool to read about Charcot in this vivid detail - who had such a huge effect on FND, but also ... most other neurological conditions you've heard of. And the fields of neurology and psychology. And popular culture. And...
"Charcot Redux" - @ajlees.bsky.social has written a magisterial article on Charcot, which gives you something of the man and his context.
Essential for anyone needing an introduction
doi.org/10.1093/brai...
Essential for anyone needing an introduction
doi.org/10.1093/brai...
November 25, 2025 at 1:32 PM
What an incredible piece of work. So cool to read about Charcot in this vivid detail - who had such a huge effect on FND, but also ... most other neurological conditions you've heard of. And the fields of neurology and psychology. And popular culture. And...
Reposted by Tim Nicholson
🎙️ New podcast episode!
We’re joined by Dr. Sarah Cope, Consultant Clinical Psychologist & accredited EMDR/CBT therapist.
We cover:
• Her path into FND
• EMDR basics
• EMDR for FND, incl. her NIHR-funded MODIFI trial
We’re joined by Dr. Sarah Cope, Consultant Clinical Psychologist & accredited EMDR/CBT therapist.
We cover:
• Her path into FND
• EMDR basics
• EMDR for FND, incl. her NIHR-funded MODIFI trial
November 24, 2025 at 11:22 PM
🎙️ New podcast episode!
We’re joined by Dr. Sarah Cope, Consultant Clinical Psychologist & accredited EMDR/CBT therapist.
We cover:
• Her path into FND
• EMDR basics
• EMDR for FND, incl. her NIHR-funded MODIFI trial
We’re joined by Dr. Sarah Cope, Consultant Clinical Psychologist & accredited EMDR/CBT therapist.
We cover:
• Her path into FND
• EMDR basics
• EMDR for FND, incl. her NIHR-funded MODIFI trial
Still a few tickets left for this event with the amazing @mikejay.bsky.social tonight 6-7.30 at @kingsioppn.bsky.social
All welcome as Mike discusses his new book on the discovery of N2O & the birth of psychedelic science👌👌
All welcome as Mike discusses his new book on the discovery of N2O & the birth of psychedelic science👌👌
Do you know the history behind the discovery of laughing gas?
Join @mikejay.bsky.social, historian of science and medicine as he discusses his latest book, Free Radicals.
21/11, 6pm Wolfson Lecture Theatre, SE5 8AB
Tickets: www.kcl.ac.uk/events/free-...
Join @mikejay.bsky.social, historian of science and medicine as he discusses his latest book, Free Radicals.
21/11, 6pm Wolfson Lecture Theatre, SE5 8AB
Tickets: www.kcl.ac.uk/events/free-...
Free Radicals - In conversation with Mike Jay | King's College London
Mike Jay will discuss with Dr Matt Butler the fascinating stories and cast of characters involved in the discovery of laughing gas (nitrous oxide) which is the subject of his latest book Free Radicals...
www.kcl.ac.uk
November 21, 2025 at 12:31 PM
Still a few tickets left for this event with the amazing @mikejay.bsky.social tonight 6-7.30 at @kingsioppn.bsky.social
All welcome as Mike discusses his new book on the discovery of N2O & the birth of psychedelic science👌👌
All welcome as Mike discusses his new book on the discovery of N2O & the birth of psychedelic science👌👌
Reposted by Tim Nicholson
There is still time to get your ticket for Mike Jay's talk tonight 👇
Do you know the history behind the discovery of laughing gas?
Join @mikejay.bsky.social, historian of science and medicine as he discusses his latest book, Free Radicals.
21/11, 6pm Wolfson Lecture Theatre, SE5 8AB
Tickets: www.kcl.ac.uk/events/free-...
Join @mikejay.bsky.social, historian of science and medicine as he discusses his latest book, Free Radicals.
21/11, 6pm Wolfson Lecture Theatre, SE5 8AB
Tickets: www.kcl.ac.uk/events/free-...
Free Radicals - In conversation with Mike Jay | King's College London
Mike Jay will discuss with Dr Matt Butler the fascinating stories and cast of characters involved in the discovery of laughing gas (nitrous oxide) which is the subject of his latest book Free Radicals...
www.kcl.ac.uk
November 21, 2025 at 10:03 AM
There is still time to get your ticket for Mike Jay's talk tonight 👇
Reposted by Tim Nicholson
📣All welcome to special @kingsioppn.bsky.social event
Fri 21st 18:00-19:30
IoPPN, Denmark Hill
The ever brilliant @mikejay.bsky.social will be discussing his latest book Free Radicals on the discovery of nitrous oxide & the birth of psychedelic science
Tickets £5 - free for KCL staff & students👇
Fri 21st 18:00-19:30
IoPPN, Denmark Hill
The ever brilliant @mikejay.bsky.social will be discussing his latest book Free Radicals on the discovery of nitrous oxide & the birth of psychedelic science
Tickets £5 - free for KCL staff & students👇
November 6, 2025 at 7:04 PM
📣All welcome to special @kingsioppn.bsky.social event
Fri 21st 18:00-19:30
IoPPN, Denmark Hill
The ever brilliant @mikejay.bsky.social will be discussing his latest book Free Radicals on the discovery of nitrous oxide & the birth of psychedelic science
Tickets £5 - free for KCL staff & students👇
Fri 21st 18:00-19:30
IoPPN, Denmark Hill
The ever brilliant @mikejay.bsky.social will be discussing his latest book Free Radicals on the discovery of nitrous oxide & the birth of psychedelic science
Tickets £5 - free for KCL staff & students👇
Reposted by Tim Nicholson
I'm heartbroken to learn of the passing of Dr. Mark Hallett.
A few thoughts in remembrance…
A few thoughts in remembrance…
November 4, 2025 at 4:44 PM
I'm heartbroken to learn of the passing of Dr. Mark Hallett.
A few thoughts in remembrance…
A few thoughts in remembrance…
Reposted by Tim Nicholson
For decades, we have tried to suppress γ-secretase, lower Aβ42 levels, or remove amyloid from the brain. We show that PSEN1 mutations already reduce γ-secretase activity and lower Aβ42. Why restoring Aβ42 is the way forward for #Alzheimers, via @Brain1878
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease
Espay et al. challenge the view that Alzheimer’s disease is caused by increased gamma-secretase activity and overproduction of Aβ42. Instead, they suggest
academic.oup.com
November 6, 2025 at 7:15 PM
For decades, we have tried to suppress γ-secretase, lower Aβ42 levels, or remove amyloid from the brain. We show that PSEN1 mutations already reduce γ-secretase activity and lower Aβ42. Why restoring Aβ42 is the way forward for #Alzheimers, via @Brain1878
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Reposted by Tim Nicholson
#OnThisDay in 1977 the artist William Kurelek died. His 1953 autobiographical painting, The Maze, painted during his time as a patient at the Maudsley Hospital, continues to captivate visitors to Bethlem Museum of the Mind. Discover this intriguing artwork here: bit.ly/MOTMMaze
November 2, 2025 at 5:13 PM
#OnThisDay in 1977 the artist William Kurelek died. His 1953 autobiographical painting, The Maze, painted during his time as a patient at the Maudsley Hospital, continues to captivate visitors to Bethlem Museum of the Mind. Discover this intriguing artwork here: bit.ly/MOTMMaze