Tyler Ryan Sizemore
@tsizzle2.bsky.social
Post-doc in @CarlsonLab_Yale. Insectophile. Sensory Neurobiology. Social Media Coordinator for @CSHLflycourse. #FirstGen. He/Him. Opinions are my own. tylersizemore.com
Reposted by Tyler Ryan Sizemore
Happy to share our Current Opinion on the 'Neural basis of sexually dimorphic decision-making', written with Megan Day.
Many thanks to @jefferis.bsky.social for the invite to be part of this special issue on Sexual Dimorphism in the Brain.
www.sciencedirect.com/science/arti...
Many thanks to @jefferis.bsky.social for the invite to be part of this special issue on Sexual Dimorphism in the Brain.
www.sciencedirect.com/science/arti...
Neural basis of sexually dimorphic decision-making
Animals continually arbitrate between incompatible behaviors: whether to feed or flee, mate or fight, sleep or explore. The brain must select, suppres…
www.sciencedirect.com
December 18, 2025 at 12:04 PM
Happy to share our Current Opinion on the 'Neural basis of sexually dimorphic decision-making', written with Megan Day.
Many thanks to @jefferis.bsky.social for the invite to be part of this special issue on Sexual Dimorphism in the Brain.
www.sciencedirect.com/science/arti...
Many thanks to @jefferis.bsky.social for the invite to be part of this special issue on Sexual Dimorphism in the Brain.
www.sciencedirect.com/science/arti...
Reposted by Tyler Ryan Sizemore
This really is, as Sara says, INSANE memory-holing: Minutes after FCC Chairman Carr told Congress that the FCC "is not" an independent agency (see video below via @atrupar.com), the FCC website started getting scrubbed to remove that description.
December 17, 2025 at 6:53 PM
This really is, as Sara says, INSANE memory-holing: Minutes after FCC Chairman Carr told Congress that the FCC "is not" an independent agency (see video below via @atrupar.com), the FCC website started getting scrubbed to remove that description.
Reposted by Tyler Ryan Sizemore
This is an important moment, and we need to explain to the public why it's important.
An agency with the power to decide who gets to broadcast is supposed to be independent from the president so it won't abuse that power. If it's not, then we are letting the president seize the power to censor.
An agency with the power to decide who gets to broadcast is supposed to be independent from the president so it won't abuse that power. If it's not, then we are letting the president seize the power to censor.
LUHAN: Is the FCC an independent agency?
CARR: I think th---
L: Yes or no
C: There's a test for this in the la---
L: It's yes or no, Brendan! On your website, it simply says, man, 'the FCC is independent.' This isn't a trick question
C: The FCC is not
L: So is your website lying?
C: Possibly
CARR: I think th---
L: Yes or no
C: There's a test for this in the la---
L: It's yes or no, Brendan! On your website, it simply says, man, 'the FCC is independent.' This isn't a trick question
C: The FCC is not
L: So is your website lying?
C: Possibly
December 17, 2025 at 5:48 PM
This is an important moment, and we need to explain to the public why it's important.
An agency with the power to decide who gets to broadcast is supposed to be independent from the president so it won't abuse that power. If it's not, then we are letting the president seize the power to censor.
An agency with the power to decide who gets to broadcast is supposed to be independent from the president so it won't abuse that power. If it's not, then we are letting the president seize the power to censor.
Reposted by Tyler Ryan Sizemore
Truly insane that the networks took this speech live after refusing to do the same for Biden in 2022
In a nationwide address that major US TV networks are carrying live, President Trump announces 1,450,000 military members will receive a "warrior dividend" of $1776 before Christmas.
December 18, 2025 at 2:17 AM
Truly insane that the networks took this speech live after refusing to do the same for Biden in 2022
Reposted by Tyler Ryan Sizemore
I'm told that HHS has just terminated all funding agreements with the American Academy of Pediatrics.
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
December 17, 2025 at 6:00 PM
I'm told that HHS has just terminated all funding agreements with the American Academy of Pediatrics.
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Reposted by Tyler Ryan Sizemore
We can't work with foreign collaborators, but they can send money to a foreign PI to conduct an ethically questionable study in a vulnerable population in another foreign country?
This is what corruption looks like.
This is what corruption looks like.
December 17, 2025 at 5:34 PM
We can't work with foreign collaborators, but they can send money to a foreign PI to conduct an ethically questionable study in a vulnerable population in another foreign country?
This is what corruption looks like.
This is what corruption looks like.
Reposted by Tyler Ryan Sizemore
The National Science Board, which oversees NSF, has published recommendations to update the foundation's merit review (which was just updated).
Below are the main points. www.nsf.gov/nsb/updates/...
Below are the main points. www.nsf.gov/nsb/updates/...
December 17, 2025 at 8:07 PM
The National Science Board, which oversees NSF, has published recommendations to update the foundation's merit review (which was just updated).
Below are the main points. www.nsf.gov/nsb/updates/...
Below are the main points. www.nsf.gov/nsb/updates/...
Reposted by Tyler Ryan Sizemore
Excited to announce the final version of the Mosquito Cell Atlas is out now in @cellpress.bsky.social!! 🦟🩸
There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields!
www.cell.com/cell/fulltex...
There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields!
www.cell.com/cell/fulltex...
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
A comprehensive single-nucleus RNA-seq atlas of >367,000 nuclei from male and female
Aedes aegypti mosquitoes reveals sexual dimorphism in sensory systems and brain cell
types and widespread co-expres...
www.cell.com
October 30, 2025 at 4:05 PM
Excited to announce the final version of the Mosquito Cell Atlas is out now in @cellpress.bsky.social!! 🦟🩸
There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields!
www.cell.com/cell/fulltex...
There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields!
www.cell.com/cell/fulltex...
Reposted by Tyler Ryan Sizemore
Our preprint is out! www.biorxiv.org/content/10.1...
Peter Skovorodnikov and I are excited to present FERAL: a new video-understanding toolkit that maps raw video directly to behavior, no pose estimation required.
It works across species, from lab to field, and even in collective systems. (🧵1/n)
Peter Skovorodnikov and I are excited to present FERAL: a new video-understanding toolkit that maps raw video directly to behavior, no pose estimation required.
It works across species, from lab to field, and even in collective systems. (🧵1/n)
FERAL: A Video-Understanding System for Direct Video-to-Behavior Mapping
Animal behavior unfolds continuously in time, yet quantitative analyses often require segmenting it into discrete, interpretable states. Although manual annotation can achieve this, it remains slow, s...
www.biorxiv.org
November 19, 2025 at 6:30 PM
Our preprint is out! www.biorxiv.org/content/10.1...
Peter Skovorodnikov and I are excited to present FERAL: a new video-understanding toolkit that maps raw video directly to behavior, no pose estimation required.
It works across species, from lab to field, and even in collective systems. (🧵1/n)
Peter Skovorodnikov and I are excited to present FERAL: a new video-understanding toolkit that maps raw video directly to behavior, no pose estimation required.
It works across species, from lab to field, and even in collective systems. (🧵1/n)
Reposted by Tyler Ryan Sizemore
🎉 Thrilled to see our #MosquitoCellAtlas featured on the cover of @cp-cell.bsky.social ! This mosaic represents 367K cells across 19 tissues, unveiling the complex biology that makes mosquitoes the world's deadliest animals. Beautiful art by @somedonkey.bsky.social meets the #Vosshalllab science! 🦟🎨
New issue alert! 👉 cell.com/cell/current
On the cover: The mosquito mosaic represents the tissues of the atlas presented by Goldman et al. The atlas reveals the complex diversity underlying the mosquito’s remarkable ability to locate human hosts and transmit deadly pathogens
On the cover: The mosquito mosaic represents the tissues of the atlas presented by Goldman et al. The atlas reveals the complex diversity underlying the mosquito’s remarkable ability to locate human hosts and transmit deadly pathogens
December 11, 2025 at 4:28 PM
🎉 Thrilled to see our #MosquitoCellAtlas featured on the cover of @cp-cell.bsky.social ! This mosaic represents 367K cells across 19 tissues, unveiling the complex biology that makes mosquitoes the world's deadliest animals. Beautiful art by @somedonkey.bsky.social meets the #Vosshalllab science! 🦟🎨
Reposted by Tyler Ryan Sizemore
🧵 NSF is reducing external review requirements and eliminating routine expert panels, citing staff shortages that this administration implemented. This change expands program officer authority. But the solution to flawed accountability isn't less public accountability.
NSF plans to streamline merit review to heal self-inflicted staffing wound www.science.org/content/arti...
NSF pares down grant-review process, reducing influence of outside scientists
Memo cites overburdened staff, but some say move also aims to elevate White House priorities
www.science.org
December 16, 2025 at 12:33 AM
🧵 NSF is reducing external review requirements and eliminating routine expert panels, citing staff shortages that this administration implemented. This change expands program officer authority. But the solution to flawed accountability isn't less public accountability.
Reposted by Tyler Ryan Sizemore
New stories out about Official NIH Policy about "remediating" NIH applications so that they can be considered for funding.
First, a story in STAT...
www.statnews.com/2025/12/15/n...
1/9
First, a story in STAT...
www.statnews.com/2025/12/15/n...
1/9
NIH specifies how grant reviewers should ensure alignment with Trump priorities
In a memo obtained by STAT, the NIH gives specific steps on how grant reviewers can check for alignment with administration priorities.
www.statnews.com
December 16, 2025 at 1:16 AM
New stories out about Official NIH Policy about "remediating" NIH applications so that they can be considered for funding.
First, a story in STAT...
www.statnews.com/2025/12/15/n...
1/9
First, a story in STAT...
www.statnews.com/2025/12/15/n...
1/9
Reposted by Tyler Ryan Sizemore
Strikingly different neurotransmitter release strategies in dopaminergic subclasses.
buff.ly/Jr3RdzA
buff.ly/Jr3RdzA
December 14, 2025 at 11:28 PM
Strikingly different neurotransmitter release strategies in dopaminergic subclasses.
buff.ly/Jr3RdzA
buff.ly/Jr3RdzA
Reposted by Tyler Ryan Sizemore
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
December 15, 2025 at 6:26 PM
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
Reposted by Tyler Ryan Sizemore
very excited to share some of the final bits of work from my PhD! 🎉 we find that phasic DA in the accumbens simultaneously tracks persistent motivation towards reward cues in addition to new learning (but maybe not RPE?!) in sign-tracking rats. check out the preprint below!
Phasic dopamine encodes persistent attraction to reward cues https://www.biorxiv.org/content/10.64898/2025.12.09.693300v1
December 12, 2025 at 6:29 PM
very excited to share some of the final bits of work from my PhD! 🎉 we find that phasic DA in the accumbens simultaneously tracks persistent motivation towards reward cues in addition to new learning (but maybe not RPE?!) in sign-tracking rats. check out the preprint below!
Reposted by Tyler Ryan Sizemore
Release FB2025_05 of FlyBase.org is live!
'New this release' information is here flybase.org/static/new-t...
'New this release' information is here flybase.org/static/new-t...
FlyBase: New In This Release
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
December 12, 2025 at 7:18 PM
Release FB2025_05 of FlyBase.org is live!
'New this release' information is here flybase.org/static/new-t...
'New this release' information is here flybase.org/static/new-t...
Reposted by Tyler Ryan Sizemore
Made a site comparing the sizes of living things :)
The great Julius Csotonyi spent 5 months painting over 60 illustrations for the site, no ai used
> neal.fun/size-of-life/
The great Julius Csotonyi spent 5 months painting over 60 illustrations for the site, no ai used
> neal.fun/size-of-life/
December 10, 2025 at 4:03 PM
Made a site comparing the sizes of living things :)
The great Julius Csotonyi spent 5 months painting over 60 illustrations for the site, no ai used
> neal.fun/size-of-life/
The great Julius Csotonyi spent 5 months painting over 60 illustrations for the site, no ai used
> neal.fun/size-of-life/
Reposted by Tyler Ryan Sizemore
New paper covering what we think is a pretty nice and comprehensive overview over tools suitable for neuroethology in butterflies and moths.
Also, check out the whole special issue if you're an insect neuroethologist.
@neuroethology.org @dzg-neurobiology.bsky.social
doi.org/10.1007/s003...
Also, check out the whole special issue if you're an insect neuroethologist.
@neuroethology.org @dzg-neurobiology.bsky.social
doi.org/10.1007/s003...
Emerging tools to advance neuroethology in butterflies and moths - Journal of Comparative Physiology A
Journal of Comparative Physiology A - Butterflies and moths have played historically important roles in developing our understanding of both ecology and evolutionary biology, and neuroethology. In...
doi.org
December 12, 2025 at 10:04 AM
New paper covering what we think is a pretty nice and comprehensive overview over tools suitable for neuroethology in butterflies and moths.
Also, check out the whole special issue if you're an insect neuroethologist.
@neuroethology.org @dzg-neurobiology.bsky.social
doi.org/10.1007/s003...
Also, check out the whole special issue if you're an insect neuroethologist.
@neuroethology.org @dzg-neurobiology.bsky.social
doi.org/10.1007/s003...
Reposted by Tyler Ryan Sizemore
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Tyler Ryan Sizemore
its millipede time
December 12, 2025 at 3:49 AM
its millipede time
Reposted by Tyler Ryan Sizemore
Wendy Valencia-Montoya and team uncover thermal infrared as one of the most ancient pollination signals uniting plants and animals. From the field to single proteins.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 11, 2025 at 9:09 PM
Wendy Valencia-Montoya and team uncover thermal infrared as one of the most ancient pollination signals uniting plants and animals. From the field to single proteins.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Tyler Ryan Sizemore
a grad student at another institution emailed me about their interest in my lab. they attached their thesis proposal, which contained several inaccuracies regarding my work. and also a reference that doesn't exist.
December 11, 2025 at 4:25 PM
a grad student at another institution emailed me about their interest in my lab. they attached their thesis proposal, which contained several inaccuracies regarding my work. and also a reference that doesn't exist.
Reposted by Tyler Ryan Sizemore
Ancient Plants Used Infrared Radiation to Attract Their Pollinators #research 🧠 🧪🧬 #AcademicSky #higherEd
www.mcb.harvard.edu/department/n... @nbellono.bsky.social @rachellegaudet.bsky.social @harvardoeb.bsky.social @science.org
www.mcb.harvard.edu/department/n... @nbellono.bsky.social @rachellegaudet.bsky.social @harvardoeb.bsky.social @science.org
Ancient Plants Used Infrared Radiation to Attract Their Pollinators - Harvard University - Department of Molecular & Cellular Biology
Long before flowers painted the planet in brilliant colors, some of Earth’s earliest plants were glowing—not with pigment, but with heat. A new study from the lab of […]
www.mcb.harvard.edu
December 11, 2025 at 7:21 PM
Ancient Plants Used Infrared Radiation to Attract Their Pollinators #research 🧠 🧪🧬 #AcademicSky #higherEd
www.mcb.harvard.edu/department/n... @nbellono.bsky.social @rachellegaudet.bsky.social @harvardoeb.bsky.social @science.org
www.mcb.harvard.edu/department/n... @nbellono.bsky.social @rachellegaudet.bsky.social @harvardoeb.bsky.social @science.org
Reposted by Tyler Ryan Sizemore
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
PAR-26-121: Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
files.simpler.grants.gov
December 11, 2025 at 6:48 PM
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
Reposted by Tyler Ryan Sizemore
We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect.
The full study is now online at Cell. @cp-cell.bsky.social
Paper 👉 www.cell.com/cell/fulltex...
Thread for a synopsis 👉
bsky.app/profile/alex...
The full study is now online at Cell. @cp-cell.bsky.social
Paper 👉 www.cell.com/cell/fulltex...
Thread for a synopsis 👉
bsky.app/profile/alex...
December 5, 2025 at 4:29 PM
We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect.
The full study is now online at Cell. @cp-cell.bsky.social
Paper 👉 www.cell.com/cell/fulltex...
Thread for a synopsis 👉
bsky.app/profile/alex...
The full study is now online at Cell. @cp-cell.bsky.social
Paper 👉 www.cell.com/cell/fulltex...
Thread for a synopsis 👉
bsky.app/profile/alex...