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Yonatan Tzur

Yonatan Tzur

@tzurlab.bsky.social

570 followers 110 following 21 posts

Yonatan Tzur's laboratory at the Genetics dep. of the Hebrew University. focusing on meiosis, germline and genome engineering

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Reposted by Yonatan Tzur

Oded Rechavi @odedrechavi.bsky.social · 20d

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Yonatan Tzur @tzurlab.bsky.social · Sep 25

Thanks also to YIsrael Rappaport who started this project, and Hanna Achache ,who pulled us out of the bog.
Also, a huge shoutout to the editor and staff of
@natcomms.nature.com, who were patient, helpful, and accessible. The most amazing professionals I had the good fortune to work with.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

How do they do it? We are finding out…
This work has been almost completely done by the amazing student Roni Falk. I am sorry to see her leave for a postdoc, but I know it is she could become an independent scientist who will contribute a lot to the field of #Fertility.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

In line with the role of lncRNA in promoting meiosis, their level increases as the cells move towards meiosis, and the number of FBF-2 condensates decreases. Thus, the lncRNAs promote meiosis by binding FBF-2 and deactivating it by promoting its condensation.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

Indeed, in the triple lncRNA mutant, transcripts that are repressed by FBF-2 were over-repressed. At least one of the lncRNAs colocalizes with FBF-2 in peri-nuclear condensates and P granules. Deletion of the lncRNAs reduced FBF-2 condensates, and it stayed in the cytoplasm.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

We deleted the genes encoding these three lncRNAs and identified a severe reduction of proliferating germ cells and progeny. This phenotype is similar to overexpression of FBF-2, suggesting that the lncRNAs repress FBF-2.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

LncRNAs are highly expressed in the gonads, but KO of single genes usually results in no obvious phenotype. 3 lncRNAs bind the protein FBF-2 that tilts the balance of germ cells towards stem cell proliferation, and delays meiosis.

Yonatan Tzur @tzurlab.bsky.social · Sep 25

So excited about our recent 📜in @natcomms.nature.com

In short, we found 3 lncRNAs that ensure oocyte differentiation by condensing FBF-2, a protein that prevents meiosis entry. And yes, a homologous mechanism probably exists in mammals.
#fertility #lncRNA #meiosis
nature.com/articles/s41...

Three lncRNAs promote PUM protein condensation and germline differentiation - Nature Communications

RNA-binding FBF proteins control germline stem cell differentiation. Here, the authors show that three long non-coding RNAs bind, condense, and thus inhibit FBFs to promote the transition of germline stem cells into meiosis.

Yonatan Tzur @tzurlab.bsky.social · Aug 11

One of the best collaborations we ever had.
Brainstorming with ‪@ethanewe.bsky.social‬ whenever a new result came up, was so uplifting and we felt like we boldly go where no one has gone before.
Top tier research institutions: grab him while you can!

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · Aug 11

In summary, we think that low oxygen levels signal reproductive permissive environments and promote germline maintenance. This neurons-to-germline communication may be super important for enabling animals to sense, adapt, and propagate in fluctuating environments. 🔥🍂🍎🪱

Reposted by Yonatan Tzur

Oded Rechavi @odedrechavi.bsky.social · Aug 11

WOoo! Hot pre-print alert! 🔥 Check out our new story - We describe evidence that "neuronal oversight" of germline small RNAs prevents sterility and allows lab-domesticated C. elegans to reproduce when temperatures go up (1/2)
www.biorxiv.org/content/10.1...

Yonatan Tzur @tzurlab.bsky.social · Aug 11

‪So proud we could take part in this amazing project!
Germline/meiosis crowd, you must check this out. A whole new dimension of non-cell autonomous control on gametogenesis.
Also, triple shoutout for @ethanewe.bsky.social . A great PI on the way
#meiosis #germline #ncRNA

Oded Rechavi @odedrechavi.bsky.social · Aug 11

WOoo! Hot pre-print alert! 🔥 Check out our new story - We describe evidence that "neuronal oversight" of germline small RNAs prevents sterility and allows lab-domesticated C. elegans to reproduce when temperatures go up (1/2)
www.biorxiv.org/content/10.1...

Reposted by Yonatan Tzur

Erich M. Schwarz @erichmschwarz.bsky.social · Aug 1

After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...

Yonatan Tzur @tzurlab.bsky.social · Aug 1

We go to so many meetings and conferences that most just blend into our memory.
But rare ones stand out and truly change the way we think and do science.
👇This was one of those that will stay a part of me.

Oded Rechavi @odedrechavi.bsky.social · Jul 31

🥂This was the highlight of my year. The "instigators", led by local master of the ceremony @svobodalab.bsky.social will never forget the privilege of organizing it and i think every participant will treasure the experience forever ❤️ @nature.com @josiegz.bsky.social www.nature.com/articles/d41...

Scientific bedlam at the world’s weirdest and wildest research conference

Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.

Yonatan Tzur @tzurlab.bsky.social · Jun 19

A kind invitation by the Cell Biology Department of @charlesuni.cuni.cz brought Israeli scientist stranded in Prague after the #TCTeAC to do what we love best - participate in exciting scientific discussions!

Yonatan Tzur @tzurlab.bsky.social · Jun 11

@barakrotblat.bsky.social : "close you eyes and think about being alive". Me: "is it worth living in glucose starvation?" #TCTeAC

Reposted by Yonatan Tzur

Itai Yanai @itaiyanai.bsky.social · Jun 11

@tzurlab.bsky.social Yonathan Tzur at Woodstock Night Science conference #TCTEAC

Reposted by Yonatan Tzur

petrahyrossova.bsky.social @petrahyrossova.bsky.social · Jun 11

Reposted by Yonatan Tzur

Natanella Illouz-Eliaz @natanellae.bsky.social · Jun 11

Balance as a key in life and our biological question. Yonatan Tzur #TCTeAC

Reposted by Yonatan Tzur

Oded Rechavi @odedrechavi.bsky.social · Jun 10

And now Ahmed Elewa with a beautiful development biology talk

Yonatan Tzur @tzurlab.bsky.social · Jun 10

And here it starts:

@woodstocknightsci.bsky.social

#TCTeAC
#theconferencetoendallconferences

Yonatan Tzur @tzurlab.bsky.social · Jun 10

Another great example of the pivotal role of MAPK in reproduction

Soni Lacefield @lacefieldlab.bsky.social · Jun 9

Super excited to post our new publication on the role of MOS/MAPK signaling in maintaining the egg transcriptome. Great collaboration with Britt Goods lab! rep.bioscientifica.com/view/journal...

rep.bioscientifica.com

Yonatan Tzur @tzurlab.bsky.social · Jun 9

With @gazitroi.bsky.social on our way to
#theconferencetoendallconferences

Reposted by Yonatan Tzur

Oded Rechavi @odedrechavi.bsky.social · May 17

In this conference we couldn't care less where you published your story because 1. we only care if it's interesting and good and 2. participants will discuss unpublished work

Oded Rechavi @odedrechavi.bsky.social · Apr 1

Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz

Yonatan Tzur @tzurlab.bsky.social · Dec 22

With more research in this direction the former may not be so certain!

Björn Schumacher @bjornschumacher.bsky.social · Dec 22

"Nothing in life is certain except death, taxes and the second law of thermodynamics", the latter causing the first through aging (doi.org/10.1038/s435...) and taxes should better be devoted to find out what we can do about it.

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

Yonatan Tzur @tzurlab.bsky.social · Dec 2

GIF where you're from