Ethan (Chee Kiang) Ewe
@ethanewe.bsky.social
Postdoc, firstgen, scientist, worm breeder, cats dad 🏳️🌈
Pinned
🔥my latest paper from @odedrechavi.bsky.social lab🔥
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
So many new tools for gene tagging these days! I’m a happy boy! :)
TAG-IN, a swappable strategy for endogenous gene tagging in Caenorhabditis elegans using cassette exchange https://www.biorxiv.org/content/10.64898/2026.01.16.700006v1
January 20, 2026 at 8:42 AM
So many new tools for gene tagging these days! I’m a happy boy! :)
Reposted by Ethan (Chee Kiang) Ewe
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
January 15, 2026 at 7:48 AM
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
“The proliferation of AI tools in science risks introducing a phase of scientific enquiry in which we produce more but understand less.”
Artificial intelligence and illusions of understanding in scientific research | Nature www.nature.com/articles/s41...
Artificial intelligence and illusions of understanding in scientific research - Nature
The proliferation of artificial intelligence tools in scientific research risks creating illusions of understanding, where scientists believe they understand more about the world than they actual...
www.nature.com
January 16, 2026 at 11:09 AM
“The proliferation of AI tools in science risks introducing a phase of scientific enquiry in which we produce more but understand less.”
Reposted by Ethan (Chee Kiang) Ewe
FLInt 2.0: Robust and customizable single shot integration in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.12.699147v1
January 14, 2026 at 4:33 AM
FLInt 2.0: Robust and customizable single shot integration in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.12.699147v1
Reposted by Ethan (Chee Kiang) Ewe
Modular gene tagging in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.15.699741v1
January 16, 2026 at 3:32 AM
Modular gene tagging in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.15.699741v1
Reposted by Ethan (Chee Kiang) Ewe
Improved Dye-Filling Protocol for Multiple Nematode Species #micropublication #biology #data #caltechlibrary #Celegans #Pristionchuspacificus #Methods #Methodology https://micropublication.org/journals/biology/micropub-biology-001963
January 14, 2026 at 8:05 PM
Improved Dye-Filling Protocol for Multiple Nematode Species #micropublication #biology #data #caltechlibrary #Celegans #Pristionchuspacificus #Methods #Methodology https://micropublication.org/journals/biology/micropub-biology-001963
Reposted by Ethan (Chee Kiang) Ewe
A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers.
buff.ly/K7CGFLV
buff.ly/K7CGFLV
January 14, 2026 at 11:02 AM
A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers.
buff.ly/K7CGFLV
buff.ly/K7CGFLV
Highly recommended!
There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
Pathway to Independence programme | Development | The Company of Biologists
Pathway to Independence programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Launched in 2022, Development’s Pathway Independence programm...
journals.biologists.com
January 13, 2026 at 8:40 PM
Highly recommended!
@maxfarnworth.bsky.social is amazing-ier! 😆
January 13, 2026 at 7:41 PM
@maxfarnworth.bsky.social is amazing-ier! 😆
Reposted by Ethan (Chee Kiang) Ewe
Environment & evolution take centre stage at January’s #DevPres
📅 14 January 15:00 GMT/UTC
Three talks, three unique stories. Told by @ethanewe.bsky.social @maxfarnworth.bsky.social @sonyawiden.bsky.social
Chair: @pritiagarwal.bsky.social
🔗Learn more & register: us02web.zoom.us/webinar/regi...
📅 14 January 15:00 GMT/UTC
Three talks, three unique stories. Told by @ethanewe.bsky.social @maxfarnworth.bsky.social @sonyawiden.bsky.social
Chair: @pritiagarwal.bsky.social
🔗Learn more & register: us02web.zoom.us/webinar/regi...
January 12, 2026 at 3:54 PM
Environment & evolution take centre stage at January’s #DevPres
📅 14 January 15:00 GMT/UTC
Three talks, three unique stories. Told by @ethanewe.bsky.social @maxfarnworth.bsky.social @sonyawiden.bsky.social
Chair: @pritiagarwal.bsky.social
🔗Learn more & register: us02web.zoom.us/webinar/regi...
📅 14 January 15:00 GMT/UTC
Three talks, three unique stories. Told by @ethanewe.bsky.social @maxfarnworth.bsky.social @sonyawiden.bsky.social
Chair: @pritiagarwal.bsky.social
🔗Learn more & register: us02web.zoom.us/webinar/regi...
Reposted by Ethan (Chee Kiang) Ewe
Paired with the show, Bob Goldstein created the world's longest microtubule, ascending the Genome Science Building's spiral stairs, to honor Emeritus Professor Ted Salmon
January 11, 2026 at 11:17 PM
Paired with the show, Bob Goldstein created the world's longest microtubule, ascending the Genome Science Building's spiral stairs, to honor Emeritus Professor Ted Salmon
I’ve been so lucky to be part of the PI Programme by @biologists.bsky.social this past year and met so many incredible people! Come hear us talk about what keeps us up at night this Wednesday!
Join us next week for #DevPres to hear 3 of our PI fellows talk about the environment & evolution
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
January 11, 2026 at 7:48 AM
I’ve been so lucky to be part of the PI Programme by @biologists.bsky.social this past year and met so many incredible people! Come hear us talk about what keeps us up at night this Wednesday!
Reposted by Ethan (Chee Kiang) Ewe
A non-canonical role for UPRER during heat stress in C. elegans. https://www.biorxiv.org/content/10.64898/2026.01.08.698479v1
January 10, 2026 at 1:32 AM
A non-canonical role for UPRER during heat stress in C. elegans. https://www.biorxiv.org/content/10.64898/2026.01.08.698479v1
🤯🤯🤯
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 9, 2026 at 4:20 PM
🤯🤯🤯
Reposted by Ethan (Chee Kiang) Ewe
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 8, 2026 at 8:51 AM
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
Reposted by Ethan (Chee Kiang) Ewe
An important study that demonstrates what we should already know: we must be very cautious about inferring the phenotypic consequences of single gene variants to human evolution.
While stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪
Explainer🧵👇1/n
Explainer🧵👇1/n
Evaluating the effects of archaic protein-altering variants in living human adults
Promise and pitfalls of using large biobanks to study impacts of archaic protein-coding variants in living humans.
www.science.org
December 19, 2025 at 1:30 PM
An important study that demonstrates what we should already know: we must be very cautious about inferring the phenotypic consequences of single gene variants to human evolution.
Reposted by Ethan (Chee Kiang) Ewe
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 5, 2026 at 12:51 PM
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
Reposted by Ethan (Chee Kiang) Ewe
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 6, 2026 at 6:33 PM
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Reposted by Ethan (Chee Kiang) Ewe
If you made a Venn diagram of every weird person I knew in Silicon Valley during the first dot-com boom, centrifuged it, extracted the pellet, and re-suspended it in high-proof eugenics with a splash of AI, you'd end up with something like this.
It'll take a strong stomach to read this "gift" link.
It'll take a strong stomach to read this "gift" link.
Can You Optimize Love?
www.nytimes.com
January 6, 2026 at 11:53 PM
If you made a Venn diagram of every weird person I knew in Silicon Valley during the first dot-com boom, centrifuged it, extracted the pellet, and re-suspended it in high-proof eugenics with a splash of AI, you'd end up with something like this.
It'll take a strong stomach to read this "gift" link.
It'll take a strong stomach to read this "gift" link.
Reposted by Ethan (Chee Kiang) Ewe
Here's the first whole brain-wide expression and functional analysis of all members of the C. elegans DMRT family, a group of transcription factors that are consistently deployed to control sex-specific differentiation programs across the animal kingdom.
A panoramic view of the expression and function of the Doublesex/DMRT gene family in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.01.697290v1
January 5, 2026 at 8:49 PM
Here's the first whole brain-wide expression and functional analysis of all members of the C. elegans DMRT family, a group of transcription factors that are consistently deployed to control sex-specific differentiation programs across the animal kingdom.
Reposted by Ethan (Chee Kiang) Ewe
You can learn more about our PI programme here: journals.biologists.com/dev/pages/pi....
We are currently accepting new applications for PI fellows until 2 February 2026.
We are currently accepting new applications for PI fellows until 2 February 2026.
January 5, 2026 at 12:38 PM
You can learn more about our PI programme here: journals.biologists.com/dev/pages/pi....
We are currently accepting new applications for PI fellows until 2 February 2026.
We are currently accepting new applications for PI fellows until 2 February 2026.
Reposted by Ethan (Chee Kiang) Ewe
Join us next week for #DevPres to hear 3 of our PI fellows talk about the environment & evolution
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
January 5, 2026 at 12:38 PM
Join us next week for #DevPres to hear 3 of our PI fellows talk about the environment & evolution
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
14 January 15:00 GMT/UTC
With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.
us02web.zoom.us/webinar/regi...
#DevPres
Reposted by Ethan (Chee Kiang) Ewe
Another YouTube Tutorial – This one on Proximity Labeling and connected to our recent EMBO J. paper (PMID: 41381733). This is a recording of a talk at the IDeA National Resource for Quantitative Proteomics in Little Rock AR. One of the top facilities in the country!
www.youtube.com/watch?v=0T9P...
www.youtube.com/watch?v=0T9P...
Core Directors' Symposium - 2025 - David Fay
YouTube video by IDeA National Resource for Quantitative Proteomics
www.youtube.com
January 4, 2026 at 3:40 PM
Another YouTube Tutorial – This one on Proximity Labeling and connected to our recent EMBO J. paper (PMID: 41381733). This is a recording of a talk at the IDeA National Resource for Quantitative Proteomics in Little Rock AR. One of the top facilities in the country!
www.youtube.com/watch?v=0T9P...
www.youtube.com/watch?v=0T9P...
Reposted by Ethan (Chee Kiang) Ewe
Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
What a way to start the new year with one more submission to BioRxiv. This one is on how GTSF-1 enable RdRP activity in nematodes (for Piwi aficionados: correct, it does not affect Piwi😊)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes
GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but associates with the RNA-dependent RNA pol...
www.biorxiv.org
January 4, 2026 at 3:13 PM
Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
Reposted by Ethan (Chee Kiang) Ewe
A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.01.03.697488v1
January 4, 2026 at 1:00 AM
A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.01.03.697488v1