📣Excited to announce a new pre-print from the lab 📣
Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org
We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs
#TEsky #RNAsky #ALS
doi.org/10.64898/2026.01.09.698641
Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org
We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs
#TEsky #RNAsky #ALS
doi.org/10.64898/2026.01.09.698641
TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues
TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from im...
doi.org
January 10, 2026 at 5:52 PM
📣Excited to announce a new pre-print from the lab 📣
Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org
We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs
#TEsky #RNAsky #ALS
doi.org/10.64898/2026.01.09.698641
Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org
We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs
#TEsky #RNAsky #ALS
doi.org/10.64898/2026.01.09.698641
#TEsky still have to read the paper but sounds very interesting.
Now online in Cancer Discovery @aacrjournals.bsky.social: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by Michael Lee, Yuannyu Zhang, Jian Xu, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social
January 7, 2026 at 10:55 AM
#TEsky still have to read the paper but sounds very interesting.
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
New Year, New Paper!🎊
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
www.biorxiv.org
January 7, 2026 at 8:01 PM
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
#TEsky A Pan-TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions doi.org/10.1002/advs...
doi.org
December 29, 2025 at 4:08 PM
#TEsky A Pan-TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions doi.org/10.1002/advs...
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
December 22, 2025 at 12:32 PM
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
🐻❄️❄️ New paper alert! From me Ben & @immler.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1...
A thread 🧵.
#climate #transposons #TESky #polarbear #ursus
@biouea.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1...
A thread 🧵.
#climate #transposons #TESky #polarbear #ursus
@biouea.bsky.social
Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
link.springer.com
December 13, 2025 at 1:43 PM
🐻❄️❄️ New paper alert! From me Ben & @immler.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1...
A thread 🧵.
#climate #transposons #TESky #polarbear #ursus
@biouea.bsky.social
“Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1...
A thread 🧵.
#climate #transposons #TESky #polarbear #ursus
@biouea.bsky.social
The IMPRS-BAC is an outstanding PhD program in Europe. And the endogenous retroviruses in development... what can I say? So much exciting biology to uncover! 🦠🧬#TEsky #StemCells
Read the instructions and apply! ⬇️⬇️⬇️
Read the instructions and apply! ⬇️⬇️⬇️
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
November 28, 2025 at 10:00 AM
The IMPRS-BAC is an outstanding PhD program in Europe. And the endogenous retroviruses in development... what can I say? So much exciting biology to uncover! 🦠🧬#TEsky #StemCells
Read the instructions and apply! ⬇️⬇️⬇️
Read the instructions and apply! ⬇️⬇️⬇️
Molecular effects of transposable element sequences in mammalian cells #TESky
(Wen, MC.C., Welch, J.D. Genome Biol 26, 403 (2025)).
Interesting review of new-found functions of TEs in mammalian genomes, especially over the last three years.
doi.org/10.1186/s130... #TEWorldwide
(Wen, MC.C., Welch, J.D. Genome Biol 26, 403 (2025)).
Interesting review of new-found functions of TEs in mammalian genomes, especially over the last three years.
doi.org/10.1186/s130... #TEWorldwide
Molecular effects of transposable element sequences in mammalian cells - Genome Biology
Transposable elements (TEs) are often epigenetically repressed in eukaryotic cells, but still affect the molecular state of the cell in certain contexts. A flurry of recent studies have elucidated new...
doi.org
November 28, 2025 at 8:05 AM
Molecular effects of transposable element sequences in mammalian cells #TESky
(Wen, MC.C., Welch, J.D. Genome Biol 26, 403 (2025)).
Interesting review of new-found functions of TEs in mammalian genomes, especially over the last three years.
doi.org/10.1186/s130... #TEWorldwide
(Wen, MC.C., Welch, J.D. Genome Biol 26, 403 (2025)).
Interesting review of new-found functions of TEs in mammalian genomes, especially over the last three years.
doi.org/10.1186/s130... #TEWorldwide
#TEsky TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution doi.org/10.1093/nar/...
TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution
Abstract. Transposable elements (TEs) are repetitive DNA sequences typically silenced in normal tissues. Their dysregulation in cancer can significantly im
doi.org
November 27, 2025 at 1:45 PM
#TEsky TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution doi.org/10.1093/nar/...
#TEsky Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa doi.org/10.1093/g3jo...
Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa.
Abstract. Ribosomal DNA (rDNA) occurs as tandem arrays of a repeat unit containing the genes encoding 18S, 5.8S and 28S rRNA separated by spacers. These rR
doi.org
November 24, 2025 at 2:38 PM
#TEsky Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa doi.org/10.1093/g3jo...
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
Environmental fluctuations influence heritable phenotypes through complex molecular mechanisms. In zebrafish (Danio rerio), the interplay between temperature variation, transposable element (TE) activ...
www.biorxiv.org
November 16, 2025 at 10:18 AM
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
November 15, 2025 at 5:23 PM
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
Very happy to share our new paper that just came out: “Chromosomal inversions mediated by tandem insertions of transposable elements”
#TEsky #Transposons
www.biorxiv.org/content/10.1...
#TEsky #Transposons
www.biorxiv.org/content/10.1...
Chromosomal inversions mediated by tandem insertions of transposable elements
Chromosomal inversions play a crucial role in evolution by influencing phenotypes through the linkage of co-adapted alleles. While inversions have been found across a large number of taxa, mapping and...
www.biorxiv.org
January 14, 2025 at 8:23 PM
Very happy to share our new paper that just came out: “Chromosomal inversions mediated by tandem insertions of transposable elements”
#TEsky #Transposons
www.biorxiv.org/content/10.1...
#TEsky #Transposons
www.biorxiv.org/content/10.1...
De La Soul
Tesky Brothers
Thee Oh Sees
Bob Marley
Middle Brother
Khruangbin
dZihan and Kamien
John Prine
Madeleine Peyroux
Tesky Brothers
Thee Oh Sees
Bob Marley
Middle Brother
Khruangbin
dZihan and Kamien
John Prine
Madeleine Peyroux
December 28, 2024 at 11:18 AM
De La Soul
Tesky Brothers
Thee Oh Sees
Bob Marley
Middle Brother
Khruangbin
dZihan and Kamien
John Prine
Madeleine Peyroux
Tesky Brothers
Thee Oh Sees
Bob Marley
Middle Brother
Khruangbin
dZihan and Kamien
John Prine
Madeleine Peyroux
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
May 19, 2025 at 2:01 PM
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
Now online! Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation
This study reveals that composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs.
dlvr.it
August 18, 2025 at 11:30 AM
Zhao, Quinteros & Machado describe unusually large and continuous pericentromeric transposable element-rich regions in all chromosomes of the genome of a Neotropical fig wasp,
🔗 doi.org/10.1093/gbe/evaf158
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf158
#genome #evolution #TEsky
Evolutionary Consequences of Unusually Large Pericentric TE-rich Regions in the Genome of a Neotropical Fig Wasp
Abstract. Transposable elements (TEs), despite generally being considered deleterious, represent a substantial portion of most eukaryotic genomes. Specific
doi.org
September 12, 2025 at 3:36 PM
Zhao, Quinteros & Machado describe unusually large and continuous pericentromeric transposable element-rich regions in all chromosomes of the genome of a Neotropical fig wasp,
🔗 doi.org/10.1093/gbe/evaf158
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf158
#genome #evolution #TEsky
New preprint from the lab led by former masters student AJ Roussel in collaboration with Alexander Suh and @fjruizruano.bsky.social. We found a ~4-fold accumulation of a Neptune #transposon in asexually reproducing "F1" fish hybrids. An unexpected and fascinating finding! #TEsky
Accumulation of a biparentally-inherited Neptune transposable element in natural Killifish hybrids (Fundulus diaphanus X F. heteroclitus)
Transposable elements (TEs) are abundant selfish genetic elements that can mobilize in their host genome, causing DNA damage, mutations and chromosome rearrangements. TE silencing is thus critical, an...
www.biorxiv.org
May 28, 2025 at 11:09 AM
New preprint from the lab led by former masters student AJ Roussel in collaboration with Alexander Suh and @fjruizruano.bsky.social. We found a ~4-fold accumulation of a Neptune #transposon in asexually reproducing "F1" fish hybrids. An unexpected and fascinating finding! #TEsky
Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥
Thrilled to share our new work now published with Kathy Collins, @nogaleslab.bsky.social @berkeleymcb.bsky.social where we investigate this with #cryoEM & biochemistry in 🧪 and cells! #RNAsky #TEsky
Thrilled to share our new work now published with Kathy Collins, @nogaleslab.bsky.social @berkeleymcb.bsky.social where we investigate this with #cryoEM & biochemistry in 🧪 and cells! #RNAsky #TEsky
June 23, 2025 at 4:19 PM
Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥
Thrilled to share our new work now published with Kathy Collins, @nogaleslab.bsky.social @berkeleymcb.bsky.social where we investigate this with #cryoEM & biochemistry in 🧪 and cells! #RNAsky #TEsky
Thrilled to share our new work now published with Kathy Collins, @nogaleslab.bsky.social @berkeleymcb.bsky.social where we investigate this with #cryoEM & biochemistry in 🧪 and cells! #RNAsky #TEsky
Who is going to make a drawing of Til Scott’s [email protected] #TEsky
November 22, 2024 at 10:58 AM
Who is going to make a drawing of Til Scott’s [email protected] #TEsky
Looking forward to attending my first #ESEB meeting in Barcelona next week #ESEB2025!
Interested in the adaptive potential of transposons? I’ll be presenting my latest work in the Ecological Genomics of Coevolution satellite symposium on Weds 20th - feel free to join!
#TESky #TEworldwide
Interested in the adaptive potential of transposons? I’ll be presenting my latest work in the Ecological Genomics of Coevolution satellite symposium on Weds 20th - feel free to join!
#TESky #TEworldwide
August 14, 2025 at 8:44 AM
Looking forward to attending my first #ESEB meeting in Barcelona next week #ESEB2025!
Interested in the adaptive potential of transposons? I’ll be presenting my latest work in the Ecological Genomics of Coevolution satellite symposium on Weds 20th - feel free to join!
#TESky #TEworldwide
Interested in the adaptive potential of transposons? I’ll be presenting my latest work in the Ecological Genomics of Coevolution satellite symposium on Weds 20th - feel free to join!
#TESky #TEworldwide
And here’s my News & Views on the subject:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cooling down transposon mobility - Nature Plants
Uncontrolled transposable element (TE) mobility can be deleterious to genome integrity. To protect their genomes, plants have evolved intricate silencing mechanisms that put brakes on these mobile ele...
www.nature.com
August 17, 2025 at 10:57 AM
At @eseb.bsky.social #ESEB2025 and want to connect with other researchers working on transposable elements?
Take a look at the #TEWorldwide #TEsky feed:
bsky.app/profile/did:...
Take a look at the #TEWorldwide #TEsky feed:
bsky.app/profile/did:...
August 19, 2025 at 1:01 PM
At @eseb.bsky.social #ESEB2025 and want to connect with other researchers working on transposable elements?
Take a look at the #TEWorldwide #TEsky feed:
bsky.app/profile/did:...
Take a look at the #TEWorldwide #TEsky feed:
bsky.app/profile/did:...
#TEsky Transposon load and RNAi loss synergize to drive intraspecies diversity in Cryptococcus doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
December 18, 2024 at 3:20 PM
#TEsky Transposon load and RNAi loss synergize to drive intraspecies diversity in Cryptococcus doi.org/10.1073/pnas...
#TEsky Tandem LTR-retrotransposon structures are common and highly polymorphic in plant genomes www.researchsquare.com/article/rs-5...
Tandem LTR-retrotransposon structures are common and highly polymorphic in plant genomes
Background LTR-retrotransposons (LTR-RT) are a major component of plant genomes and are a major driver of genome evolution. Most LTR-RT copies in plant genomes are defective elements, found as truncat...
www.researchsquare.com
December 30, 2024 at 4:21 PM
#TEsky Tandem LTR-retrotransposon structures are common and highly polymorphic in plant genomes www.researchsquare.com/article/rs-5...