Dr. Tyler A. Elliott
@transposableman.bsky.social
Transposon obsessed biologist #TEsky. Research Associate in Adamowicz Lab and Linquist Lab @ the U of Guelph
Check out the wealth of TE resources on @tehub.bsky.social https://tehub.org
https://www.tyleraelliott.com/research
Check out the wealth of TE resources on @tehub.bsky.social https://tehub.org
https://www.tyleraelliott.com/research
#TEsky Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA doi.org/10.1266/ggs....
Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA
VANDAL family transposons are DNA transposons prevalent in Arabidopsis and related plants. A notable feature of VANDAL is that they can overcome epige …
doi.org
November 25, 2025 at 1:08 PM
#TEsky Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA doi.org/10.1266/ggs....
#TEsky FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum doi.org/10.1186/s131...
FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum - Mobile DNA
Transposable elements (TEs) are dynamic components of eukaryotic genomes, playing a crucial role in genome evolution and plasticity, particularly in unstable regions such as chromosome ends. In the gl...
doi.org
November 25, 2025 at 1:06 PM
#TEsky FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum doi.org/10.1186/s131...
Reposted by Dr. Tyler A. Elliott
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 24, 2025 at 9:10 PM
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Reposted by Dr. Tyler A. Elliott
I'm recruiting a new master's student for fall 2026 in my lab at Northern Michigan University @bionmu.bsky.social ! Students with interests in evolution of freshwater fish are encouraged to apply. Please see our lab website lizmandeville.github.io and the attached advertisement for more information.
Mandeville Lab
Fish are so delightfully weird. We study the evolutionary genetics and ecology of freshwater fishes, plus a few more things, at Northern Michigan University
lizmandeville.github.io
November 24, 2025 at 2:35 PM
I'm recruiting a new master's student for fall 2026 in my lab at Northern Michigan University @bionmu.bsky.social ! Students with interests in evolution of freshwater fish are encouraged to apply. Please see our lab website lizmandeville.github.io and the attached advertisement for more information.
#TEsky Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa doi.org/10.1093/g3jo...
Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa.
Abstract. Ribosomal DNA (rDNA) occurs as tandem arrays of a repeat unit containing the genes encoding 18S, 5.8S and 28S rRNA separated by spacers. These rR
doi.org
November 24, 2025 at 2:38 PM
#TEsky Copy number and sequence variation in ribosomal DNA and the transposon, Pokey in mutation accumulation lines of Daphnia obtusa doi.org/10.1093/g3jo...
Reposted by Dr. Tyler A. Elliott
Harnessing transposable elements: A new frontier in insect systematics https://pubmed.ncbi.nlm.nih.gov/41167403/
November 1, 2025 at 6:24 AM
Harnessing transposable elements: A new frontier in insect systematics https://pubmed.ncbi.nlm.nih.gov/41167403/
Reposted by Dr. Tyler A. Elliott
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
Reposted by Dr. Tyler A. Elliott
A city of 10 million people now has to move. It won't be the last.
As impossible as it seems, everything happening now will be a footnote to the climate crisis.
As impossible as it seems, everything happening now will be a footnote to the climate crisis.
'Iran’s capital must be moved because the country “no longer has a choice,” President Masoud Pezeshkian said on Thursday in remarks carried by state media, warning that severe ecological strain has made Tehran impossible to sustain'
#Iran 🇮🇷
#Iran 🇮🇷
Iran president says capital move now a necessity as water crisis deepens
Iran’s capital must be moved because the country “no longer has a choice,” President Masoud Pezeshkian said on Thursday in remarks carried by state media, warning that severe ecological strain has mad...
www.iranintl.com
November 21, 2025 at 12:54 PM
A city of 10 million people now has to move. It won't be the last.
As impossible as it seems, everything happening now will be a footnote to the climate crisis.
As impossible as it seems, everything happening now will be a footnote to the climate crisis.
#TEsky Draft Genome Assembly of Parnassius epaphus Provides New Insights into Transposable Elements That Drive Genome Expansion in Alpine Parnassius butterflies doi.org/10.3390/d171...
doi.org
November 21, 2025 at 6:13 PM
#TEsky Draft Genome Assembly of Parnassius epaphus Provides New Insights into Transposable Elements That Drive Genome Expansion in Alpine Parnassius butterflies doi.org/10.3390/d171...
Reposted by Dr. Tyler A. Elliott
Very excited to share my Phd/early post-doc work, out now in Cancer Research! Using multiomic data from multi-site tumors from ovarian cancer patients, we show that the tumors continue to acquire LINE-1 insertions after metastatic spread and find determinants of LINE-1 permissivity in this disease.
Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer
Abstract. L1 retrotransposons are the only protein-coding active transposable elements in the human genome. While typically silenced in normal cells, they are highly expressed in many human epithelial...
aacrjournals.org
November 20, 2025 at 10:54 PM
Very excited to share my Phd/early post-doc work, out now in Cancer Research! Using multiomic data from multi-site tumors from ovarian cancer patients, we show that the tumors continue to acquire LINE-1 insertions after metastatic spread and find determinants of LINE-1 permissivity in this disease.
Reposted by Dr. Tyler A. Elliott
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutati...
www.biorxiv.org
November 4, 2025 at 6:17 PM
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dr. Tyler A. Elliott
Excited to share our new @narjournal.bsky.social paper!
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
October 18, 2025 at 6:59 AM
Excited to share our new @narjournal.bsky.social paper!
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Reposted by Dr. Tyler A. Elliott
Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The virulence gene ToxB is both amplified and disrupted by transposons in the wheat pathogen Pyrenophora tritici-repentis
### Competing Interest Statement
The authors have declared no competing interest.
Agriculture and Agri-Food Canada, https://ror.org/051dzs374
Alberta Grain
Saskatchewan Wheat Development Commissio...
www.biorxiv.org
November 18, 2025 at 4:22 PM
Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dr. Tyler A. Elliott
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Dr. Tyler A. Elliott
Seahorses have a unique sex role reversal with male pregnancy involving a brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity 🧪 www.nature.com/articles/s41...
Cellular and molecular mechanisms of seahorse male pregnancy - Nature Ecology & Evolution
Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellu...
www.nature.com
November 17, 2025 at 8:52 AM
Seahorses have a unique sex role reversal with male pregnancy involving a brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity 🧪 www.nature.com/articles/s41...
Reposted by Dr. Tyler A. Elliott
I recently discovered Conventional Comments (conventionalcomments.org) for providing a pseudo-standard set of labels for feedback and just tried it for an article review and it was really helpful to specify issues vs. thoughts vs. suggestions, etc. Hopefully it's helpful for the authors too!
November 17, 2025 at 3:52 PM
I recently discovered Conventional Comments (conventionalcomments.org) for providing a pseudo-standard set of labels for feedback and just tried it for an article review and it was really helpful to specify issues vs. thoughts vs. suggestions, etc. Hopefully it's helpful for the authors too!
Reposted by Dr. Tyler A. Elliott
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
Environmental fluctuations influence heritable phenotypes through complex molecular mechanisms. In zebrafish (Danio rerio), the interplay between temperature variation, transposable element (TE) activ...
www.biorxiv.org
November 16, 2025 at 10:18 AM
🚨 New preprint alert!
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Our latest work from @immler.bsky.social lab 🐟🧬
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells
#TESky #TE #piRNA #miRNA #zebrafish #DanioDigest
🔗 Read here www.biorxiv.org/content/10.1...
A thread 🧵...
Reposted by Dr. Tyler A. Elliott
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells https://www.biorxiv.org/content/10.1101/2025.11.15.688619v1
November 16, 2025 at 3:32 AM
Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells https://www.biorxiv.org/content/10.1101/2025.11.15.688619v1
Reposted by Dr. Tyler A. Elliott
It's out, Minos transgenesis in the pantry moth by
@donyaniyaz.bsky.social
@lucalivraghi.bsky.social
High efficient, glowing eye and silk gland markers
peerj.com/articles/202...
@peerj.bsky.social
@donyaniyaz.bsky.social
@lucalivraghi.bsky.social
High efficient, glowing eye and silk gland markers
peerj.com/articles/202...
@peerj.bsky.social
November 12, 2025 at 2:40 PM
It's out, Minos transgenesis in the pantry moth by
@donyaniyaz.bsky.social
@lucalivraghi.bsky.social
High efficient, glowing eye and silk gland markers
peerj.com/articles/202...
@peerj.bsky.social
@donyaniyaz.bsky.social
@lucalivraghi.bsky.social
High efficient, glowing eye and silk gland markers
peerj.com/articles/202...
@peerj.bsky.social
Reposted by Dr. Tyler A. Elliott
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
November 15, 2025 at 5:23 PM
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
Reposted by Dr. Tyler A. Elliott
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein
Non-LTR retrotransposon proteins copy their RNA template into a genome via coordinated nicking and reverse transcriptase activities of target-primed reverse transcription. Mechanisms by which the firs...
www.science.org
November 13, 2025 at 8:05 PM
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Reposted by Dr. Tyler A. Elliott
Unfortunately has been my experience in so many different social and subculture circles.
“Oh, that dude was inappropriate to your young friend? But he’s so fun to party with…”
Lots of people show their true colours when allegations emerge about someone they know personally or somehow benefit from.
“Oh, that dude was inappropriate to your young friend? But he’s so fun to party with…”
Lots of people show their true colours when allegations emerge about someone they know personally or somehow benefit from.
Aside from whatever is in these files about trump I think we’re going to get a crash course in just how grim men truly are across the board. From the rarified air of academia, through to the muck of politics, at every level dudes were ok with Jeff the predator as long as they were getting theirs.
In 2023, Chomsky told WSJ about his relationship with Epstein: “First response is that it is none of your business. Or anyone’s. Second is that I knew him and we met occasionally.”
Epstein: you are of course welcome to use apt in new york with your new leisure time, or visit new Mexico again
Epstein: you are of course welcome to use apt in new york with your new leisure time, or visit new Mexico again
November 13, 2025 at 7:52 PM
Unfortunately has been my experience in so many different social and subculture circles.
“Oh, that dude was inappropriate to your young friend? But he’s so fun to party with…”
Lots of people show their true colours when allegations emerge about someone they know personally or somehow benefit from.
“Oh, that dude was inappropriate to your young friend? But he’s so fun to party with…”
Lots of people show their true colours when allegations emerge about someone they know personally or somehow benefit from.
Reposted by Dr. Tyler A. Elliott
I'm excited to introduce our new workflow for detecting endogenous viral elements - HI-FEVER. 🖥️🧬
academic.oup.com/bioinformati...
🧵
Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!
academic.oup.com/bioinformati...
🧵
Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!
HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements
AbstractSummary. Endogenous viral elements (EVEs) offer valuable insights into virus and host evolution, but their detection remains computationally and bi
academic.oup.com
November 13, 2025 at 11:14 AM
I'm excited to introduce our new workflow for detecting endogenous viral elements - HI-FEVER. 🖥️🧬
academic.oup.com/bioinformati...
🧵
Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!
academic.oup.com/bioinformati...
🧵
Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!
Reposted by Dr. Tyler A. Elliott
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
Insertion of an invading retrovirus regulates a novel color trait in swordtail fish
For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...
shorturl.at
November 12, 2025 at 8:34 PM
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A