🔬 A study from The Institute & Lady Davis Institute uncovers new mechanisms of osteosarcoma, the most common bone cancer in youth. Toward more targeted therapies.
@cusm-muhc.bsky.social @healthsciences.mcgill.ca
➡️ rimuhc.ca/-/genomic-st...

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

The @terryfoxresearch.bsky.social @marathonofhope.bsky.social cancer centres network has now processed over 10,000 patient genomic profiles, with over 5,300 complete clinical data sets, and now comprises 50 member institutions. A truly national effort inspired by an inspirational Canadian. 🇨🇦 🤯

Amazing scientist and team !! Many congrats 🎉

Thank you @ccsresearch.bsky.social and @terryfoxresearch.bsky.social ! We often hear the phrase "divide and conquer" but for pediatric/AYA and rare cancers we evidently need to #unite_and_conquer; patient samples, funding and like-minded people. Thank you for making me part of this partnership 💛

Epigenetics Update - Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation bit.ly/47khG2x

Hsiang-Ying Lee and Nian Liu in Cell

#Epigenetics #Bivalency #HisMods #Transposons
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High-resolution insights without cell sorting; epigenometech.com

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk #sarcomas

www.nature.com/articles/s41...

Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.

www.nature.com/articles/s41...

On this final day of Sarcoma Awareness Month, we're sharing a breakthrough that brings new hope to patients with osteosarcoma – the same cancer that set Terry Fox on his Marathon of Hope.

📖 Read more: www.tfri.ca/updates/news...

@terryfoxfoundation.bsky.social @ccsresearch.bsky.social @mcgill.ca