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Reposted by Yahaya Yabo

Anna Golebiewska @annagolebiewska.bsky.social · 24d

Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas

Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...

www.biorxiv.org

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Yahaya Yabo @yahayayabo.bsky.social · Jul 5

Thanks Roman.

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Reposted by Yahaya Yabo

Nature Reviews Cancer @natrevcancer.nature.com · Jul 4

NEW content online!

Combining spatial transcriptomics and AI to enhance brain tumour diagnosis

Nature Reviews Cancer, Published online: 04 July 2025; doi:10.1038/s41568-025-00851-6In this Tools of the Trade article, Yahaya A. Yabo describes the development of neuropathology spatial transcriptomic analysis (NePSTA), an artificial intelligence (AI)-based tool to identify and map unique spatial patterns within tissues.

www.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · Jul 5

Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...

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Reposted by Yahaya Yabo

Roman Sankowski @rsankowski.bsky.social · May 20

#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com

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Reposted by Yahaya Yabo

Omer Ali Bayraktar @bayraktarlab.bsky.social · May 16

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

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Reposted by Yahaya Yabo

Stein Aerts @steinaerts.bsky.social · May 16

Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

www.biorxiv.org

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Reposted by Yahaya Yabo

Masashi Nomura @masashi-nomura.bsky.social · May 9

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...

The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

www.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · May 6

Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉

Spencer S Watson @drspencerwatson.bsky.social · May 5

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma!
doi.org/10.1093/neuo...

Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap

AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

doi.org

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Reposted by Yahaya Yabo

Nature Biotechnology @natbiotech.nature.com · Apr 22

Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b

Putting cancer immunotherapy into spatial context in the clinic - Nature Biotechnology

Spatial omics technologies offer insights into the organization of cellular and molecular components and their interactions within the tumor ecosystem. Overcoming the key challenges to integrating the...

go.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · Apr 7

The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq

Dieter Henrik Heiland @heilandhenrik.bsky.social · Apr 7

We had an amazing lab retreat Spring 2025! Best team of the world!

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Yahaya Yabo @yahayayabo.bsky.social · Apr 2

Congratulations to Annette. Well deserved.

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Reposted by Yahaya Yabo

Emre Kocakavuk @ekocakavuk.bsky.social · Feb 19

📣 Open computational PhD & Postdoc positions!

Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus

📢 Please RT (what's the bsky equivalent here?) and distribute !

👇A quick instruction on how to apply

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Reposted by Yahaya Yabo

Nature @nature.com · Feb 20

Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas

https://go.nature.com/434f4ns

GABAergic neuron-to-glioma synapses in diffuse midline gliomas - Nature

Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.

go.nature.com

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Reposted by Yahaya Yabo

EANO @eanoassociation.bsky.social · Feb 4

🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙

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Yahaya Yabo @yahayayabo.bsky.social · Jan 31

Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social

tobiw2024.bsky.social @tobiw2024.bsky.social · Jan 30

Happy to present our newest work cross-comparing CAR T cells, CAR NK cells and CAR macrophages. Thanks to Thomas Look and our amazing collaborators Roman Sankowski @rsankowski.bsky.social César Nombela Arrieta, Berend Snijder, Steve Pascolo
www.cell.com/cell-reports...

CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines

This comparative analysis of CAR T cells, CAR NK cells, and CAR macrophages in glioma mouse models by Look et al. reveals distinct features for each cell type, emphasizes the benefit of combinatorial ...

www.cell.com

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Reposted by Yahaya Yabo

MILO Lab @milolab.bsky.social · Jan 30

Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics

🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs

t.co/GmA9MLNKy1

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Reposted by Yahaya Yabo

MILO Lab @milolab.bsky.social · Jan 30

Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!

www.instagram.com/the_milolab/...

Login • Instagram

Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.

www.instagram.com

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Reposted by Yahaya Yabo

MILO Lab @milolab.bsky.social · Jan 30

Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!

www.nature.com/articles/s43...

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

www.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · Jan 30

Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.

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Reposted by Yahaya Yabo

Roman Sankowski @rsankowski.bsky.social · Jan 30

New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social

www.nature.com/articles/s43...

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

www.nature.com

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Reposted by Yahaya Yabo

Barbara Marte @barbmarte.bsky.social · Jan 16

new out in Nature: lovely paper www.nature.com/articles/s41...

Brain-wide neuronal circuit connectome of human glioblastoma - Nature

Nature - Brain-wide neuronal circuit connectome of human glioblastoma

www.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · Jan 15

Congratulations for the well deserved award. You are indeed an inspiration to many of us.

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Reposted by Yahaya Yabo

Roel Verhaak @roelverhaak.bsky.social · Jan 3

Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...

Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature

A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...

www.nature.com

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Yahaya Yabo @yahayayabo.bsky.social · Dec 13

Awesome work.👌

Fabian Theis @fabiantheis.bsky.social · Dec 12

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1