Roman Sankowski
@rsankowski.bsky.social
Neuropathologist | #clinicianScientist | #singleCell | Neuro-immunologist | Neuro-oncologist @ University Clinic of Freiburg
Dad | Foodie | hobby barista | views my own
Dad | Foodie | hobby barista | views my own
Pinned
Roman Sankowski
@rsankowski.bsky.social
· May 20
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
Reposted by Roman Sankowski
Selecting the optimal cell migration assay: fundamentals and practical guidelines www.nature.com/articles/s4...
February 7, 2026 at 3:15 PM
Selecting the optimal cell migration assay: fundamentals and practical guidelines www.nature.com/articles/s4...
Reposted by Roman Sankowski
Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 7, 2026 at 3:00 AM
Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Roman Sankowski
Reposted by Roman Sankowski
Childhood brain tumors instruct cranial hematopoiesis and immunotolerance @natgenet.nature.com
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...
February 3, 2026 at 10:36 PM
Childhood brain tumors instruct cranial hematopoiesis and immunotolerance @natgenet.nature.com
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...
Classic lying with charts. #propaganda
February 3, 2026 at 5:24 PM
Classic lying with charts. #propaganda
Reposted by Roman Sankowski
chatomics! new blog post: Understanding prcomp() center and scale Arguments for Single-Cell RNA-seq PCA divingintogeneticsandgenomics.com/post/unders...
February 3, 2026 at 2:45 PM
chatomics! new blog post: Understanding prcomp() center and scale Arguments for Single-Cell RNA-seq PCA divingintogeneticsandgenomics.com/post/unders...
Reposted by Roman Sankowski
PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3′ end sequencing data link.springer.com/article/10....
github github.com/APAexplorer...
github github.com/APAexplorer...
February 2, 2026 at 3:15 PM
PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3′ end sequencing data link.springer.com/article/10....
github github.com/APAexplorer...
github github.com/APAexplorer...
Reposted by Roman Sankowski
Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration - Journal of Molecular Evolution
The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthol...
link.springer.com
February 3, 2026 at 8:41 AM
Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Roman Sankowski
1/12 What is “CHIP” in blood sequencing, and why does it mess up mutation calls?
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
January 31, 2026 at 2:45 PM
1/12 What is “CHIP” in blood sequencing, and why does it mess up mutation calls?
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Important insights into the tumor #microenvironment of spinal bone #metastases.
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases
This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing
niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy
resistance. Combine...
www.cell.com
January 31, 2026 at 7:02 PM
Important insights into the tumor #microenvironment of spinal bone #metastases.
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
Reposted by Roman Sankowski
The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes
www.unilad.com/news/health/...
www.unilad.com/news/health/...
Scientists successfully achieve 'permanent disappearance of pancreatic cancer' in new study for cure
The team searching for a pancreatic cancer cure included the ‘renowned Dr Mariano Barbacid,' a legend in the cancer research field
www.unilad.com
January 30, 2026 at 9:31 PM
The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes
www.unilad.com/news/health/...
www.unilad.com/news/health/...
Reposted by Roman Sankowski
Don was taken into custody by federal agents last night in Los Angeles.
January 30, 2026 at 12:58 PM
Don was taken into custody by federal agents last night in Los Angeles.
Reposted by Roman Sankowski
The arrest of Don Lemon is textbook fascism—a brazen attempt to silence reporting on a criminal regime. Stand up for Don, because our rights stand and fall with those of courageous journalists throughout this country.
January 30, 2026 at 7:18 PM
The arrest of Don Lemon is textbook fascism—a brazen attempt to silence reporting on a criminal regime. Stand up for Don, because our rights stand and fall with those of courageous journalists throughout this country.
Reposted by Roman Sankowski
January 30, 2026 at 9:33 AM
Reposted by Roman Sankowski
Vous en avez marre des GAFAM et de l’ultra dépendance aux services US ? Voici des solutions, toutes présentes dans notre fiction en accès libre « GAFAM : 24h dans la peau d’un repenti ».
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
January 24, 2026 at 8:52 AM
Vous en avez marre des GAFAM et de l’ultra dépendance aux services US ? Voici des solutions, toutes présentes dans notre fiction en accès libre « GAFAM : 24h dans la peau d’un repenti ».
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Does the neuronal ‘aggregome’ explain neurodegeneration? A ne study from the Wyss-Coray lab suggest so using a novel methodology
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature
Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.
www.nature.com
January 21, 2026 at 9:41 PM
Does the neuronal ‘aggregome’ explain neurodegeneration? A ne study from the Wyss-Coray lab suggest so using a novel methodology
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Important new findings on #choroid #plexus #macrophages - good Job Simone Brioschi and Marco Colonna!
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
The choroid plexus is a vital brain ventricular organ that produces cerebrospinal fluid. This study shows how developmental origins and local niches shape the specialization of choroid plexus macropha...
www.nature.com
January 21, 2026 at 9:34 PM
Important new findings on #choroid #plexus #macrophages - good Job Simone Brioschi and Marco Colonna!
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Coo study showing how pregnancy reduces #MS relapses by 80%. Mechanisms: Specialized brainstem neurons detect the fetal signal GDF-15 and specifically dampen inflammatory cells through the sympathetic nervous system—preventing their entry into the CNS.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology
Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...
www.nature.com
January 18, 2026 at 11:48 AM
Coo study showing how pregnancy reduces #MS relapses by 80%. Mechanisms: Specialized brainstem neurons detect the fetal signal GDF-15 and specifically dampen inflammatory cells through the sympathetic nervous system—preventing their entry into the CNS.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interesting approach looking at animal origins as driven by a smartphone-like animalOS. So can I put a catOS into a mouse?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 15, 2026 at 12:23 PM
Interesting approach looking at animal origins as driven by a smartphone-like animalOS. So can I put a catOS into a mouse?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
It’s Kind of cute and hard to imagine in Europe or the US..
Prime Minister Sanae Takaichi of Japan and President Lee Jae Myung of South Korea jammed to BTS and “KPop Demon Hunters,” in a display meant to show warming ties between their countries at a time of deep geopolitical and economic uncertainty.
Watch the Leaders of Japan and South Korea Jam to K-pop on the Drums
Prime Minister Sanae Takaichi of Japan and President Lee Jae Myung of South Korea played along to BTS and “KPop Demon Hunters,” in a display meant to show warming ties.
trib.al
January 14, 2026 at 12:35 PM
It’s Kind of cute and hard to imagine in Europe or the US..
This study shows mechanistic links between #multiple #sclerosis and #EBV Epstein-Barr Virus that reveals..
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 14, 2026 at 9:17 AM
This study shows mechanistic links between #multiple #sclerosis and #EBV Epstein-Barr Virus that reveals..
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Reposted by Roman Sankowski
Prof. Bo Peng’s work is truly inspiring. His research on microglia replacement shows how fundamental neuroimmunology can be translated into real clinical impact. I listened to the seminar on my way to the clinic this morning and was very glad to be introduced to his work.👏🏻
youtu.be/wt4JkX3fNKg?...
youtu.be/wt4JkX3fNKg?...
European Microglia Webinar Series, by Prof. Bo Peng (2026-01-13)
YouTube video by Achucarro Basque Center for Neuroscience
youtu.be
January 14, 2026 at 9:04 AM
Prof. Bo Peng’s work is truly inspiring. His research on microglia replacement shows how fundamental neuroimmunology can be translated into real clinical impact. I listened to the seminar on my way to the clinic this morning and was very glad to be introduced to his work.👏🏻
youtu.be/wt4JkX3fNKg?...
youtu.be/wt4JkX3fNKg?...
Reposted by Roman Sankowski
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
open.substack.com/pub/drericdi...
open.substack.com/pub/drericdi...
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
Anti-vaxxers don't want you to know about off-target benefits.
open.substack.com
January 14, 2026 at 5:35 AM
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
open.substack.com/pub/drericdi...
open.substack.com/pub/drericdi...