#BioPhyChrom25 gala dinner at the 14th century #Hospitium venue in York, and @agnesnoy.bsky.social talk. Lots of discussion and ideas for BioPhyChrom2027… Great vibes and atmosphere!
@biophychrom.bsky.social @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social 🧬

Our community letter on #FAIR principles in #moleculardynamics simulations has been published on @naturemethods.bsky.social 🎉

This is one of the conferences where I have genuinely learned more. Delighted to contribute to this vision article.

Were you interested in our last paper published in Phys. Rev. Lett. (with Matthew Burman at the University of York) but found it too hard to follow? Then, look at the piece from @sciencex.bsky.social where it is explained in more plain terms with the help of Ingrid Fadelli

And finally, we described melting bubbles in highly overtwisted DNA, once again in agreement with biochemical assays from Zechiedrich's lab (6/6)

We also describe the dynamics and diffusion of supercoils. Big end-to-end fluctuations are caused by supercoil reorganization as described by
Lipfert and @ecarlon.bsky.social labs (5/6)

This state converges to tip-bubbles as tension increases in agreement with previous oxDNA simulations from Doye and Louis labs 👇 (again, bubbles in red) (4/6)

We find a new state in negative supercoiling and minimal tension where bubbles form in AT-rich regions irrespective of the underlying DNA topology. They were already detected by Zechiedrich's lab using biochemical assays (bubbles in red) 👇 (3/6)

We provide the conformational phase diagram. We map the regime where bubbles and supercoils are excluded from each other in moderate levels of supercoiling. We name it 'elastic' because it was deduced by rod elastic models (2/6)

Our last paper just appeared in Physical Review Letters. We studied how linear DNA is distorted by torsion and tension using all-atom simulations. Excellent work from Matthew Burman's EPSRC-funded PhD. Thanks to N8 CIR and HecBiosim for computational resources
doi.org/10.1103/Phys...
See thread 👇

But still is very good! Well done! I have never won any running prize, apart from being in the top ten from the last... 🙃

I am very excited that I will participate in this workshop!

Registration is now open for The Biology and Physics of Prokaryotic Chromosomes meeting in York, UK. 16-19 September 2025