Ah-Ram Kim
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ahramkim.bsky.social
Ah-Ram Kim
@ahramkim.bsky.social
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Reposted by Ah-Ram Kim
carolynbertozzi.bskyverified.social
Multidisciplinary training, over time, produces the highest impact people

www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Reposted by Ah-Ram Kim
fly-broadcast.bsky.social
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATP
#Drosophila
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATP #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 14, 2025 at 9:23 AM
Reposted by Ah-Ram Kim
biorxiv-bioinfo.bsky.social
A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome https://www.biorxiv.org/content/10.1101/2025.10.10.681672v1
October 12, 2025 at 6:47 PM
Reposted by Ah-Ram Kim
aixbiobot.bsky.social
A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome [new]
Kinase docking on TFs predicted; novel homeodomain motif found.
Figure 2 Figure 3 Figure 4 Figure 5
October 12, 2025 at 7:23 PM
Reposted by Ah-Ram Kim
perrimonlab.bsky.social
New paper: Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer
Liu, Miao, Wang, Ezequiel, Kim, Zhang, Sun, Binari, Asara, Yanhui Hu, Goncalves, Janowitz, Perrimon
doi: doi.org/10.1101/2025...
Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer
Paraneoplastic syndromes arise when tumor-derived cytokines reprogram distant organs. Although mediators such as Interleukin-6 have been implicated, how these signals impair host organ function remain...
doi.org
October 4, 2025 at 1:13 PM
Reposted by Ah-Ram Kim
perrimonlab.bsky.social
New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon
bioRxiv 2025.10.10.681672; doi: doi.org/10.1101/2025...
A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Protein kinases orchestrate cellular processes through phosphorylation, yet the structural basis for their specific binding partner interactions remains largely unmapped. Here, we present a structure-...
doi.org
October 12, 2025 at 8:51 PM
Reposted by Ah-Ram Kim
danafarbernews.bsky.social
A new study in @cp-molcell.bsky.social by @danafarber.bsky.social’s Mikołaj Słabicki, PhD, Benjamin Ebert, MD, PhD, and Eric Fischer, PhD, reports a systematic screen of 9,000 zinc fingers revealing 38 new CRBN-recruited degrons, expanding the ZF proteome map to guide drug design. bit.ly/41XoG1Q
New research from Dana-Farber Cancer Institute
August 26, 2025 at 2:30 PM
Reposted by Ah-Ram Kim
peiferlabunc.bsky.social
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu… https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team
August 23, 2025 at 12:18 PM
Reposted by Ah-Ram Kim
flybase.bsky.social
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 15, 2025 at 12:45 PM
Reposted by Ah-Ram Kim
jakbosch.bsky.social
I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️.
Thread below🧵
1/8
www.biorxiv.org/content/10.1...
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...
www.biorxiv.org
July 11, 2025 at 2:51 PM
ahramkim.bsky.social
FlyPhoneDB2: A Computational Framework for Analyzing Cell-Cell Communication in Drosophila scRNA-seq Data Integrating AlphaFold-Multimer Predictions
www.csbj.org/article/S200...
FlyPhoneDB2: A Computational Framework for Analyzing Cell-Cell Communication in Drosophila scRNA-seq Data Integrating AlphaFold-Multimer Predictions
Cell-cell communication (CCC) plays a critical role in the physiological regulation of organisms and has been implicated in numerous diseases. Previously, we introduced FlyPhoneDB, a tool designed to ...
www.csbj.org
June 25, 2025 at 9:28 PM
Reposted by Ah-Ram Kim
ebi.embl.org
New impact case study outlines the impressive economic & scientific value of UniProt - the world-leading open data resource for protein sequence & functional information.

Users save up to 219 hours per year, equivalent to net benefits of up to €5,475 per user.

www.ebi.ac.uk/about/news/a...
Measuring the value and impact of UniProt
Case study shows the economic value and impact of UniProt, showing estimated annual gains of up to €5,475 per user.
www.ebi.ac.uk
June 25, 2025 at 3:24 PM
ahramkim.bsky.social
xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins
www.nature.com/articles/s41...
xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins - Nature Methods
xTrimo protein general language model (xTrimoPGLM) is a unified pretraining framework and foundation model designed for various protein-related tasks, including protein understanding and generation or...
www.nature.com
April 8, 2025 at 10:45 AM
ahramkim.bsky.social
Far-red fluorescent genetically encoded calcium ion indicators
www.nature.com/articles/s41...
Far-red fluorescent genetically encoded calcium ion indicators - Nature Communications
Genetically-encoded indicators with more red-shifted excitation and emission wavelengths are advantageous for in vivo imaging. Here, Dalangin et al. report the engineering of far-red fluorescent Ca2+ ...
www.nature.com
April 8, 2025 at 10:33 AM
ahramkim.bsky.social
dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening
www.nature.com/articles/s41...
dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening - Nature Communications
Arrayed and pooled high-throughput screening is crucial for drug discovery and CRISPR functional genomics. Here, the authors present dFLASH; a dual FLuorescent transcription factor Activity Sensor for...
www.nature.com
April 8, 2025 at 10:30 AM