Nature Reviews Genetics, Published online: 09 January 2026; doi:10.1038/s41576-025-00926-yIn this Tools of the Trade article, Yubao Cheng discusses the development of RAEFISH (reverse-padlock amplicon-encoding fluorescence in situ hybridization), a method that enables spatial transcriptomics with both single-molecule spatial resolution and genome-wide coverage.

Researchers believe they could be representations of extraterrestrial beings that visited humanity in the past.

NASA spent years and billions of dollars collecting Martian samples to bring home. Now they might be stranded

Nature Reviews Genetics, Published online: 06 January 2026; doi:10.1038/s41576-025-00923-1The complex and repetitive nature of centromeres has historically posed challenges to their genomic assembly and functional understanding, which are now being overcome with long-read sequencing. This Review discusses recent genomic and epigenomic insights into human centromere biology that have positioned the field for future studies of centromere structure in chromosome biology and human disease.

Nature - Technical advances allow researchers to trace the genetic changes that occur over time.

The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...

Abstract. A lack of recombination in the heterogametic sex between parts or all of newly evolving sex chromosomes results in the gradual accumulation of de

Certain genes, chromosomes, organelles, or entire sets of chromosomes can bias their transmission to the next generation, propagating themselves at the expense of the rest of the genome. Referred to …

Background Whole-genome sequencing efforts, have during the past decade, unveiled the central role of genomic rearrangements—such as chromosomal inversions—in evolutionary processes, including local a...

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Background Whole-genome sequencing efforts, have during the past decade, unveiled the central role of genomic rearrangements—such as chromosomal inversions—in evolutionary processes, including local a...