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Reposted by Alice Maestri

Eduardo Rocha @epcrocha.bsky.social · Sep 8

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

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Alice Maestri @alicemaestri.bsky.social · 26d

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.

Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!

INSTITUT PASTEUR - Technicien de recherche Microbiologie H/F

emploi.pasteur.fr

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Alice Maestri @alicemaestri.bsky.social · Apr 14

Brava Claudia!!

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Reposted by Alice Maestri

Eduardo Rocha @epcrocha.bsky.social · Apr 14

Great collaboration with @fredoleroux.bsky.social . Kudos for everyone, esp. Charles Bernard & Yannick Labreuche. Thanks to the funders and @pasteur.fr @cnrsbiologie.bsky.social @umontreal.ca @sbroscoff.bsky.social Here's the paper in OA: doi.org/10.1093/isme...

Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages

Abstract. The host range of a bacteriophage—the diversity of hosts it can infect—is central to understanding phage ecology and applications. Whereas most w

doi.org

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Reposted by Alice Maestri

Eduardo Rocha @epcrocha.bsky.social · Mar 27

Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective!
Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.

Nature Reviews Microbiology @natrevmicro.nature.com · Mar 27

New online! Genetics, ecology and evolution of phage satellites

Genetics, ecology and evolution of phage satellites

Nature Reviews Microbiology, Published online: 27 March 2025; doi:10.1038/s41579-025-01156-zIn this Review, Penadés et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the evolution of other mobile genetic elements and their host bacteria.

www.nature.com

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Reposted by Alice Maestri

Olaya Rendueles @olayarendueles.bsky.social · Apr 9

Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...

Phage therapy for Klebsiella pneumoniae: Understanding bacteria–phage interactions for therapeutic innovations

Klebsiella pneumoniae (KP) is a Gram-negative bacterium that commonly resides in the human gastrointestinal tract and can also act as an opportunistic pathogen and cause extra-intestinal infections. K...

doi.org

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Reposted by Alice Maestri

Multi-Defence @multidefence.bsky.social · Apr 10

🔬 Three fronts in bacterial defense!
At EMBO symposium this week in Paris, our PIs showcased:
• @mfwhite2.bsky.social: cyclic nucleotide defence signaling
• Prof. Stineke Van Houte: prophage warfare in P. aeruginosa
• Prof. Tim Blower: autoregulating toxins & phage defence

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Reposted by Alice Maestri

Ellinor Alseth @ellinoralseth.bsky.social · Apr 10

Mystique is here! When I started my position at @cmdi.bsky.social there were no readily available phage against my A. baumannii focal strain. The solution? Finding my own phage ofc. Mystique is a broad host range Acinetobacter phage, and I'm thrilled to see this work out today #PhageSky 🧪🦠

Mystique, a broad host range Acinetobacter phage, reveals the impact of culturing conditions on phage isolation and infectivity

Author summary Bacterial infections caused by Acinetobacter baumannii are a major global health concern due to high antibiotic resistance, earning it a critical priority pathogen ranking by the WHO. P...

journals.plos.org

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Reposted by Alice Maestri

Jamie Hall @jpjhall.bsky.social · Feb 18

I'm delighted to announce that the 2025 @microbiologysociety.org meeting on "Understanding and predicting microbial evolutionary dynamics" will be held in Liverpool 26-27 November 2025! Abstract submission will open soon... #microsky 🧪🧫🦠 microbiologysociety.org/event/societ...

Understanding and predicting microbial evolutionary dynamics - 2025 meeting

microbiologysociety.org

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Reposted by Alice Maestri

Lingchen He 何灵尘 @lingchenhe.bsky.social · Feb 13

@jonaszpatkowski.bsky.social and I pinpointed tail piracy as a new mechanism of horizontal gene transfer and explained the wide spread of cf-PICIs among different bacterial species and viromes.

Tiago Costa @tcostalab.bsky.social · Feb 12

New work from the lab with @jrpenades.bsky.social! We discovered a biological entity that spreads among different bacterial species by hijacking tails from various phages. This finding has major translational applications due to its broad host range. More news soon!
shorturl.at/kRJqE

Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization

Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), ...

shorturl.at

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Reposted by Alice Maestri

Aude Bernheim @audeber.bsky.social · Jan 13

👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder.

We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things.

Please answer wt preprints/papers with new systems or mail/git them to us. 🙏

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Reposted by Alice Maestri

Jamie Hall @jpjhall.bsky.social · Oct 31

Happy Hallowe’en! We made a spooky AMR vs bacteriophage comic free to download and use. Take a look and give @andthemicrobes.bsky.social a follow!

(There’s even a prequel on plasmids and bacterial diversity!)

🎃🦠🧬👻

bsky.app/profile/andt...

Luna & Simon - Adventures in Science! @andthemicrobes.bsky.social · Oct 31

🎃 HAPPY HALLOWE'EN! 🎃

Do you know what's scarier than zombies and werewolves?

ANTIBIOTIC RESISTANCE! Join Luna and Simon as they spend Hallowe'en night exploring the science of microbes, and the bacteriophages out to destroy them!

www.andthemicrobes.org/phage

#sciencecomics #antibioticresistance

- NIGHT OF THE KILLER PHAGE! — And The Microbes

www.andthemicrobes.org

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Alice Maestri @alicemaestri.bsky.social · Oct 23

Congratulations Josie!! 😍

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Reposted by Alice Maestri

Ellinor Alseth @ellinoralseth.bsky.social · Oct 21

Hi to all my new (and old) followers! So fun to see more people joining us here. I'm currently an independent post-doc and evolutionary microbiologist at Georgia Tech in the US, studying Acinetobacter baumannii – phage dynamics. Welcome!
www.biorxiv.org/content/10.1...

Environmental differences impact Acinetobacter baumannii phage isolation and infectivity

With the global rise of antimicrobial resistance, phage therapy is increasingly re-gaining traction as a strategy to treat bacterial infections. For phage therapy to be successful however, we first ne...

www.biorxiv.org

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Reposted by Alice Maestri

Eduardo Rocha @epcrocha.bsky.social · Oct 15

Our study on the (huge) variations in transformation rates is now out in OA! Key question: why are so many strains non-transformable if the many recent transitions to non-transformability seem deleterious? doi.org/10.1371/jour...

Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species

Bacterial species exhibit large variations in their transformation rates. This study of Legionella pneumophila and Acinetobacter baumannii shows that their transformation rates evolve by sudden quick ...

doi.org

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Alice Maestri @alicemaestri.bsky.social · Sep 6

The view from my new workplace :)

Can't possibly be happier to be working on phage satellites with @jmouradesousa.bsky.social , @epcrocha.bsky.social and the team!

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Alice Maestri @alicemaestri.bsky.social · Aug 18

Throughout this time I've also been very lucky to meet fantastic friends and colleagues that made everything so much better🧡

An important chapter of my life and career comes to an end - now I'm ready and excited for the next!

Alice Maestri @alicemaestri.bsky.social · Aug 18

Thank you to my PhD supervisor Edze Westra for everything - it has been great working with you! I'll always keep treasure of what I learnt from you and your team over these years!

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Alice Maestri @alicemaestri.bsky.social · Aug 18

My official PhD graduation last month was the closing step of an incredible journey, marking the end of my time in Cornwall!

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Multi-Defence @multidefence.bsky.social · Jul 23

We have another position advertised 😃 with @taylorlabgroup.bsky.social in Bath to understand the regulation of multi layered defence systems!! You can apply at www.bath.ac.uk/jobs/Vacancy...
Applications close on 9th September.

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Reposted by Alice Maestri

Tiffany Taylor @taylorlabgroup.bsky.social · Aug 13

New paper looking at the spread of CRISPR-Cas in bacterial populations. Congratulations to @josie-e.bsky.social on her first, first author paper 🎉! Check out her brilliant thread below. Happy to see this work out in the wild.

Josie Elliott @josie-e.bsky.social · Aug 13

Excited to share my 1st paper with
@bridgetwatson.bsky.social @taylorlabgroup.bsky.social Edze Westra Sylvain Gandon & David McLeod academic.oup.com/ismej/articl... where we ask “when would using a defence system (CRISPR-Cas) be selectively advantageous over mutations that block phage binding?”1/10

Conditions for the spread of CRISPR-Cas immune systems into bacterial populations

Abstract. Bacteria contain a wide variety of innate and adaptive immune systems which provide protection to the host against invading genetic material, inc

academic.oup.com

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Reposted by Alice Maestri

Josie Elliott @josie-e.bsky.social · Aug 13

Excited to share my 1st paper with
@bridgetwatson.bsky.social @taylorlabgroup.bsky.social Edze Westra Sylvain Gandon & David McLeod academic.oup.com/ismej/articl... where we ask “when would using a defence system (CRISPR-Cas) be selectively advantageous over mutations that block phage binding?”1/10

Conditions for the spread of CRISPR-Cas immune systems into bacterial populations

Abstract. Bacteria contain a wide variety of innate and adaptive immune systems which provide protection to the host against invading genetic material, inc

academic.oup.com

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Reposted by Alice Maestri

Michael Brockhurst @brockhurstlab.bsky.social · Jul 31

1st foray into T6SS with talented @mermanchester.bsky.social fellow Will Smith: eco-evo models and experimental evolution show how and why producing multiple toxins blocks resistance evolution (even though cross-resistance can evolve under single-toxin attack) www.biorxiv.org/content/10.1...

Multiplicity of Type 6 Secretion System toxins limits the evolution of resistance

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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Reposted by Alice Maestri

Mark A. Hanson @hansonmark.bsky.social · Aug 8

Hiring a bioinformatician at @uniofexeter.bsky.social to work with the Exeter sequencing facility. Please spread the word!

jobs.exeter.ac.uk/hrpr_webrecr...

Powered by MHR

jobs.exeter.ac.uk

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Reposted by Alice Maestri

Jamie Hall @jpjhall.bsky.social · Jul 23

🆕 I’m looking for a postdoc to join the group!
This is for a project as part of the @multidefence.bsky.social consortium, looking at genome defences and horizontal gene transfer in Pseudomonas. Deadline 12th August. 🧵
my.corehr.com/pls/ulivrecr...

'

my.corehr.com

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