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Reposted by Lingchen He 何灵尘

Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 8d

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson

www.gla.ac.uk

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 12d

🔥🔥🔥

Zamin Iqbal @zaminiqbal.bsky.social · 12d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 13d

Congrats!!

yilanfan.bsky.social @yilanfan.bsky.social · 13d

It’s been a long but beautiful journey. Grateful for the support from all co-authors and colleagues, especially @filizkuybu.bsky.social 🙌, with whom I shared many long days and restless nights. Many more questions lie ahead!

Hopfner Lab @hopfnerlab.bsky.social · 19d

Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

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Reposted by Lingchen He 何灵尘

Sorek Lab @soreklab.bsky.social · 27d

Phage "satellites" that produce capsids but have no genes to produce tails have puzzled scientists for a long time. These are abundant as prophages in bacteria, but it was unclear how they can infect without tails

Now, Penadés & co show that they hijack tails from other phages. Incredible!

José R Penadés @jrpenades.bsky.social · 28d

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

www.cell.com

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

Thank you Joao!

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

😃

www.cell.com/cell-host-mi...

(Ph)ighting Phages: How Bacteria Resist Their Parasites

Bacteria are threatened by viral attack in every environment they colonize. For more than 100 years, microbiologists have investigated the mechanisms in place to contain these attacks. Rostøl and Marr...

www.cell.com

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

😉Thank you Aisling!

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

😊Thank you Nuria!

Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

A big thank you for everyone involved Jinlong,
@alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

www.cell.com

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

Finally, we demonstrated evolutionary homology between cf-PICI and phage HK97 capsids, while showing that cf-PICIs avoid interference during capsid assembly through finely tuned interactions, thereby ensuring efficient and specific packaging of their own DNA. @jonaszpatkowski.bsky.social

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

In addition, we identified adaptor and connector genes as central to capsid–tail chimeric assembly, with high variability during the evolution of tail-less capsids.

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

This uncovers unexpected complexity in phage–satellite interactions, challenging the long-held view that satellites rely on a single helper phage to complete their lifecycle.

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

We revealed a key feature of tail piracy: cf-PICIs can exploit multiple helper phages—one inducing their cycle, another supplying tails. Remarkably, cf-PICIs can even accumulate tail-less particles without helper phage induction, and factors causing cell lysis can release them.

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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28d

We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social

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Reposted by Lingchen He 何灵尘

PHD Comics @phdcomics.com · Aug 10

Did you get the email I sent 😭

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Reposted by Lingchen He 何灵尘

cc 🌷 @ccsartcafe.bsky.social · Aug 1

Picking blueberries 💙🐦

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Reposted by Lingchen He 何灵尘

Emmanuele Severi @emmseveri.bsky.social · Jul 29

#phagesky

www.cell.com/cell-host-mi...

The prototypic crAssphage is a linear phage-plasmid

Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid with a broad ho...

www.cell.com

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Lingchen He 何灵尘 @lingchenhe.bsky.social · Jul 28

Congratulations Franklin, Yi and all the authors!! Very beautiful work!

Franklin Nobrega @fnobrega.bsky.social · Jul 28

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites

Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

www.cell.com

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Reposted by Lingchen He 何灵尘

Franklin Nobrega @fnobrega.bsky.social · Jun 19

Thank you to everyone who attended the 3rd UK MGE workshop. What an incredible few days of science and community building! Next stop: York 2026, hosted by @pcmfogg.bsky.social. See you all next year! #UKMGE

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Reposted by Lingchen He 何灵尘

Tung Le @tunglejic.bsky.social · May 9

1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below.
shorturl.at/o6S1w

A bacterial CARD-NLR immune system controls the release of gene transfer agents

Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...

shorturl.at

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Reposted by Lingchen He 何灵尘

Fernando Gonzalez-Candelas @fgonzalef.bsky.social · May 7

Good papers, like good wine, need maturing. I'm proud and thrilled to share our work on genomic epidemiology of K.pneumoniae in Valencia and differential transmission patterns of resistances, part of Neris Garcia's PhD thesis and the NLSAR consortium. go.uv.es/td8iL4c #publichealth #EpiSky 🧬🖥️

Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020 - ...

Background The emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics wi...

go.uv.es

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Reposted by Lingchen He 何灵尘

Jose A Escudero @jaescudero.bsky.social · May 8

🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉

Short 🧵
www.science.org/doi/10.1126/...

Mobile integrons encode phage defense systems

Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

www.science.org

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Lingchen He 何灵尘 @lingchenhe.bsky.social · May 8

Three to one, tales! (✓)

RM @rsbmilne.bsky.social · May 8

Virtual Virology is back - our first ever phage session. Do join us...

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Reposted by Lingchen He 何灵尘

Andreas Haag @andreashaag.bsky.social · May 1

Interested in fighting AMR? Come and join us at St Andrews. applications are open until 15th May to students worldwide!

Andreas Haag @andreashaag.bsky.social · Mar 31

🚨 PhD opportunity in my lab with @mfwhite2.bsky.social!
Use bacterial viruses (phages) to take on antibiotic-resistant superbugs 🦠🧫
Join us at St Andrews to explore virus–bacteria battles.
🔬 Apply now: www.findaphd.com/phds/project...
#PhD #Microbiology #PhageTherapy #AntibioticResistance

Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews on FindAPhD.com

PhD Project - Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews, listed on FindAPhD.com

www.findaphd.com

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Trevor Lithgow @trevor-lithgow.bsky.social · May 1

"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors”

www.science.org/doi/10.1126/...

Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons

Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.

www.science.org

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