Lightnews — Scholar-powered news

Reposted by Alister Burt

Alejandro Llorente, Ph.D. @llorentealejandro.bsky.social · 6h

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...

www.biorxiv.org

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Alister Burt @alisterburt.bsky.social · 5h

Egg, meet chicken

Alister Burt @alisterburt.bsky.social · 6h

so satisfying - question: are all the best microscopists Dutch?

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Reposted by Alister Burt

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 7h

Incredible video. I suspect I will end up watching every video on the channel.

Exploring White Light Interferometry! (WLI / CSI)

YouTube video by Huygens Optics

www.youtube.com

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Alister Burt @alisterburt.bsky.social · 7h

It’s terrifying to watch the UK be so easily pushed into spending more on drugs…

youtu.be/_xdYrg3G_00?...

UK Set To Cave To Trump On NHS Drug Prices | #NovaraLIVE

YouTube video by Novara Media

youtu.be

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Alister Burt @alisterburt.bsky.social · 8h

This has been a real pain point for Warp users since we moved to Linux, psyched to see it solved

Awesome work @hamid13r.bsky.social ! Thank you for taking the time to share your solution more widely :-)

hamid13r.bsky.social @hamid13r.bsky.social · 2d

Working on #WarpTools I have the old problem of removing "bad tilts". These are views that I skipped in #etomo to get a better model...

I wrote a python code to turn the UseTilt to False in the XML files for those views and improve the tomo reconstruction.
#teamtomo
github.com/hamid13r/war...

warp_lamella_adapters/remove_bad_views.py at main · hamid13r/warp_lamella_adapters

A short optimized pipeline to get lamella tomography (with pretilt and with some tilts obscured or mistracked) to work well with Warp - hamid13r/warp_lamella_adapters

github.com

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Alister Burt @alisterburt.bsky.social · 1d

🙈🙈🙈

Alister Burt @alisterburt.bsky.social · 1d

finally hit πthon

Savannah Ostrowski @savannah.dev · 1d

The stable release of Python 3.14 is out now! Go, go, go update! 🙌

discuss.python.org/t/python-3-1...

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Reposted by Alister Burt

Jakob Meier-Credo @meiercredo.bsky.social · 19d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Reposted by Alister Burt

Jan-Hannes Schaefer @jhschaef.bsky.social · 4d

Helical Reconstruction of Amyloids in cryoSPARC?
We present guidelines, limitations & future perspectives for processing amyloids in cryoSPARC @structurabio.bsky.social.
Great collaboration of the Kelly Lab and @landerlab.bsky.social #cryoEM #amyloid www.biorxiv.org/content/10.1...

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Reposted by Alister Burt

Katie Mack @astrokatie.com · 5d

I think for me the most compelling answer for "why fund basic research?" (and the one most relevant to the people doing the work) is that humans are curious and finding stuff out makes us happy and fulfilled. Science is a thing humans like. Life would be more dull and sad if we didn't do it.

end/🧵

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Alister Burt @alisterburt.bsky.social · 6d

😍

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Alister Burt @alisterburt.bsky.social · 7d

I don’t think they are exactly the same, just sometimes :-) simply saying that many people I admire have personalities people find grating/perceive as arrogant

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Alister Burt @alisterburt.bsky.social · 7d

you see lack of professionalism I see desire for authenticity and intellectual honesty

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Alister Burt @alisterburt.bsky.social · 7d

Sad news. Systemic change like this is needed, this a step backwards on the path to a slightly better world

Joe Greener @jgreener64.bsky.social · 7d

A shame that GigaScience's Hong Kong team have been laid off by the owners, BGI. GigaScience has been influential in its push for open data.

www.open-bio.org/2025/09/30/2...

GigaScience: 15 years of great open science publishing & the end of an era?

To begin something is difficult; to keep something going is a different challenge. Even when it is the right thing to do, if it does not yield economic benefit in the short term, it may be difficult t...

www.open-bio.org

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Alister Burt @alisterburt.bsky.social · 8d

“If you have a productivity problem, you’re either not annoyed enough, you’re annoyed by something you can’t actually control, or you’re annoyed in the bad way, the kind that makes you want to skip town rather than dig in.” this resonated most for me

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Alister Burt @alisterburt.bsky.social · 8d

got this email this morning, gold!

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Reposted by Alister Burt

Joe Greener @jgreener64.bsky.social · 8d

Another great blog post by @mastroianni.bsky.social, this time explaining why being a scientist can sometimes feel so... annoying?

www.experimental-history.com/p/thank-you-...

Thank you for being annoying

OR: whack 'em if you got 'em

www.experimental-history.com

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Reposted by Alister Burt

Siân Culley @superresolusian.bsky.social · 9d

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Bioimage Analysis Specialist | King's College London

www.kcl.ac.uk

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Alister Burt @alisterburt.bsky.social · 9d

Guy buys old industrial robots and builds his own controller

youtu.be/IBtIB9mVzEI?...

I Bought a $40k Robot for $200, Then Let Random People Control It

YouTube video by Excessive Overkill

youtu.be

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Alister Burt @alisterburt.bsky.social · 9d

Hah! I guess the existing system is also far from perfect

Reposted by Alister Burt

Gary Stevenson @garyseconomics.bsky.social · 11d

How wealth inequality is destroying democracies worldwide w/ Chloe Swarbrick MP

youtu.be/zl_LgDjpzxE

The first politician on Gary's Economics

YouTube video by Garys Economics

youtu.be

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Alister Burt @alisterburt.bsky.social · 10d

(currently in the pipeline)

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Alister Burt @alisterburt.bsky.social · 10d

Looks like I might not be able to stay in the US even if I want to…

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Alister Burt @alisterburt.bsky.social · 11d

cool computer graphics work from @cemyuksel.com and co seems to solve objects going through each other in simulations!

Great explainer/demos from Two Minute Papers, video title is kinda annoying when 5/6 authors are not from Nvidia

graphics.cs.utah.edu/research/pro...

youtu.be/7NF3CdXkm68?...

NVIDIA Just Solved The Hardest Problem in Physics Simulation!

YouTube video by Two Minute Papers

youtu.be

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