TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
Reality is far more exciting and interesting what any computer program can come up with, so it’s sad when people make these grand statements that LLMs are replacing scientists/experimental work.
February 5, 2026 at 10:01 AM
Reality is far more exciting and interesting what any computer program can come up with, so it’s sad when people make these grand statements that LLMs are replacing scientists/experimental work.
Reposted by TJ McCorvie
As cryoEM becomes automated people forget
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
January 31, 2026 at 3:01 AM
As cryoEM becomes automated people forget
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Reposted by TJ McCorvie
A rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
January 30, 2026 at 2:04 PM
A rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.